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Undifferentiated Embryonal Sarcoma of the Liver Successfully Treated With Chemotherapy and Liver Resection

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Journal of Gastrointestinal Surgery Aims and scope

Abstract

Undifferentiated embryonal sarcoma is the third most common malignant tumor of the liver in children, accounting for 13% of hepatic malignancies in this age group. It has been considered an aggressive neoplasm with very poor prognosis until the late 1980s, when long-term survivors were reported after multiagent chemotherapy followed by resection. We, herein, report two pediatric cases of undifferentiated embryonal sarcoma treated successfully with surgical resection after neoadjuvant chemotherapy based on therapy used in childhood soft tissue sarcomas and in childhood hepatic malignancies. The first patient also had a concurrent cerebellar tumor (pilocytic astrocytoma), for which he first underwent craniotomy and resection, delaying the liver tumor resection by 10 weeks. They are alive and tumor free at 48 months (case no. 1) and 18 months (case no. 2) following neoadjuvant chemotherapy and liver resection.

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Acknowledgement

This work was supported by a grant from the Loma Linda Transplantation Institute, Loma Linda, CA.

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Authors and Affiliations

  1. Transplantation Institute, Loma Linda University Medical Center and Children’s Hospital, Loma Linda, CA, 92354, USA

    Pedro W. Baron, Ramzi Ben-Youssef & Okechukwu N. Ojogho

  2. Department of Pediatrics, Loma Linda University Medical Center and Children’s Hospital, Loma Linda, CA, 92354, USA

    Fatenah Majlessipour, Antranik A. Bedros & George Yanni

  3. Department of Pathology, Loma Linda University Medical Center and Children’s Hospital, Loma Linda, CA, 92354, USA

    Craig W. Zuppan

  4. Division of Transplantation, Stanford University, Palo Alto, CA, 94304, USA

    Waldo Concepcion

Authors
  1. Pedro W. Baron
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  2. Fatenah Majlessipour
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  3. Antranik A. Bedros
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  4. Craig W. Zuppan
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  5. Ramzi Ben-Youssef
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  6. George Yanni
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  7. Okechukwu N. Ojogho
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  8. Waldo Concepcion
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Correspondence to Pedro W. Baron.

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Baron, P.W., Majlessipour, F., Bedros, A.A. et al. Undifferentiated Embryonal Sarcoma of the Liver Successfully Treated With Chemotherapy and Liver Resection. J Gastrointest Surg 11, 73–75 (2007). https://doi.org/10.1007/s11605-006-0044-4

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  • DOI: https://doi.org/10.1007/s11605-006-0044-4

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