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C-arm cone-beam computed tomography needle path overlay for percutaneous biopsy of pulmonary nodules

  • Chest Radiology
  • Published:
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Abstract

Purpose

The aim of this study was to evaluate the feasibility of percutaneous transthoracic needle biopsy of pulmonary nodules under cone-beam computed tomography (CBCT) with “XperGuide” navigation guidance.

Materials and methods

From February 2010 to January 2012, 100 patients (63 men and 37 women; mean age 67.27 years; range 21–88 years) with 100 lung nodules (44 ≤ 3 cm, 56 > 3 cm) underwent CBCT-XperGuide guided percutaneous transthoracic needle biopsies. Technical success, diagnostic accuracy, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and complications were evaluated.

Results

Of 100 nodules (mean size 5.19 cm), 68 were diagnosed as malignant, 27 as benign, and five as indeterminate. Technical success was 95 %. Only 33 of 100 patients underwent surgery: the final pathological diagnosis was concordant with the biopsy diagnosis in 26 cases and discordant in 7 cases (false negatives). Accuracy, sensitivity, specificity, PPV and NPV were 92.6, 90.9, 100, 100 and 72 %, respectively.

Conclusions

CBCT-XperGuide navigation is a new, accurate and safe imaging guidance for percutaneous lung biopsies.

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Conflict of interest

Chiara Floridi, Anna Maria Ierardi, Federico Fontana, Nicola Rotolo, Alessandra Muollo, Ejona Duka, Carlo Pellegrino, Carlo Fugazzola, Gianpaolo Carrafiello declare no conflict of interest.

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Authors and Affiliations

  1. Interventional Radiology, University of Insubria, Varese, Italy

    Chiara Floridi, Federico Fontana, Anna Maria Ierardi & Gianpaolo Carrafiello

  2. Department of Radiology, University of Insubria, Viale Borri 57, 21100, Varese, Italy

    Alessandra Muollo, Ejona Duka & Carlo Pellegrino

  3. Center for Thoracic Surgery, University of Insubria, Viale Borri 57, 21100, Varese, Italy

    Nicola Rotolo

Authors
  1. Chiara Floridi
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  2. Alessandra Muollo
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  3. Federico Fontana
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  4. Nicola Rotolo
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  5. Anna Maria Ierardi
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  6. Ejona Duka
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  7. Carlo Pellegrino
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  8. Gianpaolo Carrafiello
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Corresponding author

Correspondence to Chiara Floridi.

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Floridi, C., Muollo, A., Fontana, F. et al. C-arm cone-beam computed tomography needle path overlay for percutaneous biopsy of pulmonary nodules. Radiol med 119, 820–827 (2014). https://doi.org/10.1007/s11547-014-0406-z

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  • DOI: https://doi.org/10.1007/s11547-014-0406-z

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