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Novel functions of GABA signaling in adult neurogenesis

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  • Published:
Frontiers in Biology

Abstract

Neurotransmitter gamma-aminobutiric acid (GABA) through ionotropic GABAA and metabotropic GABAB receptors plays key roles in modulating the development, plasticity and function of neuronal networks. GABA is inhibitory in mature neurons but excitatory in immature neurons, neuroblasts and neural stem/progenitor cells (NSCs/NPCs). The switch from excitatory to inhibitory occurs following the development of glutamatergic synaptic input and results from the dynamic changes in the expression of Na+/K+/2Cl− co-transporter NKCC1 driving Cl− influx and neuron-specific K+/Cl− co-transporter KCC2 driving Cl− efflux. The developmental transition of KCC2 expression is regulated by Disrupted-in-Schizophrenia 1 (DISC1) and brain-derived neurotrophic factor (BDNF) signaling. The excitatory GABA signaling during early neurogenesis is important to the activity/experience-induced regulation of NSC quiescence, NPC proliferation, neuroblast migration and new-born neuronal maturation/functional integration. The inhibitory GABA signaling allows for the sparse and static functional networking essential for learning/memory development and maintenance.

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Authors and Affiliations

  1. Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA, 19140, USA

    Adalto Pontes, Yonggang Zhang & Wenhui Hu

  2. Universidade do Estado do Pará, Santarém, PA, Brasil

    Adalto Pontes

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  1. Adalto Pontes
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  2. Yonggang Zhang
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  3. Wenhui Hu
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Correspondence to Wenhui Hu.

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Pontes, A., Zhang, Y. & Hu, W. Novel functions of GABA signaling in adult neurogenesis. Front. Biol. 8, 496–507 (2013). https://doi.org/10.1007/s11515-013-1270-2

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  • DOI: https://doi.org/10.1007/s11515-013-1270-2

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