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Different enhancement of the hepatic parenchyma in dynamic CT for patients with normal liver and chronic liver diseases and with the dose of contrast medium based on body surface area

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Abstract

Purpose

The purpose of this study was to characterize hepatic parenchymal enhancement for normal and diseased liver in dynamic computed tomography (CT) with the dose of contrast medium calculated on the basis of body surface area (BSA).

Materials and methods

The records of 328 consecutive patients who underwent triple-phase contrast-enhanced CT were retrospectively reviewed. The patients were divided into four groups: normal liver (n = 125), chronic hepatitis (CH) (n = 92), Child–Pugh grade A liver cirrhosis (LC-A) (n = 78), and Child–Pugh grade B liver cirrhosis (LC-B) (n = 33). All patients received 22 g I m−2 as contrast material, calculated on the basis of BSA. CT values were measured in the region of interest during the pre-contrast, arterial, and portal phases, and the change in the CT value (ΔHU, where HU is Hounsfield units) compared with pre-contrast images was calculated.

Results

Mean ΔHU for the hepatic parenchyma for the normal liver, CH, LC-A, and LC-B groups during the portal phase was 55.5 ± 11.8 HU, 55.2 ± 12.5 HU, 50.0 ± 13.0 HU, and 43.0 ± 12.7 HU, respectively; generalized estimating equation analysis showed the differences were significant (p < 0.01).

Conclusion

Hepatic parenchymal enhancement during the portal phase decreased as the severity of chronic liver damage increased.

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Conflict of interest

The authors declare that they have no conflict of interest.

Funding

This study was not funded by any entity.

Informed consent

For this retrospective study the requirement for informed consent was waived by the institutional review board.

Ethical standard

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee, and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Authors and Affiliations

  1. Department of Radiology, Ehime University Graduate School of Medicine, 454 Shitukawa, Toon, Ehime, 791-0925, Japan

    Gen Koiwahara, Takaharu Tsuda, Megumi Matsuda, Masaaki Hirata, Hiroaki Tanaka, Teruhito Kido & Teruhito Mochizuki

  2. Department of Radiology, Kinki University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka, 589-8511, Japan

    Tomoko Hyodo

Authors
  1. Gen Koiwahara
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  2. Takaharu Tsuda
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  3. Megumi Matsuda
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  4. Masaaki Hirata
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  5. Hiroaki Tanaka
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  7. Teruhito Kido
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  8. Teruhito Mochizuki
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Correspondence to Gen Koiwahara.

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Koiwahara, G., Tsuda, T., Matsuda, M. et al. Different enhancement of the hepatic parenchyma in dynamic CT for patients with normal liver and chronic liver diseases and with the dose of contrast medium based on body surface area. Jpn J Radiol 33, 194–200 (2015). https://doi.org/10.1007/s11604-015-0398-1

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  • DOI: https://doi.org/10.1007/s11604-015-0398-1

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