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Structure and Anti-HIV Activity of Betulinic Acid Analogues

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Summary

Firstly discovered in 1980s, human immunodeficiency virus (HIV) continues to affect more and more people. However, there is no effective drug available for the therapy of HIV infection. Betulinic acid existing in various medicinal herbs and fruits exhibits multiple biological effects, especially its outstanding anti-HIV activity, which has drawn the attentions of many pharmacists. Among the derivatives of betulinic acid, some compounds exhibited inhibitory activities at the nanomolar concentration, and have entered phase II clinical trials. This paper summarizes the current investigations on the anti-HIV activity of betulinic acid analogues, and provides valuable data for subsequent researches.

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Author notes

  1. Both authors contributed equally to this work.

Authors and Affiliations

  1. University of South China, Hengyang, 421001, China

    Qiu-xia Huang, Hong-fei Chen, Xing-rui Luo, Yin-xiang Zhang, Xu Yao & Xing Zheng

  2. Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, 42100, China

    Qiu-xia Huang, Hong-fei Chen, Xing-rui Luo, Yin-xiang Zhang, Xu Yao & Xing Zheng

Authors
  1. Qiu-xia Huang
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  2. Hong-fei Chen
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  3. Xing-rui Luo
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  4. Yin-xiang Zhang
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  5. Xu Yao
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  6. Xing Zheng
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Corresponding authors

Correspondence to Xu Yao or Xing Zheng.

Additional information

This research was supported by the National Natural Science Foundation of China (No. 81273537), Scientific Research Fund of Education Department of Hunan Province (No. 17Al90), the Key Project of Science and Technology Department of Hunan Province (No. 2016DK2001), and the Key Disciplines of Hunan Province and the Zhengxing Scholar Program of the University of South China.

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Huang, Qx., Chen, Hf., Luo, Xr. et al. Structure and Anti-HIV Activity of Betulinic Acid Analogues. CURR MED SCI 38, 387–397 (2018). https://doi.org/10.1007/s11596-018-1891-4

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  • DOI: https://doi.org/10.1007/s11596-018-1891-4

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