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The perinucleolar compartment associates with malignancy

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Frontiers in Biology

Abstract

The perinucleolar compartment (PNC) is a unique nuclear substructure, forming predominantly in cancer cells both in vitro and in vivo. PNC prevalence (percentage of cells containing at least one PNC) has been found to positively correlate with disease progression in several cancers (breast, ovarian, and colon). While there is a clear association between PNCs and cancer, the molecular function of the PNC remains unclear. Here we summarize the current understanding of the association of PNCs with cancer and its possible functions in cancer cells.

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  1. Department of Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, IL, 60611, USA

    Yiping Wen, Chen Wang & Sui Huang

  2. College of Veterinary Medicine, Sichuan Agricultural University, Yaan, 625014, China

    Yiping Wen

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  1. Yiping Wen
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  2. Chen Wang
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Correspondence to Sui Huang.

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Wen, Y., Wang, C. & Huang, S. The perinucleolar compartment associates with malignancy. Front. Biol. 8, 369–376 (2013). https://doi.org/10.1007/s11515-013-1265-z

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