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Clinical application of lung ultrasound in patients with acute dyspnoea: differential diagnosis between cardiogenic and pulmonary causes

Applicazione clinica dell’ecografia polmonare nel paziente con dispnea acuta: diagnosi differenziale tra cause cardiogene e polmonari

  • Chest Radiology/Radiologia Toracica
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Abstract

This review discusses the usefulness of bedside lung ultrasound in the diagnostic distinction between the various causes of acute dyspnoea in the emergency department, with special attention to the differential diagnosis of pulmonary oedema and exacerbation of chronic obstructive pulmonary disease (COPD). This is made possible by using mid- to low-end scanners and simple acquisition techniques accessible to both radiologists and clinicians. Major advantages include ready availability at the bedside, the absence of ionising radiation, high reproducibility and cost efficiency. The technique is based on the recognition and analysis of sonographic artefacts rather than direct visualisation of the pulmonary structures. These artefacts are caused by the interaction of water-rich structures and air, called comet tails or B-lines. When such artefacts are widely detected on anterolateral transthoracic lung scans, diffuse alveolar-interstitial syndrome can be diagnosed, which is often a sign of acute pulmonary oedema. This condition rules out exacerbation of COPD as the main cause of acute dyspnoea.

Riassunto

In questo lavoro viene discussa l’utilità dell’ecografia polmonare nella diagnosi delle diverse cause di dispnea acuta in emergenza, in particolare focalizzando l’attenzione sulla diagnosi differenziale tra l’edema polmonare e la riacutizzazione della broncopneumopatia cronica ostruttiva (BPCO). Questo è possibile utilizzando anche ecografi di fascia medio-bassa ed avvalendosi di tecniche di facile acquisizione da parte sia dei radiologi che dei clinici. I maggiori vantaggi dell’ecografia includono la sua pronta disponibilità al letto del malato, l’assenza di radiazioni ionizzanti, la riproducibilità ed i costi ridotti. La tecnica è basata sul riconoscimento e l’analisi di alcuni artefatti invece che sulla visualizzazione diretta delle strutture polmonari. Questi artefatti sono causati dalla presenza di strutture ricche di acqua ed aria, e sono chiamati “code di cometa” o linee B. Quando tali artefatti sono diffusamente visualizzati nelle scansioni trans-toraciche antero-laterali, è possibile diagnosticare la sindrome alveolo-interstiziale diffusa, che è spesso un segno di edema polmonare acuto. Questa condizione esclude la riacutizzazione di BPCO quale causa di dispnea acuta.

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References/Bibliografia

  1. Lichtenstein D, Mezière G, Biderman P et al (1997) The comet tail artifact. An ultrasound sign of alveolar-interstitial syndrome. Am J Respir Crit Care Med 156: 1640–1646

    CAS  PubMed  Google Scholar 

  2. Lien CT, Gillespie ND, Struthers AD, McMurdo ME (2002) Heart failure in frail elderly patients: diagnostic difficulties, co-morbidities, polypharmacy and treatment dilemmas. Eur J Heart Fail 4: 91–98

    Article  PubMed  Google Scholar 

  3. Ray P, Birolleau S, Lefort Y et al (2006) Acute respiratory failure in the elderly: etiology, emergency diagnosis and prognosis. Crit Care 10: R82

    Article  PubMed  Google Scholar 

  4. Holleman DR, Simel DL (1995) Does the clinical examination predict airflow limitation. JAMA 273: 313–319

    Article  PubMed  Google Scholar 

  5. Badgett RG, Lucey CR, Mulrow CD (1997) Can the clinical examination diagnose left-sided heart failure in adults. JAMA 277: 1712–1719

    Article  CAS  PubMed  Google Scholar 

  6. Mulrow CD, Lucey CR, Farnett LE (1993) Discriminating causes of dyspnea through clinical examination. J Gen Intern Med 8: 383–392

    Article  CAS  PubMed  Google Scholar 

  7. Schmitt BP, Kushner MS, Wiener SL (1986) The diagnostic usefulness of the history of the patient with dyspnea. J Gen Intern Med 1: 386–393

    Article  CAS  PubMed  Google Scholar 

  8. Stevenson LW, Perloff JK (1989) The limited reliability of physical signs for estimating hemodynamics in chronic heart failure. JAMA 261: 884–888

    Article  CAS  PubMed  Google Scholar 

  9. Milne EN, Pistolesi M, Miniati M, Giuntini C (1985) The radiologic distinction of cardiogenic and noncardiogenic edema. AJR Am J Roentgenol 144: 879–894

    CAS  PubMed  Google Scholar 

  10. Collins SP, Lindsell CJ, Storrow AB, Abraham WT, ADHERE Scientific Advisory Committee Investigators and Study Group (2006) Prevalence of negative chest radiography results in the emergency department patient with decompensated heart failure. Ann Emerg Med 47: 13–18

    Article  PubMed  Google Scholar 

  11. Davis M, Espiner E, Richards G et al (1994) Plasma brain natriuretic peptide in assessment of acute dyspnoea. Lancet 343: 440–444

    Article  CAS  PubMed  Google Scholar 

  12. Dao Q, Krishnaswamy P, Kazanegra R et al (2001) Utility of B-type natriuretic peptide in the diagnosis of congestive heart failure in an urgent-care setting. J Am Coll Cardiol 37: 379–385

    Article  CAS  PubMed  Google Scholar 

  13. Morrison LK, Harrison A, Krishnaswamy P et al (2002) Utility of a rapid B-natriuretic peptide assay in differentiating congestive heart failure from lung disease in patients presenting with dyspnea. J Am Coll Cardiol 39: 202–209

    Article  CAS  PubMed  Google Scholar 

  14. Collins SP, Ronan-Bentle S, Storrow AB (2003) Diagnostic and prognostic usefulness of natriuretic peptides in emergency department patients with dyspnea. Ann Emerg Med 41: 532–545

    Article  PubMed  Google Scholar 

  15. Davie AP, Love MP, McMurray JJ (1996) Value of ECGs in identifying heart failure due to left ventricular systolic dysfunction. BMJ 313: 300–301

    CAS  PubMed  Google Scholar 

  16. Vasan RS, Benjamin EJ, Levy D (1995) Prevalence, clinical features and prognosis of diastolic heart failure: an epidemiologic perspective. J Am Coll Cardiol 26: 1565–1574

    Article  CAS  PubMed  Google Scholar 

  17. Garcia MJ, Thomas JD, Klein AL (1998) New Doppler echocardiographic applications for the study of diastolic function. J Am Coll Cardiol 32: 865–875

    Article  CAS  PubMed  Google Scholar 

  18. Nagueh S, Middleton K, Koplen H et al (1997) Doppler tissue imaging: a noninvasive technique for evaluation of left ventricular relaxation and estimation of filling pressure. J Am Coll Cardiol 30: 1527–1533

    Article  CAS  PubMed  Google Scholar 

  19. Lichtenstein DA (2007) Ultrasound in the management of thoracic disease. Crit Care Med 35: S250–S261

    Article  PubMed  Google Scholar 

  20. Volpicelli G, Mussa A, Garofalo G et al (2006) Bedside lung ultrasound in the assessment of alveolar-interstitial syndrome. Am J Emerg Med 24: 689–696

    Article  PubMed  Google Scholar 

  21. Copetti R, Soldati G, Copetti P (2008) Chest sonography: a useful tool to differentiate acute cardiogenic pulmonary edema and acute respiratory distress syndrome. Cardiovasc Ultrasound 6: 16

    Article  PubMed  Google Scholar 

  22. Lichtenstein D, Mezière G, Biderman P, Gepner A (1999) The comet-tail artifact: an ultrasound sign ruling out pneumothorax. Intensive Care Med 25: 383–388

    Article  CAS  PubMed  Google Scholar 

  23. Lichtenstein DA, Mezière G, Lascols N et al (2005) Ultrasound diagnosis of occult pneumothorax. Crit Care Med 33: 1231–1238

    Article  PubMed  Google Scholar 

  24. Jambrik Z, Monti S, Coppola V et al (2004) Usefulness of ultrasound lung comets as a nonradiologic sign of extravascular lung water. Am J Card 93: 1265–1270

    Article  PubMed  Google Scholar 

  25. Picano E, Frassi F, Agricola E et al (2006) Ultrasound lung comets: a clinically useful sign of extravascular lung water. J Am Soc Echocardiogr 19: 356–363

    Article  PubMed  Google Scholar 

  26. Reissig A, Kroegel C (2003) Transthoracic sonography of diffuse parenchymal lung disease: the role of comet tail artifacts. J Ultrasound Med 22: 173–180

    PubMed  Google Scholar 

  27. Lichtenstein DA, Mezière GA (2008) Relevance of lung ultrasound in the diagnosis of acute respiratory failure. The BLUE protocol. Chest 134: 117–125

    Article  PubMed  Google Scholar 

  28. Agricola E, Bove T, Oppizzi M et al (2005) Ultrasound comet-tail images: a marker of pulmonary edema: a comparative study with wedge pressure and extravascular lung water. Chest 127: 1690–1695

    Article  PubMed  Google Scholar 

  29. Wohlgenannt S, Gehmacher O, Gehmacher U et al (2001) Sonographic findings in interstitial lung diseases. Ultraschall Med 22: 27–31

    Article  CAS  PubMed  Google Scholar 

  30. Volpicelli G, Caramello V, Cardinale L et al (2008) Detection of sonographic B lines in patients with normal lungs or radiographic alveolar consolidation. Med Sci Monit 14: CR122–CR128

    PubMed  Google Scholar 

  31. Soldati G, Testa A, Silva FR et al (2006) Chest ultrasonography in lung contusion. Chest 130: 533–538

    Article  PubMed  Google Scholar 

  32. Lichtenstein D, Mezière G (1998) A lung ultrasound sign allowing bedside distinction between pulmonary edema and COPD: the comet tail artifact. Intensive Care Med 24: 1331–1334

    Article  CAS  PubMed  Google Scholar 

  33. Volpicelli G, Caramello V, Cardinale L et al (2008) Bedside ultrasound of the lung for the monitoring of acute decompensated heart failure. Am J Em Med 26: 585–591

    Article  Google Scholar 

  34. Fagenholz PJ, Gutman JA, Murray AF et al (2007) Chest ultrasonography for the diagnosis and monitoring of highaltitude pulmonary edema. Chest 131: 1013–1018

    Article  PubMed  Google Scholar 

  35. Gargani L, Frassi F, Soldati G et al (2008) Ultrasound lung comets for the differential diagnosis of acute cardiogenic dyspnoea: a comparison with natriuretic peptides. Eur J Heart Fail 10: 70–77

    Article  CAS  PubMed  Google Scholar 

  36. Volpicelli G, Cardinale L, Garofalo G, Veltri A (2008) Usefulness of lung ultrasound in the bedside distinction between pulmonary edema and exacerbation of COPD. Emerg Radiol 15: 145–151

    Article  PubMed  Google Scholar 

  37. Copetti R, Cattarossi L (2008) Ultrasound diagnosis of pneumonia in children. Radiol Med 113: 190–198

    Article  CAS  PubMed  Google Scholar 

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Cardinale, L., Volpicelli, G., Binello, F. et al. Clinical application of lung ultrasound in patients with acute dyspnoea: differential diagnosis between cardiogenic and pulmonary causes. Radiol med 114, 1053–1064 (2009). https://doi.org/10.1007/s11547-009-0451-1

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  • DOI: https://doi.org/10.1007/s11547-009-0451-1

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