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The Effects of Vasopressors on Perfusion of Gastric Graft after Esophagectomy. An Experimental Study

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Journal of Gastrointestinal Surgery Aims and scope

Abstract

Aims

To evaluate the impact of the perioperative administration of norepinephrine on the perfusion of the esophageal graft.

Methods

This is an experimental study. Six swine underwent transhiatal esophagectomy; the stomach was used to replace the resected esophagus. We provoked hemorrhagic shock to the animals and then we administered noradrenaline to restore the blood pressure. We monitored the graft perfusion perioperatively using the technique of microdialysis.

Results

In all animals, the graft experienced severe hypoperfusion after the administration of noradrenaline that was statistically significant.

Conclusions

Our data support the hypothesis that norepinephrine should be used with extreme caution in the perioperative setting after esophagectomy. Further studies, however, will be required to evaluate the clinical significance of this finding.

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Authors and Affiliations

  1. 1st Department of Propaedeutic Surgery, Athens Medical School, University of Athens, “Hippocration” General Hospital of Athens, Athens, Greece

    Dimitrios Theodorou, Panagiotis G. Drimousis, Andreas Larentzakis, Konstantinos G. Toutouzas & Stylianos Katsaragakis

  2. Department of experimental surgery, ELPEN Laboratories, Athens, Greece

    Apostolos Papalois

  3. 11, 3rd September 1843 Str., 12242, Egaleo, Attiki, Greece

    Andreas Larentzakis

Authors
  1. Dimitrios Theodorou
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  2. Panagiotis G. Drimousis
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  3. Andreas Larentzakis
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  4. Apostolos Papalois
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  5. Konstantinos G. Toutouzas
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  6. Stylianos Katsaragakis
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Corresponding author

Correspondence to Andreas Larentzakis.

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Theodorou, D., Drimousis, P.G., Larentzakis, A. et al. The Effects of Vasopressors on Perfusion of Gastric Graft after Esophagectomy. An Experimental Study. J Gastrointest Surg 12, 1497–1501 (2008). https://doi.org/10.1007/s11605-008-0575-y

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  • DOI: https://doi.org/10.1007/s11605-008-0575-y

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