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Regulation of Neuronal Ferritin Heavy Chain, A New Player in Opiate-Induced Chemokine Dysfunction

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Abstract

The heavy chain subunit of ferritin (FHC), a ubiquitous protein best known for its iron-sequestering activity as part of the ferritin complex, has recently been described as a novel inhibitor of signaling through the chemokine receptor CXCR4. Levels of FHC as well as its effects on CXCR4 activation increase in cortical neurons exposed to mu-opioid receptor agonists such as morphine, an effect likely specific to neurons. Major actions of CXCR4 signaling in the mature brain include a promotion of neurogenesis, activation of pro-survival signals, and modulation of excitotoxic pathways; thus, FHC up-regulation may contribute to the neuronal dysfunction often associated with opiate drug abuse. This review summarizes our knowledge of neuronal CXCR4 function, its regulation by opiates and the role of FHC in this process, and known mechanisms controlling FHC production. We speculate on the mechanism involved in FHC regulation by opiates and offer FHC as a new target in opioid-induced neuropathology.

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Acknowledgements

The authors thank members of the Meucci Lab for helpful discussion and the NIH for generous support (R01-DA19808 and R01-DA15014 to OM). Anna (Cook) Abt is a fellow of the “Interdisciplinary and Translational Research Training in neuroAIDS” (T32-MH078795); thus, this investigation was supported in part by the National Institutes of Health under Ruth L. Kirschstein National Research Service Award 5T32MH079785. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH.

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The authors declare no conflicts of interest.

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  1. Departments of Pharmacology and Physiology, Drexel University College of Medicine, 245 N. 15th Street, Philadelphia, PA, 19102, USA

    Anna Cook Abt & Olimpia Meucci

  2. Microbiology and Immunology, Drexel University College of Medicine, 245 N. 15th Street, Philadelphia, PA, 19102, USA

    Olimpia Meucci

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  1. Anna Cook Abt
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Correspondence to Olimpia Meucci.

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This work was funded by NIH grants R01-DA19808 and R01-DA15014 to Olimpia Meucci. Anna Abt is a fellow of the “Interdisciplinary and Translational Research Training in neuroAIDS” (T32-MH078795); thus, this investigation was also supported by the National Institutes of Health under the Ruth L. Kirschstein National Research Service Award 5T32MH079785.

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Abt, A.C., Meucci, O. Regulation of Neuronal Ferritin Heavy Chain, A New Player in Opiate-Induced Chemokine Dysfunction. J Neuroimmune Pharmacol 6, 466–476 (2011). https://doi.org/10.1007/s11481-011-9278-3

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