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Large Volume Hepatic Microwave Ablation Elicits Fewer Pulmonary Changes than Radiofrequency or Cryotherapy

  • Original Article
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Journal of Gastrointestinal Surgery Aims and scope

Abstract

Background

Lung changes after microwave tissue ablation (MTA) of different volumes of liver were compared with hepatic resection, cryotherapy (CRYO) and radiofrequency ablation (RFA).

Methods

Live rats underwent MTA, surgical resection, CRYO or RFA of 15%, 33% and 66% of total hepatic volume and lung samples were collected at the time of death. Lung impairment was assessed directly by examining the tissue specimens for the degree of interstitial pneumonia and by comparing the alveolar thickness in the different groups.

Results

All RFA and CRYO rats undergoing 66% of ablations died, but the MTA group had no fatalities. Following 66% RFA or CRYO ablations, the animals had a significantly increased thickness of the alveolar septa compared to 15% or 33% ablations and to 66% ablations in the MTA group.

Conclusions

Large volume MTA is associated with a significant reduction in consequent lung damage and is well tolerated compared to RFA and CRYO.

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Authors and Affiliations

  1. Department of Hepatobiliary and Pancreatic Surgery, Leicester Royal Infirmary, Leicester, UK

    Fateh Ahmad, Neil Bhardwaj, Andrew Strickland, Rizwan Basit & David M. Lloyd

  2. Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Gwendolen Road, Leicester, LE5 4PW, UK

    Gianpiero Gravante & Ashley R. Dennison

  3. Department of Histopathology, Leicester Royal Infirmary, Leicester, UK

    Kevin West

  4. Laboratory of Biometry, Department of Human Physiology, University of Tor Vergata, Rome, Italy

    Roberto Sorge

Authors
  1. Fateh Ahmad
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  2. Gianpiero Gravante
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  3. Neil Bhardwaj
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  4. Andrew Strickland
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  5. Rizwan Basit
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  6. Kevin West
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  7. Roberto Sorge
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  8. Ashley R. Dennison
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  9. David M. Lloyd
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Corresponding author

Correspondence to Gianpiero Gravante.

Additional information

Mr. David Lloyd had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

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Ahmad, F., Gravante, G., Bhardwaj, N. et al. Large Volume Hepatic Microwave Ablation Elicits Fewer Pulmonary Changes than Radiofrequency or Cryotherapy. J Gastrointest Surg 14, 1963–1968 (2010). https://doi.org/10.1007/s11605-010-1274-z

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  • DOI: https://doi.org/10.1007/s11605-010-1274-z

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