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Cutaneous complications after transcatheter arterial treatment for hepatocellular carcinoma via the internal mammary artery: how to avoid this complication

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Japanese Journal of Radiology Aims and scope Submit manuscript

Abstract

Purpose

To lower the rate of cutaneous complications after transcatheter arterial treatment for hepatocellular carcinoma (HCC) via the internal mammary artery (IMA) we retrospectively assessed the complications.

Materials and methods

We reviewed cutaneous complications in 14 patients with 18 HCCs who had undergone 17 treatment procedures via the IMA, including selective transcatheter arterial infusion chemotherapy with Lipiodol (Lip-TAI) (n = 3), selective Lip-TAI + transcatheter arterial embolization (TAE) (n = 3), nonselective Lip-TAI (n = 1), nonselective Lip-TAI + TAE (n = 5), and nonselective TAE (n = 5). The filling and nonfilling of subcutaneous vessels with Lipiodol was examined on postoperative computed tomography (CT) scans.

Results

Skin rash (n = 3) and ulceration (n = 1) occurred after 4 of 17 (24%) procedures: two of three selective Lip-TAI procedures and two of five nonselective Lip-TAI + TAE procedures. The doses of chemotherapeutic agents for tumor sizes in selective Lip-TAI procedures were higher than those in selective Lip-TAI + TAE procedures. Cutaneous complications were encountered after two of three procedures with filling but not after any of eight procedures without filling.

Conclusion

A lower dose of chemotherapeutic agents may be less risky when undertaking a selective procedure via the IMA for HCC. If nonselective, TAE alone may be less risky. Postoperative CT may be helpful for predicting cutaneous complications.

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Authors and Affiliations

  1. Department of Radiology, Hiroshima City Hospital, Hiroshima, Japan

    Kenji Kajiwara

  2. Department of Diagnostic Radiology, Hiroshima University Hospital, 1-2-3 Kasumi-cho, Minami-ku, Hiroshima, 734-8551, Japan

    Hideaki Kakizawa, Masashi Hieda, Masaki Ishikawa, Keizo Tanitame, Chihiro Tani & Kazuo Awai

  3. Department of Radiology, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan

    Naoko Takeuchi & Naoyuki Toyota

  4. Department of Diagnostic Radiology, JA Hiroshima General Hospital, Hatsukaichi, Japan

    Takayuki Suzuki & Koichi Fujikawa

  5. Department of Medicine and Molecular Science, Hiroshima University Hospital, Hiroshima, Japan

    Hiroshi Aikata & Kazuaki Chayama

Authors
  1. Kenji Kajiwara
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  2. Hideaki Kakizawa
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  3. Naoko Takeuchi
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  4. Naoyuki Toyota
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  5. Masashi Hieda
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  6. Masaki Ishikawa
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  7. Keizo Tanitame
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  8. Chihiro Tani
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  9. Takayuki Suzuki
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  10. Koichi Fujikawa
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  11. Hiroshi Aikata
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  12. Kazuaki Chayama
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  13. Kazuo Awai
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Corresponding author

Correspondence to Hideaki Kakizawa.

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Cite this article

Kajiwara, K., Kakizawa, H., Takeuchi, N. et al. Cutaneous complications after transcatheter arterial treatment for hepatocellular carcinoma via the internal mammary artery: how to avoid this complication. Jpn J Radiol 29, 307–315 (2011). https://doi.org/10.1007/s11604-011-0559-9

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  • DOI: https://doi.org/10.1007/s11604-011-0559-9

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