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Flat detector cone-beam CT-guided percutaneous needle biopsy of mediastinal lesions: preliminary experience

  • CHEST RADIOLOGY
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Abstract

Purpose

The purpose of this study was to evaluate the usefulness of flat detector cone-beam CT-guided CBCT percutaneous needle biopsy (PNB) of mediastinal lesions.

Methods

A total of 100 patients with 100 solid mediastinal lesions were retrospectively enrolled to undergo percutaneous needle biopsy (PNB) procedures. The mean diameter of lesions was 4.4 ± 1.8 cm (range 1.8–9.0 cm). The needle path was carefully planned and calculated on the CBCT virtual navigation guidance system, which acquired 3D CT-like cross-sectional images. Diagnostic performance, procedure details, complication rate, and patient radiation exposure were investigated.

Results

The technical success rate of PNB under CBCT virtual navigation system was 100 % (100/100). The sensitivity, specificity, and accuracy of PNB of small nodules under iGuide CBCT virtual navigation guidance were 95.1 % (79/83), 100 % (12/12), and 95.7 % (91/95), respectively. The number of biopsies and CBCT acquisitions were 2.6 ± 1.2 (range 1–6) and 3.0 ± 1.1 (range 2–8), respectively. Complications occurred in five (5.0 %) cases. The mean total procedure time was 11.70 ± 3.44 min (range 6–27 min), resulting in a mean exposure dose of 9.7 ± 4.3 mSv.

Conclusion

Flat detector cone-beam CT-guided PNB is an accurate and safe diagnostic method for mediastinal lesions.

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Authors and Affiliations

  1. Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, People’s Republic of China

    Dechao Jiao, Gang Wu, Yanli Wang & Xinwei Han

  2. Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, People’s Republic of China

    Kai Huang

Authors
  1. Dechao Jiao
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  2. Kai Huang
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  3. Gang Wu
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  4. Yanli Wang
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  5. Xinwei Han
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Corresponding author

Correspondence to Xinwei Han.

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Conflict of interest

The authors declare that they have no conflict of interest.

Research involving human participants

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Funding

This study was funded by the National High-Tech Research and Development Program (863 Program) (Grant Number: 2015AA020301).

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Jiao, D., Huang, K., Wu, G. et al. Flat detector cone-beam CT-guided percutaneous needle biopsy of mediastinal lesions: preliminary experience. Radiol med 121, 769–779 (2016). https://doi.org/10.1007/s11547-016-0660-3

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  • DOI: https://doi.org/10.1007/s11547-016-0660-3

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