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Solid Pseudopapillary Neoplasms of the Pancreas: a 19-Year Multicenter Experience in China

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Journal of Gastrointestinal Surgery Aims and scope

Abstract

Aim

The aim of this study was to determine the clinicopathological features, surgical management, and prognosis of solid pseudopapillary neoplasms (SPNs) of the pancreas.

Methods

This study conducted a retrospective analysis of 97 patients who underwent surgery for a pathologically confirmed SPN in five hospitals between January 1996 and December 2014.

Results

The 97 cases included 93 female and 4 male patients, and the average age was 31.2 years. The tumor was located in the body or tail (70.1 %), the head (20.6 %), and the neck (9.3 %). All patients underwent surgical exploration, including distal pancreatectomy (63.9 %), pancreaticoduodenectomy (20.6 %) (partial portal vein or superior mesenteric vein resection and artificial vascular graft reconstruction performed in 4.1 % of the patients), central pancreatectomy (10.3 %), enucleation (5.2 %), and liver resection (1.0 %). 16.5 % of the patients had malignant tumors. The positive rate of Ki-67 was 66.7 % in patients diagnosed with a malignant neoplasm and was comparable to 8.4 % of the patients diagnosed to have a benign neoplasm (p < 0.001). After a median follow-up of 70.1 months, three patients had recurrence and one patient died of liver metastasis.

Conclusions

SPN is a rare neoplasm with low malignant potential. Surgical resection is warranted even in the presence of local invasion or metastases as patients demonstrate excellent long-term survival. Positive immunoreactivity for Ki-67 may predict the malignant potential and poor outcome of SPNs.

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Acknowledgments

We express our appreciation to Dr. Thomas Aloia (Surgical Oncology, MD Anderson) who has offered many valuable comments and suggestions. This study is supported by the Department of Health of Zhejiang Province (2013KYB043).

Conflict of Interest

No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article.

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Authors and Affiliations

  1. Department of Abdominal Surgery, Zhejiang Cancer Hospital, 38# Guangji Road, Hangzhou, 310022, China

    Pengfei Yu, Yian Du, Litao Yang & Wenjuan Yin

  2. Zhejiang Province Hospital of Traditional Chinese Medicine, Hangzhou, China

    Xiangdong Cheng & Zhiyuan Xu

  3. The Second Affiliated Hospital of Jiaxing Medical College, Jiaxing, China

    Zhengxiang Zhong & Xiaoguang Wang

  4. Huzhou Center Hospital, Huzhou, China

    Hongbao Xu

  5. Jinhua Guangfu Hospital, Jinhua, China

    Conggang Hu

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  1. Pengfei Yu
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Correspondence to Pengfei Yu.

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Yu, P., Cheng, X., Du, Y. et al. Solid Pseudopapillary Neoplasms of the Pancreas: a 19-Year Multicenter Experience in China. J Gastrointest Surg 19, 1433–1440 (2015). https://doi.org/10.1007/s11605-015-2862-8

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  • DOI: https://doi.org/10.1007/s11605-015-2862-8

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