Abstract
Dupuytren’s Disease (DD) is a common, fibroproliferative disorder affecting the palmar surface of the hands which is often irreversible and progressive. Understanding the epidemiology of DD is important in order to provide clues to its etiopathogenesis. This review aims to evaluate the epidemiological studies carried out in DD since 1951. Studies evaluating the epidemiology of DD were searched using Medline, Pubmed, and Scopus which dated back from 1951 to current date. Inclusion criteria were any studies investigating the prevalence or incidence of DD in any population group. A total of 620 articles were cited. Forty-nine studies were subsequently identified as relevant to evaluating the epidemiology of DD. The prevalence of DD in all studies increased with age with a male to female ratio of approximately 5.9:1. Prevalence rates ranged from 0.2% to 56% in varying age, population groups, and methods of data collection. The highest prevalence rate was reported in a study group of epileptic patients. Although, only one study calculated the incidence (as opposed to prevalence) of DD to be equal to 34.3 per 100,000 men (0.03%). In conclusion, the prevalence of DD in different geographical locations is extremely variable, and it is not clear whether this is genetic, environmental, or a combination of both. The majority of the prevalence studies have been conducted in Scandinavia or the UK, and the vast changes in population structure, the changes in prevalence of associated diseases, and the change in diagnostic criteria of DD makes understanding the epidemiology of this condition difficult.
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Abe Y, Rokkaku T, Ebata T, et al. Dupuytren’s disease following acute injury in Japanese patients: Dupuytren’s disease or not? J Hand Surg [Br] 2007. 32(5):569–72. doi:10.1016/j.jhse.2007.06.005.
Aladin A, Oni JA. Bilateral Dupuytren’s contracture in a black patient. Int J Clin Pract 2001;55(9):641–2.
Arafa M, Noble J, Royle SG, Trail IA, Allen J. Dupuytren’s and epilepsy revisited. J Hand Surg [Br] 1992. 17(2):221–4. doi:10.1016/0266-7681(92)90095-J.
Arafa M, Steingold RF, Noble J. The incidence of Dupuytren’s disease in patients with rheumatoid arthritis. J Hand Surg [Br] 1984. 9(2):165–6. doi:10.1016/S0266-7681(84)80020-0.
Ardic F, Soyupek F, Kahraman Y, Yorgancioglu R. The musculoskeletal complications seen in type II diabetics: predominance of hand involvement. Clin Rheumatol 2003. 22:229–33. doi:10.1007/s10067-003-0704-7.
Arkkila PE, Kantola IM, Viikari JS. Dupuytren’s disease: Association with chronic diabetic complications. J Rheumatol 1997;24:153–9.
Arkkila PE, Kantola IM, Viikari JSA, Ronnemaa T, Vahatalo MA. Dupuytren’s disease in type 1 diabetic patients: A 5-year prospective study. Clin Exp Rheumatol 1996;14:59–65.
Bayat A, McGrouther DA. Management of Dupuytren's disease–clear advice for an elusive condition. Ann R Coll Surg Engl 2006. 88(1):3–8. doi:10.1308/003588406X83104.
Bebbington A, Savage R. Dupuytren’s disease in an infant. J Bone Joint Surg Br 2005;87B(1):111–3.
Bergenudd H, Lindgarde F, Nilsson BE. Prevalence of Dupuytren’s contracture and its correlation with degenerative changes of the hands and feet and with criteria of general health. J Hand Surg [Br] 1993. 18B:254–7. doi:10.1016/0266-7681(93)90123-W.
Bonnici AV, Birjandi F, Spencer JD, Fox SP, Berry AC. Chromosomal abnormalities in Dupuytren’s contracture and carpal tunnel syndrome. J Hand Surg [Br] 1992. 17(3):349–55. doi:10.1016/0266-7681(92)90128-O.
Bovenzi M. Hand-arm vibration syndrome and dose-response relation for vibration induced white finger among quarry drillers and stonecarvers. Italian Study Group on Physical Hazards in the Stone Industry. Occup Environ Med 1994;51(9):603–11.
Bower M, Nelson M, Gazzard BG. Dupuytren’s contractures in patients infected with HIV. BMJ 1990;300:164–5.
Burge P, Hoy G, Regan P, Milne R. Smoking, alcohol and the risk of Dupuytren’s contracture. J Bone Joint Surg 1997;79(B):206–10.
Burge P. Genetics of Dupuytren’s disease. Hand Clin 1999;15(1):63–71.
Burke FD, Proud G, Lawson IJ, McGeoch KL, Miles NV. An assessment of the effects of exposure to vibration, smoking, alcohol and diabetes on the prevalence of Dupuytren’s disease in 97537 miners. J Hand Surg [Br] 2007. 32E(4):400–6. doi:10.1016/j.jhse.2005.02.002.
Carson J, Clarke C. Dupuytren’s contracture in pensioners at the Royal Hospital Chelsea. J R Coll Physicians Lond 1993;27(1):25–7.
Chammas M, Bousquet P, Renard E, et al. Dupuytren’s disease, carpal tunnel syndrome, trigger finger, and diabetes mellitus. J Hand Surg [Am] 1995. 20(1):109–14. doi:10.1016/S0363-5023(05)80068-1.
Critchley EM, Vakil SD, Hayward HW, Owen VM. Dupuytren’s disease in epilepsy: result of prolonged administration of anticonvulsants. J Neurol Neurosurg Psychiatry 1976. 39(5):498–503. doi:10.1136/jnnp.39.5.498.
Dasgupta AK, Harrison J. Effects of vibration on the hand-arm system of miners in India. Occup Med 1996;46(1):71–8.
de la Caffiniere JY, Wagner R, Etscheid J, Metzger F. Manual labour and Dupuytrens disease. The results of a computerized survey in the field of iron metallurgy. Ann Chir Main 1983. 2(1):66–72. doi:10.1016/S0753-9053(83)80084-2.
Dunstan DW, Zimmet PZ, Welborn TA, et al. The rising prevalence of diabetes and impaired glucose tolerance: The Australian Diabetes, Obesity and Lifestyle study. Diabetes Care 2002. 25(5):829–34. doi:10.2337/diacare.25.5.829.
Dupuytren BG. Permanent retraction of the fingers, produced by an affection of the palmar fascia. Lancet 1833;34(2):222.
Eadington DW, Patrick AW, Collier A, Frier BM. Limited joint mobility, Dupuytren’s contracture and retinopathy in type 1 diabetes: association with cigarette smoking. Diabet Med 1989;6(2):152–7.
Eadington DW, Patrick AW, Frier BM. Association between connective tissue changes and smoking habit in type 2 diabetes and in non-diabetic humans. Diabetes Res Clin Pract 1991. 11(2):121–5. doi:10.1016/0168-8227(91)90101-I.
Early PF. Population studies in Dupuytren’s contracture. J Bone Joint Surg 1962;44B(3):602–13.
Egawa T, Senrui H, Horiki A, et al. Epidemiology of the Oriental patient. In: Mcfarlane RM, McGrouther DA, Flint MH, editors. Dupuytren’s Disease. Edinburgh: Churchill Livingstone; 1990. p. 239–45.
Egawa T. Dupuytren’s contracture in Japan: Incidental study on outpatients in a private practice of general orthopaedics. J Jpn Soc Surg Hand 1985;2:204–7.
Elliot D. The early history of Dupuytren’s disease. Hand Clin 1999;15:1–19.
Erdmann MW, Quaba AA, Sommerlad BC. Epithelioid sarcoma masquerading as Dupuytren’s disease. Br J Plast Surg 1995. 48(1):39–42. doi:10.1016/0007-1226(95)90029-2.
Finsen V, Dalen H, Nesheim J. The prevalence of Dupuytren’s disease among 2 different ethnic groups in Northern Norway. J Hand Surg [Am] 2002;27(1):115–7.
French PD, Kitchen VS, Harris JRW. Prevalence of Dupuytren’s contracture in patients infected with HIV. BMJ 1990;301:967.
Friedman GD Primer of epidemiology. 5th ed. McGraw-Hill; 2004. pp. 1-5.
Furnas DW. Dupuytren’s contracture in a black patient in East Africa. Plast Reconstr Surg 1979. 64:250–1. doi:10.1097/00006534-197908000-00021.
Geohegan JM, Forbes J, Clark DI, Smith C, Hubbard R. Dupuytren’s disease risk factors. J Hand Surg [Br] 2004. 29B(5):423–6. doi:10.1016/j.jhsb.2004.06.006.
Godtfredsen NS, Lucht H, Prescott E, Sorensen TI, Gronbaek M. A prospective study linked both alcohol and tobacco to Dupuytren’s disease. J Clin Epidemiol 2004. 57(8):858–63. doi:10.1016/j.jclinepi.2003.11.015.
Gonzalez MH, Sobeski J, Grindel S, Chunprapah B, Weinzweig N. Dupuytren’s disease in African-Americans. J Hand Surg [Br] 1998. 23(3):306–7. doi:10.1016/S0266-7681(98)80046-6.
Gordon S. Dupuytren’s contracture. The significance of various factors in its etiology. Ann Surg 1954;5:683–6.
Gudmundsson KG, Arngrimsson F, Sigfusson N, Jonsson T. Increased total mortality and cancer mortality in men with Dupuytren’s disease: a 15 year follow up study. J Clin Epidemiol 2002. 55(1):5–10. doi:10.1016/S0895-4356(01)00413-9.
Gudmundsson KG, Arngrimsson R, Sigfusson N, Bjornsson A, Jonsson T. Epidemiology of Dupuytren’s disease. Clinical, serological, and social assessment. The Reykjavik Study. J Clin Epidemiol 2000. 53(3):291–6. doi:10.1016/S0895-4356(99)00145-6.
Gudmundsson KG, Arngrmsson R, Sigfusson N, Jonsson T. Prevalence of joint complaints amongst individuals with Dupuytren’s disease – from the Reykjavik study. Scand J Rheumatol 1999. 28:300–4. doi:10.1080/03009749950155481.
Guitian AQ. Quelques aspects epidemiologiques de la maladie de Dupuytren. Ann Chir Main 1988. 7:256–62. doi:10.1016/S0753-9053(88)80013-9.
Herzog EG. The etiology of Dupuytren’s contracture. Lancet 1951. 257:1305–6. doi:10.1016/S0140-6736(51)91775-8.
Hindocha S, John S, Stanley JK, Watson SJ, Bayat A. The Heritability of Dupuytren's Disease: Familial Aggregation and Its Clinical Significance. J Hand Surg [Am] 2006. 31(2):204–10. doi:10.1016/j.jhsa.2005.09.018.
Hindocha S, Stanley JK, Watson S, Bayat A. Dupuytren’s diathesis revisited: Evaluation of prognostic indicators for risk of disease recurrence. J Hand Surg [Am] 2006. 31(10):1626–34. doi:10.1016/j.jhsa.2006.09.006.
Hueston JT. The incidence of Dupuytren’s contracture. Med J Aust 1960;2:999–1002.
Kelly SA, Burke FD, Elliot D. Injury to the distal radius as a trigger to the onset of Dupuytren’s disease. J Hand Surg [Br] 1992. 17B:225–9. doi:10.1016/0266-7681(92)90096-K.
Khan AA, Rider OJ, Jayadev CU, Heras-Palou C, Giele H, Goldacre M. The role of manual occupation in the etiology of Dupuytren’s disease in men in England and Wales. J Hand Surg [Br] 20004;29(1):12–4.
Kilian O, Kriegsmann J, Berghauser K, et al. The frozen shoulder. Arthroscopy, histological findings and transmission electron microscopy. Chirurg 2001. 72(11):1303–8. doi:10.1007/s001040170036.
Lane JG, Hankin FM. Dupuytren’s contracture in an adolescent. Am Fam Physician 1988;37(4):133–6.
Laplane D, Carydakis C. Side effects of antiepileptic therapy. Study of 197 cases. Rev Neurol 1985;141(6–7):447–55.
Lennox IAC, Murali SR, Porter R. A study of the repeatability of the diagnosis of Dupuytren’s contracture and its prevalence in the Grampian region. J Hand Surg [Br & Eur] 1993;18B:258–61.
Leon DA, McCambridge J. Liver cirrhosis mortality rates in Britain from 1950 to 2002: an analysis of routine data. Lancet 2006. 367:52–6. doi:10.1016/S0140-6736(06)67924-5.
Liss GM, Stock SR. Can Dupuytren’s contracture be work related?: review of the evidence. Am J Ind Med 1996. 29(5):521–32. doi:10.1002/(SICI)1097-0274(199605)29:5<521::AID-AJIM12>3.0.CO;2-2..
Liu Y, Chen WY. Dupuytren’s disease amongst the Chinese in Taiwan. J Hand Surg [Am] 1991;16(5):779–86.
Logan AJ, Mason G, Dias J, Makwana N. Can rock climbing lead to Dupuytren’s disease? Br J Sports Med 2005. 39(9):639–44. doi:10.1136/bjsm.2004.015792.
Loos B, Puschkin V, Horch RE. 50 years experience with Dupuytren’s contracture in the Erlangen University Hospital—a retrospective analysis of 2919 operated hands from 1956 to 2006. BMC Musculoskelet Disord 2007. 8:60. doi:10.1186/1471-2474-8-60.
Lucas G, Brichet A, Roquelaure Y, Leclerc A, Descatha A. Dupuytren’s disease: Personal factors and occupational exposure. Am J Ind Med 2008. 51:9–15. doi:10.1002/ajim.20542.
Luck JV. Dupuytren’s contracture: a new concept of the pathogenesis correlated with surgical management. J Bone Joint Surg 1959;41A:635–64.
Lyall HA. Dupuytren’s disease in identical twins. J Hand Surg [Br] 1993. 18B:368–70. doi:10.1016/0266-7681(93)90066-O.
Mackenney RP. A population study of Dupuytren’s contracture. Hand 1983. 15(2):155–61. doi:10.1016/S0072-968X(83)80007-2.
Maes J. Dupuytren’s contracture in an Oriental patient. Plast Reconstr Surg 1979. 64:251. doi:10.1097/00006534-197908000-00022.
Makhlouf MV, Cabbabe EB, Shively RE. Dupuytren’s disease in blacks. Ann Plast Surg 1987. 19(4):334–6. doi:10.1097/00000637-198710000-00008.
Mandalia VI, Lowdon IM. Dupuytren’s disease in a child: a case report. J Pediatr Orthop 2003. 12(3):198–9. doi:10.1097/00009957-200305000-00005.
Maravic M, Landais P. Dupuytren’s disease in France – 1831 to 2001 – from description to economic burden. J Hand Surg [Br] 2005. 30B(5):484–7. doi:10.1016/j.jhsb.2005.05.004.
Matthews P. Familial Dupuytren’s contracture with predominantly female expression. Br J Plast Surg 1979. 32(2):120–3. doi:10.1016/0007-1226(79)90010-9.
Maza RK, Goodman RM. A family with Dupuytren’s contracture. J Hered 1968;59(2):155–6.
McFarlane RM. Dupuytren’s disease: relation to work and injury. J Hand Surg [Am] 1991;16:775–9.
McFarlane RM. On the origin and spread of Dupuytren’s disease. J Hand Surg [Am] 2002. 27(3):385–90. doi:10.1053/jhsu.2002.32334.
Mennen U. Dupuytren’s contracture in the Negro. J Hand Surg [Br] 1986. 11(1):61–4. doi:10.1016/0266-7681(86)90015-X.
Mikkelsen OA. Dupuytren’s disease-initial symptoms, age of onset and spontaneous course. Hand 1977. 9(1):11–5. doi:10.1016/S0072-968X(77)80023-5.
Mikkelsen OA. Dupuytren’s disease—the influence of occupation and previous hand injuries. Hand 1978. 10(1):1–8. doi:10.1016/S0072-968X(78)80019-9.
Mikkelsen OA. The prevalence of Dupuytren’s disease in Norway. A study in a representative population sample of the municipality of Haugesund. Acta Chir Scand 1972;138(7):695–700.
Mikkelson OA. The prevalence of Dupuytren’s disease in Norway. A study in a representative population sample in the municipality of Haugesund. Acta Chir Scand 1972;138(7):695–700.
Mitra A, Goldstein RY. Dupuytren’s contracture in the black population: a review. Ann Plast Surg 1994. 32(6):619–22. doi:10.1097/00000637-199406000-00010.
Muguti GI, Appelt B. Dupuytren’s contracture in black Zimbabweans. Cent Afr J Med 1993;39(6):129–32.
Noble J, Arafa M, Royle SG, McGeorge G, Crank S. The association between alcohol, hepatic pathology and Dupuytren’s disease. J Hand Surg [Br].1992;17(1):71–4.
Noble J, Heathcote JG, Cohen H. Diabetes mellitus in the aeitiology of Dupuytren’s disease. J Bone Joint Surg Br 1984;66(3):322–5.
Omari A, Bunker TD. Open surgical release for frozen shoulder: surgical findings and results of the release. J Shoulder Elbow Surg 2001. 10(4):353–7. doi:10.1067/mse.2001.115986.
Pai CH, Tseng CH. Dupuytren’s contracture: report of a Taiwanese case. J Formos Med Assoc 1994;93(8):724–6.
Paller AS, Hebert AA. Knuckle pads in children. Am J Dis Child 1986;140(9):915–7.
Patri B, Gatto A. Raynaud’s syndrome, Dupuytren’s disease, force of prehension and sensitivity of the hand. Study of age-related changes. Ann Chir Main 1986. 5(2):144–7. doi:10.1016/S0753-9053(86)80029-1.
Peto R, Darby s, Deo H, Silcocks P, Whitley E, Doll R. Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case control studies. BMJ 2000. 321:323–9. doi:10.1136/bmj.321.7257.323.
Pierce ERF. —dupuytren’s contracture in three successive generations. Birth Defects Orig Artic Ser 1974;10(5):206–7.
Plasse JS. Dupuytren’s contracture in a black patient. Plast Reconstr Surg 1979. 64:250. doi:10.1097/00006534-197908000-00020.
Rao GS, Luthra PK. Dupuytren’s disease of the foot in children; a report of three cases. Br J Plast Surg 1988. 41(3):313–5. doi:10.1016/0007-1226(88)90117-8.
Ravid M, Dinai Y, Sohar E. Dupuytren’s disease in diabetes mellitus. Acta Diabetol Lat 1977. 14(3–4):170–4. doi:10.1007/BF02581405.
Renard E, Jacques D, Chammas M, et al. Increased prevalence of soft tissue hand lesions in type 1 and type 2 diabetes mellitus: various entities and associated significance. Diabete Metab 1994;20(6):513–21.
Rhomberg M, Rainer C, Gardetto A, Piza-Katzer H. Dupuytren’s disease in children-differential diagnosis. J Pediatr Surg 2002. 37(4):E7. doi:10.1053/jpsu.2002.31646.
Richard-Kadio M, Guedegbe F, Dick R, et al. Dupuytren’s contracture: review of the literature. Case report of a black African. Med Trop 1990;50(3):311–3.
Sanderson PL, Morris MA, Stanley JK, Fahmy NRM. Lipids and Dupuytren’s disease. J Bone Joint Surg Br 1992;74B:923–7.
Schiavon F, Circhetta C, Dani L. The diabetic hand. Rheumatismo 2004;56(3):139–42.
Skoog T. Dupuytren’s contracture with special reference to etiology and improved surgical treatment, its occurance in epileptics, note on knuckle pads. Acta Chir Scand 1948;96(suppl 39):25–175.
Sladicka MS, Benfanti P, Raab M, Becton J. Dupuytren’s contracture in the black population: a case report and review of the literature. J Hand Surg [Am] 1996. 21(5):898–9. doi:10.1016/S0363-5023(96)80211-5.
Smith SP, Devaraj VS, Bunker TD. The association between frozen shoulder and Dupuytren’s disease. J Shoulder Elbow Surg 2001. 10(2):149–51. doi:10.1067/mse.2001.112883.
Srivastava S, Nancarrow JD, Cort DF. Dupuytren’s disease in patients from the Indian sub-continent. Report of ten cases. J Hand Surg [Br] 1989. 14(1):32–4. doi:10.1016/0266-7681(89)90009-0.
Stadner F, Ulreich A, Pfeiffer KP. Dupuytren's contracture as a concomitant disease in diabetes mellitus. Wien Med Wochenschr 1987;137(4):89–92.
Stewart HD, Innes AR, Burke FD. The hand complications of Colles’ fractures. J Hand Surg [Br] 1985. 10(1):103–6. doi:10.1016/S0266-7681(85)80032-2.
Stuhler T, Stankovic P, Ritter G, Schmulder E. Epilepsy and Dupuytren’s contracture—asyntropy of 2 diseases? Handchirurgie 1977;9(4):219–23.
Thomas PR, Clarke D. Vibration white finger and Dupuytren’s contracture: are they related? Occup Med 1992. 42:155–8. doi:10.1093/occmed/42.3.155.
Tomasek JJ, Vaughan MB, Haaksma CJ. Cellular structure and biology of Dupuytren’s disease. Hand Clin 1999;15(1):21–33.
Vathana P, Setpakdi A, Srimongkol T. Dupuytren’s contracture in Thailand. Bull Hosp Jt Dis Orthop Inst 1990;50(1):41–7.
White HA, Alcolado R, Alcolado JC. Examination of the hands: An insight in to the Welsh population. Postgrad Med J 2003. 79:588–9. doi:10.1136/pmj.79.936.588.
Wilbrand S, Ekbom A, Gerdin B. The sex ratio and rate of re-operation and rate of reoperation for Dupuytren’s contracture in men and women. J Hand Surg [Br] 1999. 24(4):456–9. doi:10.1054/jhsb.1999.0154.
Yost J, Winters T, Fett HC. Dupuytren’s contracture. A statistical study. J Hand Surg [Am] 1955;90(4):568–72.
Zaworski RE, Mann RJ. Dupuytren’s contracture in a black patient. Plast Reconstr Surg 1979. 63(1):122–4. doi:10.1097/00006534-197901000-00030.
Zemel NP. Dupuytren’s contracture in women. Hand Clin 1991;7(4):707–11.
Zerajic D, Finsen V. Dupuytren’s disease in Bosnia and Herzegovina. An epidemiological study. BMC Musculoskelet Disord 2004. 5:10. doi:10.1186/1471-2474-5-10.
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Hindocha, S., McGrouther, D.A. & Bayat, A. Epidemiological Evaluation of Dupuytren’s Disease Incidence and Prevalence Rates in Relation to Etiology. HAND 4, 256–269 (2009). https://doi.org/10.1007/s11552-008-9160-9
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DOI: https://doi.org/10.1007/s11552-008-9160-9