Skip to main content

Advertisement

Log in

Progress of research on Inonotus obliquus

  • Review
  • Published:
Chinese Journal of Integrative Medicine Aims and scope Submit manuscript

Abstract

Inonotus obliquus has high nutritional and medicinal value, especially in treating malignant tumors, diabetes, cardiovascular disease and AIDS, attracting significant attention from scholars in recent years. In this paper, the biological characteristics, chemical composition and pharmacologic effects of Inonotus obliquus were summarized. And the applications in medicine and food were introduced. Future research on Inonotus obliquus was also discussed in order to make Inonotus obliquus obtain effective exploitation and satisfy people’s demands.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Wasser SP. Medicinal mushrooms as a source of antitumor and imunmodulating polysaccharides. Appl Microbiol Biotechnol 2002;60:258–274.

    Article  PubMed  CAS  Google Scholar 

  2. He J, Feng XZ. Studies on chemical constituents of Fuscoporia obliqua. Chin Tradit Herbal Drugs (Chin) 2001;32:4–6.

    Google Scholar 

  3. Huang NL. Inonotus obliquus—medicinal fungus in folk of Russia. Edible Fungi China (Chin) 2002;21:7–8.

    CAS  Google Scholar 

  4. He J, Feng XZ, Lu Y, Zhao B. Three new triterpenoids from Fuscoporia oblique. J Asian Nat Prod Res 2001;3:55–61.

    Article  CAS  Google Scholar 

  5. Shin Y, Tamai Y, Terazawa M. Chemical constituents of Inonotus obliquus IV. Triterpene and steroids from cultured mycelia. Eurasion J Forest Res 2001;2:27–30.

    Google Scholar 

  6. Shin Y, Tamai Y, Terazawa M. Chemical constituents of Inonotus obliquus II: a new triterpene,21,24-cyclopentalanosta-3β, 21, 25-triol-8-ene from sclerotium. J Wood Sci 2001;47:313–316.

    Article  CAS  Google Scholar 

  7. Shin Y, Tamai Y, Terazawa M. Chemical constituents of Inonotus obliquus I: a new triterpene, 3β-hydroxy-8, 24-dien-lanosta-21, 23-lactone from sclerotium. Eurasian J Forest Res 2000;1:43–50.

    CAS  Google Scholar 

  8. Shin Y, Tamai Y, Terazawa M. Chemical constituents of Inonotus obliquus III: A new triterpene,3β,22, 25-trihydroxylanosta-8-ene from screrotia. Medi Mushroom 2001;2:201–207.

    Google Scholar 

  9. Shin Y, Tamai Y, Terazawa M. Triterpenoids, steroids and a new sesquiterpen from Inonotus obliquus. Intl J Med Mushrooms 2002;4:77–84.

    Google Scholar 

  10. Sayaka T, Takeshi Y, Yasuko I, Shun-icji W, Yoshihide U, Kazuo S, et al. Three new lanostane triterpenoids from Inonotus obliquus. Helvetica Chimica Acta 2007;90:2047–2057.

    Article  Google Scholar 

  11. Kahlos K, Hiltunen R, Schantz M. 3β-hydroxy-lanosta-8, 24-dien-21-al, a new triterpene from Inonotus obliquus. Planta Med1 1984;50:197–198.

    Article  CAS  Google Scholar 

  12. Kahlos K, Hiltunen R. 3β,22-dihydroxylanosta-7,9(11), 24-triene: a new, minor compound from Inonotus obliquus. Planta Med1 1986;52:495–496.

    Article  CAS  Google Scholar 

  13. Nakata T, Yamada T, Taji S, Ohishi H, Wada S, Takuda H, et al. Stucture determination of inonotsuoxides A and B and in vivo anti-tumor promoting activity of inotodiol from the sclerotia of Inonotus obliquus. Bioorg Med Chem 2007;15:257–264.

    Article  PubMed  CAS  Google Scholar 

  14. Taji S, Yamada T, Wada S, Tokuda H, Sakuma K, Tanaka R. Lanostane-type triterpenoids from the sclerotia of Inonotus obliquus possessing anti-tumor promoting activity. Eur J Med Chem 2008;43:2373–2379.

    Article  PubMed  CAS  Google Scholar 

  15. Ham SS, Kim SH, Moon SY, Chung MJ, Cui CB, Han EK, et al. Antimutagenic effects of subfractions of Chaga mushroom (Inonotus obliquus) extract. Mutat Res 2009;672:55–59.

    PubMed  CAS  Google Scholar 

  16. Ichimura T, Watanabe O, Maruyama S. Inhibition of HIV-1 protease by water-soluble lignin-like substance from an edible mushroom, Fuscoporia obliqua. Biosci Biotechnol Biochem 1998;62:575–577.

    Article  PubMed  CAS  Google Scholar 

  17. Babitskaia VG, Shcherba VV, Ikonnikova NV. Melanin complex of the fungus Inonotus obliquus. Prikladnaya Biokhimiya Mikrobiologiya 2000;36:439–444.

    CAS  Google Scholar 

  18. Kukulianskaia TA, Kurchenko NV, Kurchenko VP, Babitskaia VG. Physicochemical properties of melanins produced by Inonotus obliquus (“chagi”) in the nature and the cultivated fungus. Prikl Biokhim Mikrobiol 2002;38:68–72.

    PubMed  CAS  Google Scholar 

  19. Babitskaia VG, Shcherba VV. The nature of melanin pigments from some micro- and macromycetes. Prikl Biokhim Mikrobiol 2002;38:286–291.

    PubMed  CAS  Google Scholar 

  20. Kim YO, Han SB, Lee HW, Ahn HJ, Yoon YD, Jung JK, et al. Immuno-stimulating effect of the endo-polysaccharide produced by submerged culture of Inonotus obliquus. Life Sci 2005;77:2438–2456.

    Article  PubMed  CAS  Google Scholar 

  21. Gorzkowski T. Effect of decoction of Poria obliqua on growth of transplanted Crocker’s sarcoma in mice. Patol Pol 1955;6:293–299.

    PubMed  CAS  Google Scholar 

  22. Youn MJ, Kim JK, Park SY, Park C, Kim ES, Park KI, et al. Potential anticancer properties of the water extract of Inonotus obliquus by induction of apoptosis in melanoma B16-F10 cells. J Ethnopharmacol 2009;121:221–228.

    Article  PubMed  Google Scholar 

  23. Zhang HL, Yang S, Song YN, Jiang W, Jia F, Zhu JF, et al. Comparison of immune function of different extractions of Fuscoporia oblique on mice. J Microbiol (Chin) 2007;27:20–23.

    Google Scholar 

  24. Kim YO, Park HW, Kim JH, Lee JY, Moon SH, Shin CS. Anti-cancer effect and structural characterization of endo-polysaccharide from cultivated mycelia of Inonotus obliquus. Life Sci 2006;79:72–80.

    Article  PubMed  CAS  Google Scholar 

  25. Wang LB, Sun DZ, Zhong XH, Jin RJ, Chen HY. Observation on anti-proliferation and apoptosis inducement of cells of lung cancer from Inonotus obliquus. Edible Fungi China (Chin) 2007;26:40–43.

    CAS  Google Scholar 

  26. Burczyk J, Gawron A, Slotwinska M, Smietana B, Terminska K. Antimitotic activity of aqueous extracts of Inonotus obliquus. Boll Chim Farm 1996;135:306–309.

    PubMed  CAS  Google Scholar 

  27. Rzymowska J. The effect of aqueous extracts from Inonotus obliquus on the mitotic index and enzyme activities. Boll Chim Farm 1998;137:13–15.

    PubMed  CAS  Google Scholar 

  28. Kahlos K, Kangas L, Hiltunen R. Antitumor activity of some compounds and fractions from an n-hexane extract of Inonotus obliquus. Acta Pharm Fenn 1987;96:33–40.

    CAS  Google Scholar 

  29. Zhao FQ, Piao HS, Han CJ. Studies on anti-mutation active constituents of the Fuscoporia oblique. J Med Sci Yanbian Univ (Chin) 2004;27:250–251.

    CAS  Google Scholar 

  30. Chen YQ, Zhou LJ, Li Y. Study on experimental comparison of hypoglycemic effect of polysaccharides of cultured mycelia, sclerotia and wild sclerotia from Inonotus obliquus. Edible Fungi (Chin) 2006;28:52–54.

    CAS  Google Scholar 

  31. Mizuno T, Zhuang C, Abe K, Okamoto H, Kiho T, Uai S, et al. Antitumor and hypo-glycemic activities of polysaccharides from the scleritia and mycelia of Inonotus obliquus. Int J Med Mushrooms 1999;1:301–316.

    CAS  Google Scholar 

  32. Zjawiony JK. Biologically active compounds from Aphyllophophorales (polypore) Fungi. J Nat Prod 2004;67:300–310.

    Article  PubMed  CAS  Google Scholar 

  33. Kahlos K, Lesnau A, Lange W, Lindequist U. Preliminary tests of antiviral activity of two Inonotus obliquus strains. Fitoterapia 1996;67:345–347.

    Google Scholar 

  34. Zhang ZS, Yang CH, Shi S, Zhao JJ. The effects of Inonotus obliquus on immunity ability of mice. Food Res Develop (Chin) 2008;29:35–37.

    Google Scholar 

  35. Hyun KW, Jeong SC, Lee DH, Park JS, Lee JS. Isolation and characterization of a novel platelet aggregation inhibitory peptide from the medicinal mushroom, Inonotus obliquus. Peptides 2006;27:1173–1178.

    Article  PubMed  CAS  Google Scholar 

  36. Park YM, Won JH, Kim YH, Choi JW, Park HJ, Lee KT. In vivo and in vitro anti-inflammatory and anti-nociceptive effects of the methanol extract of Inonotus obliquus. J Ethnopharmacol 2005;101:120–128.

    Article  PubMed  Google Scholar 

  37. Gao YJ, Gao XL, Wu GH, Song L. Study on stability of antioxidance extraction from Inonotus obliquus. Food Res Develop (Chin) 2007;28:77–79.

    Google Scholar 

  38. Cui Y, Kim DS, Park KC. Antioxidant effect of Inonotus obliquus. J Ethnopharmacol 2005;96:79–85.

    Article  PubMed  Google Scholar 

  39. Nakajima Y, Sato Y, Konishi T. Antioxidant small phenolic ingredients in Inonotus obliquus (persoon) Pilat (Chaga). Chem Pharm Bull (Tokyo) 2007;55:1222–1226.

    Article  CAS  Google Scholar 

  40. Rasina LN. Effect of cryosubstance Chagi on deposition or isolation of 90Sr and on the effect of prolonged external exposure to gamma-radiation. Radiats Biol Radioecol 2002;42:399–403.

    PubMed  CAS  Google Scholar 

  41. Park YK, Lee HB, Jeon EJ. Chaga mushroom extract inhibits oxidative DNA damage in human lymphocytes as assessed by comet assay. Biofactors 2004;21:109–112.

    Article  PubMed  CAS  Google Scholar 

  42. Li WZ, Hu Fl, Wan XS, Geng DG, Gui L, Yang C. Radical scavenging activities of extracts from fermentation broth of Inonotus obliquus and the fermentation condition optimization. J Biology (Chin) 2006;23:22–24.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Xiu-hong Zhong  (钟秀宏).

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zhong, Xh., Ren, K., Lu, Sj. et al. Progress of research on Inonotus obliquus . Chin. J. Integr. Med. 15, 156–160 (2009). https://doi.org/10.1007/s11655-009-0156-2

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11655-009-0156-2

Key Words

Navigation