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Phase II Study of Single Intraperitoneal Chemotherapy Followed by Systemic Chemotherapy for Gastric Cancer with Peritoneal Metastasis

  • Original Article
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Journal of Gastrointestinal Surgery Aims and scope

Abstract

Background

We conducted a phase II study involving a single administration of intraperitoneal chemotherapy with paclitaxel followed by sequential systemic chemotherapy with S-1+ paclitaxel for advanced gastric cancer patients with peritoneal metastasis.

Methods

Gastric cancer patients with peritoneal metastasis were enrolled. Paclitaxel (80 mg/m2) was administered intraperitoneally at staging laparoscopy. Within 7 days, patients received systemic chemotherapy with S-1 (80 mg/m2/day on days 1–14) plus paclitaxel (50 mg/m2 on days 1 and 8), followed by 7-days rest. The responders to this chemotherapy underwent second-look laparoscopy, and gastrectomy with D2 lymph node dissection was performed in patients when the disappearance of peritoneal metastasis had been confirmed. The primary endpoint of the study was overall survival rate.

Results

Thirty-five patients were enrolled. All patients were confirmed as having localized peritoneal metastasis by staging laparoscopy. Eventually, gastrectomy was performed in 22 patients. The median survival time of the total patient population and those patients in which gastrectomy was performed was 21.3 and 29.8 months, respectively. The overall response rate was 65.7 % for all patients. The frequent grade 3/4 toxic effects included neutropenia and leukopenia.

Conclusions

Sequential intraperitoneal and intravenous paclitaxel plus S-1 was well tolerated in gastric cancer patients with peritoneal metastasis.

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Acknowledgments

The authors would like to express their appreciation to Dr. Harumasa Ohyanagi, Vice Board Director of the University of KinDAI Himeji, for his expert comments on the manuscript. We also wish to thank Ms. Fusako Kamada for her technical assistance.

Funding

The study was not supported by any grant.

Author information

Authors and Affiliations

  1. Surgery, Kinki University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka, 589-8511, Japan

    Motohiro Imano, Atsushi Yasuda, Ying-Feng Peng, Hiroaki Kato, Masayuki Shinkai, Takushi Yasuda, Haruhiko Imamoto, Yoshifumi Takeyama, Kiyokata Okuno, Hiroshi Furukawa & Hitoshi Shiozaki

  2. Cancer Center, Kinki University Hospital, 377-2 Ohno-higashi, Osaka-Sayama, Osaka, 589-8511, Japan

    Motohiro Imano & Yoshifumi Takeyama

  3. Pathology, Kinki University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka, 589-8511, Japan

    Tatsuki Itoh & Takao Satou

  4. Division of Pharmacotherapy, Kinki University Faculty of Pharmacy, 3-4-1 Kowakae, Higashi-Osaka, Osaka, 577-5802, Japan

    Masahiro Tsubaki & Shozo Nishida

  5. Division of Biostatistics, Clinical Research Center, Kinki University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka, 589-8511, Japan

    Yasutaka Chiba

Authors
  1. Motohiro Imano
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  2. Atsushi Yasuda
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  3. Tatsuki Itoh
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  4. Takao Satou
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  5. Ying-Feng Peng
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  6. Hiroaki Kato
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  7. Masayuki Shinkai
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  8. Masahiro Tsubaki
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  9. Yasutaka Chiba
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  10. Takushi Yasuda
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  11. Haruhiko Imamoto
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  12. Shozo Nishida
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  13. Yoshifumi Takeyama
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  14. Kiyokata Okuno
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  15. Hiroshi Furukawa
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  16. Hitoshi Shiozaki
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Corresponding author

Correspondence to Motohiro Imano.

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Imano, M., Yasuda, A., Itoh, T. et al. Phase II Study of Single Intraperitoneal Chemotherapy Followed by Systemic Chemotherapy for Gastric Cancer with Peritoneal Metastasis. J Gastrointest Surg 16, 2190–2196 (2012). https://doi.org/10.1007/s11605-012-2059-3

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  • DOI: https://doi.org/10.1007/s11605-012-2059-3

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