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Comparison of the application of B-mode and strain elastography ultrasound in the estimation of lymph node metastasis of papillary thyroid carcinoma based on a radiomics approach

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International Journal of Computer Assisted Radiology and Surgery Aims and scope Submit manuscript

Abstract

Purpose

B-mode ultrasound (B-US) and strain elastography ultrasound (SE-US) images have a potential to distinguish thyroid tumor with different lymph node (LN) status. The purpose of our study is to investigate whether the application of multi-modality images including B-US and SE-US can improve the discriminability of thyroid tumor with LN metastasis based on a radiomics approach.

Methods

Ultrasound (US) images including B-US and SE-US images of 75 papillary thyroid carcinoma (PTC) cases were retrospectively collected. A radiomics approach was developed in this study to estimate LNs status of PTC patients. The approach included image segmentation, quantitative feature extraction, feature selection and classification. Three feature sets were extracted from B-US, SE-US, and multi-modality containing B-US and SE-US. They were used to evaluate the contribution of different modalities. A total of 684 radiomics features have been extracted in our study. We used sparse representation coefficient-based feature selection method with 10-bootstrap to reduce the dimension of feature sets. Support vector machine with leave-one-out cross-validation was used to build the model for estimating LN status.

Results

Using features extracted from both B-US and SE-US, the radiomics-based model produced an area under the receiver operating characteristic curve (AUC) \(=\) 0.90, accuracy (ACC) \(=\) 0.85, sensitivity (SENS) \(=\) 0.77 and specificity (SPEC) \(=\) 0.88, which was better than using features extracted from B-US or SE-US separately.

Conclusions

Multi-modality images provided more information in radiomics study. Combining use of B-US and SE-US could improve the LN metastasis estimation accuracy for PTC patients.

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Acknowledgements

This study was funded by the National Natural Science Foundation of China (61471125)

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Author notes

  1. Tongtong Liu and Xifeng Ge have contributed equally to this work.

Authors and Affiliations

  1. Department of Electronic Engineering, Fudan University, Shanghai, 200433, China

    Tongtong Liu, Jinhua Yu, Yi Guo & Yuanyuan Wang

  2. Key Laboratory of Medical Imaging, Computing and Computer-Assisted Intervention, Shanghai, 200433, China

    Tongtong Liu, Jinhua Yu, Yi Guo & Yuanyuan Wang

  3. Department of Ultrasound, Peking University Third Hospital, Beijing, 100191, China

    Xifeng Ge & Ligang Cui

  4. Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, 20032, China

    Wenping Wang

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  1. Tongtong Liu
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  2. Xifeng Ge
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  3. Jinhua Yu
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  4. Yi Guo
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  5. Yuanyuan Wang
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Correspondence to Jinhua Yu or Ligang Cui.

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Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For retrospective study, formal consent is not required. Informed consent was obtained from all individual participants included in the study. This study has been approved by the ethics committee of the Peking University Third Hospital.

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Liu, T., Ge, X., Yu, J. et al. Comparison of the application of B-mode and strain elastography ultrasound in the estimation of lymph node metastasis of papillary thyroid carcinoma based on a radiomics approach. Int J CARS 13, 1617–1627 (2018). https://doi.org/10.1007/s11548-018-1796-5

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  • DOI: https://doi.org/10.1007/s11548-018-1796-5

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