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Surgical Resection of 78 Pancreatic Solid Pseudopapillary Tumors: a 30-Year Single Institutional Experience

  • Original Article
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Journal of Gastrointestinal Surgery

Abstract

Background

Solid pseudopapillary tumors (SPTs) are rare, benign tumors of the pancreas that present as heterogeneous masses. We sought to evaluate the short- and long-term outcomes of surgical resected SPTs. Patients managed via initial surveillance were compared to those who underwent upfront resection.

Methods

A prospectively maintained institutional database was used to identify patients who underwent surgical resection for a SPT between 1988 and 2018. Data on clinicopathological features and outcomes were collected and analyzed.

Results

Seventy-eight patients underwent surgical resection for SPT during the study period. The mean age was 34.0 ± 14.6 years and a majority were female (N = 67, 85.9%) and white (N = 46, 58.9%). Thirty patients (37.9%) were diagnosed incidentally. Imaging-based presumed diagnosis was SPT in 49 patients (62.8%). A majority were located in the body or tail of the pancreas (N = 47, 60.3%), and 48 patients (61.5%) underwent a distal pancreatectomy. The median tumor size was 4.0 cm (IQR, 3.0–6.0), nodal disease was present in three patients (3.9%), and R0 resection was performed in all patients. No difference was observed in clinicopathological features and outcomes between patients who were initially managed via surveillance and those who underwent upfront resection. None of the patients under surveillance had nodal disease or metastasis at the time of resection; however, one of them developed recurrence of disease 95.1 months after resection. At a median follow-up of 36.1 months (IQR, 8.1–62.1), 77 (%) patients were alive and one patient (1.3%) had a recurrence of disease at 95.1 months after resection and subsequently died due to disease.

Conclusions

SPTs are rare pancreatic tumors that are diagnosed most frequently in young females. While a majority are benign and have an indolent course, malignant behavior has been observed. Surgical resection can result in exceptional outcomes.

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Author notes

  1. Michael J. Wright and Ammar A. Javed contributed equally to this work.

Authors and Affiliations

  1. The John L. Cameron Division of Hepatobiliary and Pancreatic Surgery, The Johns Hopkins Hospital, Baltimore, MD, USA

    Michael J. Wright, Ammar A. Javed, Tyler Saunders, Yayun Zhu, Richard A. Burkhart, Jun Yu, Jin He, John L. Cameron, Martin A. Makary, Christopher L. Wolfgang & Matthew J. Weiss

  2. Pancreas Cancer Multidisciplinary Clinic, Liver Cancer Multidisciplinary Clinic, Surgical Oncology Fellowship, Miller Coulson Academy of Clinical Excellence, Johns Hopkins University, 600 N. Wolfe St. / Blalock 685, Baltimore, MD, 21287, USA

    Matthew J. Weiss

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  1. Michael J. Wright
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Contributions

All the authors contributed to the conception of the study. AAJ, MJWr, TS, and YZ preformed data collection and composed the first draft of the manuscript. RAB, JU, JH, JLC, MAM, CLW, and MJWe critically reviewed and edited the final draft of the manuscript. All the authors take responsibility for the accuracy of the repotted data.

Corresponding author

Correspondence to Matthew J. Weiss.

Ethics declarations

The study was approved by the Institutional Review Board for Human Research and complied with all Health Insurance Portability and Accountability Act regulations.

Conflict of Interest

The authors declare that they have no conflict of interest.

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Wright, M.J., Javed, A.A., Saunders, T. et al. Surgical Resection of 78 Pancreatic Solid Pseudopapillary Tumors: a 30-Year Single Institutional Experience. J Gastrointest Surg 24, 874–881 (2020). https://doi.org/10.1007/s11605-019-04252-7

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