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Gallstone Formation after Gastric Cancer Surgery

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Journal of Gastrointestinal Surgery Aims and scope

Abstract

Background

Gallstone formation is one of the most common complications after gastric cancer surgery, but the mechanism and etiology for such formation are unclear because of a lack of collective clinical investigation.

Method

We evaluated the influence of various surgical factors on the incidence of gallstone formation after gastrectomy. Gallstone formation was confirmed by ultrasound examinations that were routinely carried out after surgery on a periodic basis.

Results

Gallstone formation occurred in 173 of 672 (25.7%) patients who had undergone gastrectomy with lymph-node dissection for gastric cancer. The types of gastrectomy and reconstruction had no significant effect on the incidence, but the extent of lymph-node dissection was a significant factor (p < 0.001: D1 + α vs. D2 + α; p < 0.01: D2 vs. D2 + α). Gallstones were usually formed within 2 years after gastrectomy, but in most cases, gallstone formation was asymptomatic.

Conclusion

The extent of lymph-node dissection was a significant factor in gallstone formation after gastrectomy; therefore, prophylactic cholecystectomy should be considered in cases of extensive lymph-node dissection.

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References

  1. Hauters P, de Neve de Roden A, Pourbaix A, Aupaix F, Coumans P, Therasse G. Cholelithiasis: a serious complication after total gastrectomy. Br J Surg 1988;75:899–900. doi:10.1002/bjs.1800750923.

    Article  PubMed  CAS  Google Scholar 

  2. Kodama I, Yoshida C, Kofuji K, Ohta J, Aoyagi K, Takeda J. Gallstones and gallbladder disorder after gastrectomy for gastric cancer. Int Surg 1996;81:36–39.

    PubMed  CAS  Google Scholar 

  3. Wu CC, Chen CY, Wu TC, Iiu TJ, P’Eng PK. Cholelithiasis and cholecystitis after gastrectomy for gastric carcinoma: a comparison of lymphadenectomy of varying extent. Hepatogastroenterology 1995;42:867–872.

    PubMed  CAS  Google Scholar 

  4. Rieu PN, Jansen JB, Hopman WP, Joosten HJ, Lamers CB. Effect of partial gastrectomy with Billroth II or Roux-en-Y anastomosis on postprandial and cholecystokinin-stimulated gallbladder contraction and secretion of cholecystokinin and pancreatic polypeptide. Dig Dis Sci 1990;35:1066–1072. doi:10.1007/BF01537576.

    Article  PubMed  CAS  Google Scholar 

  5. Chijiiwa K, Makino I, Kozaki N, Tanaka M. Differences in gallbladder bile lithogenicity in patients after gastrectomy and colectomy. Eur Surg Res 1996;28:1–7. doi:10.1159/000129433.

    Article  PubMed  CAS  Google Scholar 

  6. Nabae T, Yokohata K, Otsuka T, Inoue K, Yamaguchi K, Chijiiwa K, Tanaka M. Effect of truncal vagotomy on sphincter of oddi cyclic motility in conscious dogs. Ann Surg 2002;236:98–104. doi:10.1097/00000658-200207000-00015.

    Article  PubMed  Google Scholar 

  7. Rehnberg O, Haglund U. Gallstone disease following antrectomy and gastroduodenostomy with or without vagotomy. Ann Surg 1985;201:315–318. doi:10.1097/00000658-198503000-00010.

    Article  PubMed  CAS  Google Scholar 

  8. Inoue K, Fuchigami A, Higashide S, Sumi S, Kogire M, Suzuki T, Tobe T. Gallbladder sludge and stone formation in relation to contractile function after gastrectomy. A prospective study. Ann Surg 1992;215:19–26.

    Article  PubMed  CAS  Google Scholar 

  9. Lorusso D, Misciagna G, Noviello MR, Tarantino S. Cholelithiasis after Billroth II gastric resection. Surgery 1988;103:579–583.

    PubMed  CAS  Google Scholar 

  10. Pezzolla F, Lantone G, Guerra V, Misciagna G, Prete F, Giorgio I, Lorusso D. Influence of the method of digestive tract reconstruction on gallstone development after total gastrectomy for gastric cancer. Am J Surg 1993;166:6–10. doi:10.1016/S0002–9610(05)80573–2.

    Article  PubMed  CAS  Google Scholar 

  11. Ikeda Y, Shinchi K, Kono S, Tsuboi K, Sugimachi K. Risk of gallstones following gastrectomy in Japanese men. Surg Today 1995;25:515–518. doi:10.1007/BF00311307.

    Article  PubMed  CAS  Google Scholar 

  12. Kodama M, Koyama K, Chida T, Arakawa A, Tur G. Early postoperative evaluation of pylorus-preserving gastrectomy for gastric cancer. World J Surg 1995;19:456–460. (discussion 461) doi:10.1007/BF00299190.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Gastric Surgery Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan

    Takeo Fukagawa, Hitoshi Katai, Makoto Saka, Shinji Morita, Takeshi Sano & Mitsuru Sasako

Authors
  1. Takeo Fukagawa
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  2. Hitoshi Katai
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  3. Makoto Saka
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  4. Shinji Morita
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  5. Takeshi Sano
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  6. Mitsuru Sasako
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Corresponding author

Correspondence to Takeo Fukagawa.

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Fukagawa, T., Katai, H., Saka, M. et al. Gallstone Formation after Gastric Cancer Surgery. J Gastrointest Surg 13, 886–889 (2009). https://doi.org/10.1007/s11605-009-0832-8

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  • DOI: https://doi.org/10.1007/s11605-009-0832-8

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