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HRCT texture analysis for pure or part-solid ground-glass nodules: distinguishability of adenocarcinoma in situ or minimally invasive adenocarcinoma from invasive adenocarcinoma

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Japanese Journal of Radiology Aims and scope Submit manuscript

Abstract

Purpose

To distinguish between adenocarcinoma in situ (AIS)–minimally invasive adenocarcinoma (MIA) and invasive adenocarcinoma (IAC) showing pure or part-solid ground-glass nodules (GGNs) by high-resolution computed tomography (HRCT) texture analysis.

Materials and methods

This retrospective study included 101 consecutive patients with 115 pure or part-solid GGNs ≤ 3 cm diameter, which were surgically resected and pathologically diagnosed with AIS, MIA, or IAC (48 AIS–MIA and 67 IAC) between April 2011 and March 2015. Each tumor was manually segmented on axial CT images, and the following texture features were calculated: volume, mass, mean CT value, variance, skewness, kurtosis, entropy, uniformity, and percentile CT numbers (10th, 25th, 50th, 75th, 90th, 95th percentiles). The differences between AIS–MIA and IAC were statistically evaluated using univariate, multivariate, and receiver operating characteristic analysis.

Results

Compared with IAC, AIS–MIA had significantly greater skewness, kurtosis, and uniformity, whereas in the other parameters, AIS–MIA demonstrated significantly lower values than those of IAC. Multivariate analysis revealed that independent differentiators were the 90th percentile CT numbers (P < 0.001) and entropy (P = 0.005) with an excellent accuracy (area under the curve, 0.90).

Conclusions

The 90th percentile CT numbers and entropy can accurately distinguish AIS–MIA from IAC.

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Funding

This work was supported by JSPS KAKENHI grant number JP17K10352.

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Authors and Affiliations

  1. Department of Radiology and Radiation Oncology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan

    Takuya Yagi, Motohiko Yamazaki, Rei Ogawa, Hiroyuki Ishikawa, Norihiko Yoshimura & Hidefumi Aoyama

  2. Histopathology Core Facility, Niigata University Faculty of Medicine, Niigata, Japan

    Riuko Ohashi

  3. Division of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan

    Masanori Tsuchida

  4. Division of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan

    Yoichi Ajioka

Authors
  1. Takuya Yagi
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  2. Motohiko Yamazaki
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  3. Riuko Ohashi
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  4. Rei Ogawa
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  5. Hiroyuki Ishikawa
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  6. Norihiko Yoshimura
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  7. Masanori Tsuchida
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  8. Yoichi Ajioka
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  9. Hidefumi Aoyama
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Corresponding author

Correspondence to Motohiko Yamazaki.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical statement

An institutional review board approved this retrospective study and waived the requirement for informed consent.

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Yagi, T., Yamazaki, M., Ohashi, R. et al. HRCT texture analysis for pure or part-solid ground-glass nodules: distinguishability of adenocarcinoma in situ or minimally invasive adenocarcinoma from invasive adenocarcinoma. Jpn J Radiol 36, 113–121 (2018). https://doi.org/10.1007/s11604-017-0711-2

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  • DOI: https://doi.org/10.1007/s11604-017-0711-2

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