Abstract
Purpose
To evaluate the clinical value of C-arm CT (CACT)-guided interstitial iodine-125 (125I) brachytherapy on pulmonary tumors.
Materials and methods
30 patients with 40 solid pulmonary tumors were enrolled to undergo CACT-guided interstitial 125I brachytherapy between November 2011 and November 2014. The needle path was planned on a CACT virtual navigation and real-time fluoroscopy system. Technical success, puncture score, procedure time, local control rate (LCR), radiation exposure, complications and survival were investigated.
Results
The technical success of interstitial 125I brachytherapy under CACT guidance was 40/40 (100%). The performance score was 4.7 ± 0.5 with a mean total procedure time of 17.7 ± 5.6 min. LCR in small (≤2.0 cm), intermediate (2.1–4.9 cm) and large (≥5.0 cm) pulmonary tumors was 100, 89.5 and 72.7% at the 4-month follow-up, respectively. The mean effective dose was 10.1 ± 2.8 mSv. Major complications occurred in four patients (13.3%). The mean survival time was 28.4 ± 2.3 months.
Conclusion
CACT can provide virtual navigation and real-time fluoroscopy synchronously for interstitial 125I seed implantation on pulmonary tumors.
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Acknowledgements
This study was funded by the National High Tech Research and Development Program (863 Program) (Grant number: 2015AA020301).
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the Institutional and/or National Research Committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
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Informed consent was obtained from all individual participants included in the study.
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This study was funded by the National High Tech Research and Development Program (863 Program) (Grant Number: 2015AA020301).
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Jiao, D., Ren, K., Li, Z. et al. Clinical role of guidance by C-arm CT for 125I brachytherapy on pulmonary tumors. Radiol med 122, 829–836 (2017). https://doi.org/10.1007/s11547-017-0791-1
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DOI: https://doi.org/10.1007/s11547-017-0791-1