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Electrochemical behavior and DNA-binding properties of binuclear copper(II) complex containing mixed ligands of N-hydroxyethylaminoethyl oxamido and 2,2′-bipyridine

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Abstract

The electrochemical property of dinuclear copper(II) complex containing mixed ligands of N-hydroxyethylaminoethyl oxamido and 2,2′-bipyridine [Cu2(bpy)2(HAO) 2+2 ] was studied with cyclic voltammetry. Cu2(bpy)2(HAO) 2+2 had irreversible oxidation peaks in 0.1 mol/L NaCl solution at the stearic acid-modified carbon paste electrode. Cyclic voltammetry and absorption spectra measurements were used to study the interaction between Cu2(bpy)2(HAO) 2+2 and herring fish sperm DNA. All the experimental results showed that Cu2(bpy)2(HAO) 2+2 interacted with DNA mainly through electrostatic affinity to make tiny difference between Cu2(bpy)2(HAO) 2+2 –ssDNA and Cu2(bpy)2(HAO) 2+2 –dsDNA. The binding ratio and the binding constant of DNA–Cu2(bpy)2(HAO) 2+2 were calculated as 1:1 and 6.41 × 104, respectively. The redox peak current of Cu2(bpy)2(HAO) 2+2 decreased markedly after its interaction with DNA. This was used to detect the concentration of DNA quantitatively.

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Authors and Affiliations

  1. Key Laboratory of Eco-chemical Engineering, Ministry of Education; College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, 266042, Qingdao, China

    Guiyun Xu, Lin Tang & Hongtian Liu

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  1. Guiyun Xu
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  2. Lin Tang
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  3. Hongtian Liu
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Correspondence to Guiyun Xu.

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Xu, G., Tang, L. & Liu, H. Electrochemical behavior and DNA-binding properties of binuclear copper(II) complex containing mixed ligands of N-hydroxyethylaminoethyl oxamido and 2,2′-bipyridine. Ionics 19, 309–314 (2013). https://doi.org/10.1007/s11581-012-0721-0

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  • DOI: https://doi.org/10.1007/s11581-012-0721-0

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