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Fabrication and Characteristic of Rhamnolipid-chitosan Coated Emulsions for Loading Ergocalciferol

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Abstract

To overcome the intrinsic limitations of ergocalciferol, layer-by-layer oil-in-water emulsions were formulated and applied in the microencapsulation of ergocalciferol. The primary emulsions were prepared using rhamnolipids to stabilize oil droplets, and then the secondary emulsions were formed by electrostatic deposition of cationic chitosan onto anionic rhamnolipids-coated droplets. The effects of pH, ionic strength, and thermal treatment on the stability of emulsions were investigated. Secondary emulsions were more stable than primary emulsions at low pH and high NaCl concentrations. Both emulsions showed excellent physicochemical stability during long-term storage. The droplet size of ​emulsions remained stable, and the ergocalciferol retention in emulsions was still maintained at over 95% after 30 days of storage. These results indicate that the resistance of prepared emulsions to different environmental stresses is enhanced. Moreover, this study gives important information for extending the utilization of rhamnolipids and chitosan in the delivery system for functional ingredients.

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Data Availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Acknowledgements

This work was supported by the Start-up Program of Shanghai Jiao Tong University (No. 19X100040087).

Author information

Author notes

  1. Zhaoxiang Ma

    Present address: Biobased Chemistry and Technology, Wageningen University and Research, Bornse Weilanden 9, 6708 WG, Wageningen, The Netherlands

Authors and Affiliations

  1. Suizhou Eryuefeng Food Co., Ltd., Suizhou, 441300, Hubei Province, China

    Zhaoxiang Ma

  2. School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China

    Cuixia Sun & Yiguo Zhao

  3. Department of Pharmacy, Lishui Municipal Central Hospital, Zhejiang Province, Lishui, 323000, China

    Zhang Chen

Authors
  1. Zhaoxiang Ma
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  2. Cuixia Sun
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  3. Zhang Chen
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  4. Yiguo Zhao
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Contributions

Zhaoxiang Ma: Investigation, Data curation, Methodology, Writing—Original draft; Cuixia Sun: Validation, Data curation; Zhang Chen: Writing—Review & Editing, Visualization, Conceptualization; Yiguo Zhao: Supervision, Conceptualization, Funding acquisition, Writing—Review & Editing.

Corresponding authors

Correspondence to Zhang Chen or Yiguo Zhao.

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Not applicable, because this paper does not contain any studies with human or animal subjects.

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Ma, Z., Sun, C., Chen, Z. et al. Fabrication and Characteristic of Rhamnolipid-chitosan Coated Emulsions for Loading Ergocalciferol. Food Biophysics 18, 228–239 (2023). https://doi.org/10.1007/s11483-022-09768-1

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