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Neurite orientation dispersion and density imaging for evaluation of corticospinal tract in idiopathic normal pressure hydrocephalus

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Abstract

Purpose

To evaluate diffusional changes of the corticospinal tract (CST) in patients with idiopathic normal pressure hydrocephalus (iNPH) by neurite orientation dispersion and density imaging (NODDI).

Materials and methods

Nineteen patients with iNPH and 12 healthy controls were included. Diffusion MRI data for NODDI were acquired with a 3-T system, using 32 motion-probing gradient directions with six b-values (from 0 to 2500 s/mm2). The orientation dispersion index (ODI), intra-cellular volume fraction (Vic), and isotropic volume fraction (Viso) of the CST were calculated by tract-specific analysis in patients and controls. We also measured the fractional anisotropy (FA) and apparent diffusion coefficient (ADC).

Results

The ODI of the CST (0.087 ± 0.024 vs. 0.183 ± 0.051, P < 0.01, Mann-Whitney U test) and Vic of the CST (0.551 ± 0.061 vs. 0.628 ± 0.038, P < 0.01, Mann-Whitney U test) were significantly lower in iNPH patients than in healthy controls. In receiver-operating characteristic analysis, the area under the curve (AUC) of the ODI and FA were not significantly different (Fig. 4a, 0.987 vs. 0.904, P = 0.061), and the AUC of the Vic and ADC also showed no significant difference (Fig. 4b, 0.864 vs. 0.912, P = 0.194).

Conclusion

The NODDI can effectively evaluate the condition of neurites in the CST of iNPH patients, and the ODI could be clinically useful in the diagnosis of iNPH.

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Acknowledgements

This study was supported by a Research Grant from the Ministry of Health, Labor and Welfare of Japan (2014-Nanchi-General-052), supported by the program for Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS) from the Japan Agency for Medical Research and Development and funded by the ImPACT Program of the Council for Science, Technology and Innovation (Cabinet Office, Government of Japan).

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Authors and Affiliations

  1. Department of Radiology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan

    Ryusuke Irie, Masaaki Hori, Michimasa Suzuki, Koji Kamagata, Atsushi Nakanishi & Shigeki Aoki

  2. Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

    Kouhei Kamiya

  3. Department of Radiological Sciences, Tokyo Metropolitan University Graduate School of Human Health Sciences, Tokyo, Japan

    Kohei Tsuruta

  4. Department of Neurosurgery, Juntendo University School of Medicine, Tokyo, Japan

    Madoka Nakajima, Masakazu Miyajima & Hajime Arai

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  1. Ryusuke Irie
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  2. Kohei Tsuruta
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  3. Masaaki Hori
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  4. Michimasa Suzuki
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  7. Kouhei Kamiya
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  8. Madoka Nakajima
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Correspondence to Ryusuke Irie.

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The authors declare that they have no conflict of interest.

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Informed consent was obtained from all individual participants included in the study.

Ethical statement

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Irie, R., Tsuruta, K., Hori, M. et al. Neurite orientation dispersion and density imaging for evaluation of corticospinal tract in idiopathic normal pressure hydrocephalus. Jpn J Radiol 35, 25–30 (2017). https://doi.org/10.1007/s11604-016-0594-7

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  • DOI: https://doi.org/10.1007/s11604-016-0594-7

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