Abstract
Background
Appendectomy is one of the most common emergency operations performed in the pediatric population. The aim of this pooled analysis is to compare the outcome from complicated appendicitis (CA) and uncomplicated appendicitis (UA) following laparoscopic appendectomy (LA) and open appendectomy (OA) in children.
Methods
A systematic literature search was performed. Primary outcome measures were incidence of complications, intra-abdominal abscess, and wound infection. Secondary outcomes were length of operation, length of hospital stay, incidence of bowel obstruction, and readmission.
Results
Seventy-three thousand one hundred fifty appendectomies for UA and 34,474 appendectomies for CA were included. For UA, the only significant difference between the groups was a reduced length of hospital stay following LA. LA in CA was associated with reduced complications (pooled odds ratio [POR] = 0.53; P < 0.05), wound infections (POR = 0.42; P < 0.05), length of hospital stay (WMD = −0.67; P < 0.05), and bowel obstruction episodes (POR = 0.8; P < 0.05), but an increased incidence of intra-abdominal abscess and length of operation.
Conclusion
Pooled analysis demonstrates that, in children with uncomplicated acute appendicitis, LA is associated with a reduced hospital stay but broad equivalence in postoperative morbidity when compared with the conventional approach. Although overall morbidity is reduced when the laparoscopic approach is utilized, in cases of CA, the risk of intra-abdominal abscess is increased.
Similar content being viewed by others
References
Browse’s introduction to the symptoms and signs of surgical disease. 4 ed. Hodder Arnolc 2006.
Addiss DG, Shaffer N, Fowler S, Tauxe RV. The epidemiology of appendicitis and appendectomy in the United States. Am J Epidemiol 1990; 132: 910 –25
McBurney C. The incision made in the abdominal wall in the cases of appendicitis, with a description of a new method of operating. Ann Surg 1894; 20: 38 – 43
Semm K. Endoscopic appendectomy. Endoscopy 1983; 15: 59-64
Sauerland S, Leferine R, Neugebauer ER. Laparoscopic versus open surgery for suspected appendicitis. Cochrane Database Syst Rev 2004; 18: CD001546
Bennett J, Boddy A, Rhodes M. Choice of approach for appendicectomy: a meta-analysis of open versus laparoscopic appendicectomy. Surg Laparosc Endosc Percutan Tech 2007; 17: 245 – 55.
Ortega AE, Hunter JG, Peters JH, Swanstrom LL, Schirmer B. A prospective, randomized comparison of laparoscopic appendectomy with open appendectomy. Laparoscopic Appendectomy Study Group. Am J Surg 1995; 169: 208 – 12
Tang E, Ortega AE, Anthone GJ, Beart RW Jr. Intraabdominal abscesses following laparoscopic and open appendectomies. Surg Endosc 1996; 10: 327 – 8
Horwitz JR, Custer MD, May BH, Mehall JR, Lally KP. Should laparoscopic appendectomy be avoided for complicated appendicitis in children? J Pediatr Surg 1997; 32 (11): 1601 – 3
Faiz O, Blackburn SC, Clark J, Bottle A, Curry JI, Farrands P, Aylin P. Laparoscopic and conventional appendicectomy in children: outcomes in English hospitals between 1996 and 2006. Pediatr Surg Int 2008; 24: 1223 – 7
Aziz O, Athanasiou T, Tekkis PP, Purkayastha S, Haddow J, Malinovski V, Paraskeva P, Darzi A. Laparoscopic versus open appendectomy in children: a meta-analysis. Ann Surg 2006; 243: 17 – 27
Pokala N, Sadhasivam S, Kiran RP, Parithivel V. Complicated appendicitis—is the laparoscopic approach appropriate? A comparative study with the open approach: outcome in a community hospital setting. Am Surg 2007; 73: 737 – 41
Oxford Centre for Evidence-Based Medicine—Levels of evidence, March 2009
DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin trials 1986; 7: 177 – 88
Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med 2002; 21: 1539 – 58
Canty TG, Collins D, Losasso B, Lynch F, Brown C. Laparoscopic Appendectomy for Simple and Perforated appendicitis in Children: The Procedure of Choice? J Pediatr Surg 2000; 35: 1582 – 5
Esposito C, Borzi P, Valla JS, Mekki M, Nouri A, Becmeur F, Allal H, Settimi A, Shier F, Sabin MAG, Mastrianni L. Laparoscopic versus Open Appendectomy in Children: A retrospective comparative study of 2,332 cases. World J Surg 2007; 31: 750 – 5
Ikeda H, Ishimaru Y, Takayasu H, Okamura K, Kisaki Y, Fujino J. Laparoscopic versus Open Appendectomy in Children with Uncomplicated and Complicated Appendicitis. J Pediatr Surg 2004; 39: 1680 – 5
Jen HC, Shew SB, Laparoscopic versus open appendectomy in children: outcomes comparison based on a statewide analysis. J Surg Res 2010; 161: 13 – 7
Lavonius MI, Liesjarvi S, Ovaska J, Pajulo O, Ristkari S, Alanen M. Laparoscopic versus open appendectomy in children: a prospective randomised study. Eur J Pediatr Surg 2001; 11: 235 – 8
Lee SL, Yaghoubian A, Kaji A. Laparoscopic vs Open Appendectomy in Children: Outcomes Comparison based on Age, Sex, and Perforation Status. Arch Surg 2011; 146: 1118 – 21
Li P, Xu Q, Ji Z, Gao Y, Zhang X, Duan Y, Guo Z, Zheng B, Guo X, Wu X. Comparison of surgical stress between laparoscopic and open appendectomy in children. J Pediatr Surg 2005; 40: 1279 – 83
McKinlay R, Neeleman S, Klein R, Stevens K, Greenfeld J, Ghory M, Consentino C. Intraabdominal abscess following open and laparoscopic appendectomy in the pediatric population. Surg Endosc 2003; 17: 730 – 3
Oka T, Kurkchubasche AG, Bussey JG Wesselhoeft CW, Tracy TF, Luks FI. Open and laparoscopic appendectomy are equally safe and acceptable in children. Surg Endosc 2004; 18: 242 – 5
Serour F, Witzling M, Gorenstein A. Is laparoscopic appendectomy in children associated with an uncommon postoperative complication? Surg Endosc 2005; 19: 912 – 22
Tsao KJ, St Peter SD, Valusek PA, Keckler SJ, Sharp S, Holcomb GW 3rd, Snyder CL, Ostile DJ. Adhesive small bowel obstruction after appendectomy in children: comparison between the laparoscopic and open approach. J Pediatr Surg 2007; 42: 939 – 42
Vegunta RK, Ali A, Wallace LJ, Switzer DM, Pearl RH. Laparoscopic appendectomy in children: technically feasible and safe in all stages of acute appendicitis. Am Surg 2004; 70: 198 – 201
Faruquzzaman, Mazumder SK. Complicated appendectomy in children in relation to laparoscopic vs open procedures. Bratisl Lek Listy 2010; 111: 610 – 5
Lintula H, Kokki H, Vanamo K, Antila P, Eskelinen M. Laparoscopy in children with complicated appendicitis. J Pediatr Surg 2002; 37: 317 – 20
Miyano G, Okazaki T, Kato Y, Marusasa T, Takahashi T, Lane GJ, Yamataka A. Open versus laparoscopic treatment for pan-peritonitis secondary to perforated appendicitis in children: a prospective analysis. J Laparoendosc Adv Surg Tech A 2010; 20: 655 – 7
Nataraja RM, Bandi A, Clarke SA, Haddad MJ. Comparison of intra-abdominal abscess formation following laparoscopic and open appendicectomy in children. J Laparoendosc Adv Surg Tech A 2010; 20: 391 – 4
Nwokoma NJ, Swindells MG, Pahl K, Mathur AB, Minocha A, Kurlkarni M, Tsang T. Pediatric advance appendicitis: open versus laparoscopic approach. Surg Laparosc Endosc Percutan Tech 2009; 19: 110 – 3
Wang X, Zhang W, Yang X, Shao J, Zhou X, Yuan J. Complicated appendicitis in children: is laparoscopic appendectomy appropriate? A comparative study with open appendectomy – our experience. J Pediatr Surg 2009; 44: 1924 – 7
Yagmurlu A, Vernon A, Barnhart DC, Georgeson KE, Harmon CM. Laparoscpic appendectomy for perforated appendicitis: a comparison with open appendectomy. Surg Endosc 2006; 20: 1051 – 4
Fleming FJ, Kim MJ, Messing S, Gunzler D, Salloum R, Monson JR. Balancing the risk of postoperative surgical infections: a multivariate analysis of factors associated with laparoscopic appendectomy from the NSQIP database. Ann Surg 2010; 252: 895 – 900
Guller U, Hervey S, Purves H, Muhlbaier LH, Peterson ED, Eubanks S, Pietrobon R. Laparoscopic versus open appendectomy: outcomes comparison based on a large administrative database. Ann Surg 2004; 239: 43 – 52
Romy S, Eisenring MC, Bettschart V, Petignat C, Francioli P, Troillet N. Laparoscope using and surgical site infections in digestive surgery. Ann Surg 2008; 247: 627 – 32
Krisher SL, Browne A, Dibbins A, Tkacz N, Curci M. Intra-abdominal abscess after laparoscopic appendectomy for perforated appendicitis. Arch Surg 2001; 136: 438 – 41
Paik PS, Towson JA, Anthone GJ, Ortega AE, Simons AJ, Beart RW Jr. Intra-abdominal abscesses following laparoscopic and open appendectomies. J Gastrointest Surg 1997; 1: 188 – 92
Horwitz JR, Custer MD, May JR, Mehall JR, Laily KP. Should laparoscopic appendectomy be avoided for complicated appendicitis in children? J Pediatr Surg 1997; 32: 1601 – 3
Khalili TM, Hiatt JR, Savar A, Lau C, Marguiles DR. Perforated appendicitis is not a contraindication to laparoscopy. Am Surg 1999; 65: 965 – 7
Katkhouda N, Friedlander MH, Grant SW, Achanta KK, Essani R, Paik P, Velmahos G, Campos G, Mason R, Mavor E. Intraabdominal abscess rate after laparoscopic appendectomy. Am J Surg 2000; 180: 456 – 9
Wei B, Qi CL, Chen TF, Zheng ZH, Huang JL, Hu BG, Wei HB. Laparoscopic versus open appendectomy for acute appendicitis: a metaanalysis. Surg Endosc 2011; 25: 1199 – 208
Piskun G, Kozik D, Raipal S, Shaftan G, Fogler R. Comparison of laparoscopic, open, and converted appendectomy for perforated appendicitis. Surg Endosc 2001; 15: 660 – 2
Chu T, Chandhoke RA, Smith PC, Schwaitzberg SD. The impact of surgeon choice on the cost of performing laparoscopic appendectomy. Surg Endosc 2011; 25: 1187 – 91
Hsieh CS, Chen YL, Lee MH, Chang HC, Chen ST, Kuo SJ. A lower costly laparoscopic appendectomy: our experience of more than 2000 cases. Int J Surg 2010; 8: 140 – 3
Rosin D, Zmora O, Hoffman A, Khaikin M, Bar Zakai B, Munz Y, Shabtai M, Ayalon A. Low incidence of adhesion-related bowel obstruction after laparoscopic colorectal surgery. J Laparoendosc Adv Surg Tech A. 2007; 17: 604 – 7
Andersson RE. Small bowel obstruction after appendicectomy. Br J Surg 2001; 88: 1387 – 91
Leung TT, Dixon E, Gill M, Mador BD, Moulton KM, Kaplan GG, MacLean AR. Bowel obstruction following appendectomy: what is the true incidence? Ann Surg 2009; 250: 51 – 3
Conflicts of Interests
None.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Markar, S.R., Blackburn, S., Cobb, R. et al. Laparoscopic Versus Open Appendectomy for Complicated and Uncomplicated Appendicitis in Children. J Gastrointest Surg 16, 1993–2004 (2012). https://doi.org/10.1007/s11605-012-1962-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11605-012-1962-y