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Exploring Potential of Aspergillus sclerotiorum: Secondary Metabolites and Biotechnological Relevance

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Abstract

Fungi have been proven to be an inexhaustible treasure for structural-unique bioactive metabolites. Aspergillus sclerotiorum (Aspergillaceae) is a source of different enzymes that could have potential biotechnological and industrial applications. Also, this fungus has the capacity to biosynthesize different metabolites: pyrazines, cyclic peptides, indole derivatives, diketopiperazines, butenolides, and lovastatin analogs with diversified bioactivities. It is noteworthy that diketopiperazines and butenolides are the most bioactive metabolites that possessed marked antimicrobial and cytotoxic potentials. The current review aims to discuss the metabolites produced by A. sclerotiorum, including their structures, bioactivities, and proposed biosynthesis, as well as the biotechnological applications of this fungus in the period from 1958 to September 2022. A total of 104 metabolites and 91 references have been listed.

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Abbreviations

A-549:

human lung adenocarcinoma epithelial cell line

ACC-MESO-1:

malignant pleural mesothelioma

Akt:

serine/threonine protein kinase B

AMPK:

AMP-dependent kinase serine

Caco-2:

human colon cancer cell lines

CC:

column chromatography

CCK-8:

cell counting kit-8

CD:

circular dichroism

CFTR:

cystic fibrosis transmembrane conductance regulator

cGMP:

cyclic guanosine monophosphate

ECD:

electronic circular dichroism

GFP:

green fluorescent protein-based fluorescent detection

HeLa:

human cervical epitheloid carcinoma cell line

HepG2:

human hepatocellular liver carcinoma cell line

HL-60:

human promyelocytic leukemia cell line

HL-7702:

human normal liver

HMGR:

hydroxymethylglutaryl-coenzyme A reductase

HONE1:

human nasopharyngeal carcinoma cell lines

HONE-EBV:

human nasopharyngeal carcinoma cell line

HNRPS:

hybrid polyketide- non-ribosomal peptide synthase

Huh-7:

human hepatoma cell line

IC50 :

half-maximal inhibitory concentration

IL-1β:

interleukin-1β

IZD:

inhibition zone diameter

KB:

human oral epidermoid carcinoma cell line

LC50 :

lethal concentration 50

LC-MS:

liquid chromatography mass spectrometry

LDH:

lactate dehydrogenase

LXRα:

liver X receptor alpha

MCF-7:

breast cancer cells

MIC:

minimum inhibitory concentration

MPLC:

medium pressure liquid chromatography

MTT:

3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide

NAFLD:

non-alcoholic fatty liver disease

NO:

nitric oxide

NOE-DIFF:

nuclear overhauser effect difference spectroscopy

NPC1L1:

Niemann-pick c1-like 1

NRPS:

non-ribosomal peptide synthase

PKS:

polyketide synthase

ODS:

octadecylsilyl

OSMAC:

one strain many compounds

SiO2 CC:

silica gel column

SmF:

submerged fermentation

SMMC-7721:

human hepatoma cell line

SRB:

sulforhodamine B

SSF:

solid-state fermentation

U937:

pro-monocytic, human myeloid leukaemia cell line

Vero:

African green monkey kidney fibroblast cells

WST-8:

water-soluble tetrazolium 8

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Authors and Affiliations

  1. Department of Chemistry, Preparatory Year Program, Batterjee Medical College, Jeddah, 21442, Saudi Arabia

    Sabrin R. M. Ibrahim

  2. Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt

    Sabrin R. M. Ibrahim

  3. Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah, 21589, Saudi Arabia

    Hossam M. Abdallah & Gamal A. Mohamed

  4. Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt

    Hossam M. Abdallah

  5. Research & Development Division, Greenvention Biotech Pvt. Ltd., Uruli-Kanch, Maharashtra, 412202, India

    Sunil K. Deshmukh

  6. Agpharm Bioinnovations LLP, Incubatee: Science and Technology Entrepreneurs Park (STEP), Thapar Institute of Engineering and Technology, Patiala, Punjab, 147004, India

    Sunil K. Deshmukh

Authors
  1. Sabrin R. M. Ibrahim
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  2. Hossam M. Abdallah
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  3. Gamal A. Mohamed
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  4. Sunil K. Deshmukh
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Contributions

Conceptualization: (S.R.M.I, S.K.D.), literature search and compilation: (H.M.A., G.A.M.); writing abstract, introduction, conclusion, proof reading: (S.R.M.I., H.M.A., G.A.M., S.K.D.). Preparation of data tables: (S.R.M.I, G.A.M., S.K.D.). Generating structures: H.M.A., G.A.M. Overall compilation and coordination: (S.R.M.I, S.K.D.). All authors have read and agreed to the published version of the manuscript.

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Correspondence to Sunil K. Deshmukh.

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Ibrahim, S.R.M., Abdallah, H.M., Mohamed, G.A. et al. Exploring Potential of Aspergillus sclerotiorum: Secondary Metabolites and Biotechnological Relevance. Mycol Progress 22, 8 (2023). https://doi.org/10.1007/s11557-022-01856-3

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  • DOI: https://doi.org/10.1007/s11557-022-01856-3

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