Abstrafct
Perfluorinated compounds (PFCs) have been detected in many environmental matrices, biota, and nonoccupationally exposed populations in China recently. However, little is known about the distribution and levels of various PFCs in the general population living in areas where there is PFC exposure. In the present study, the levels and prevalence of ten target PFCs were determined in 227 serum samples from a population of nonoccupationally exposed individuals in Shenzhen, China. Results indicated that human exposure to PFCs was prevalent in Shenzhen. Perfluorooctanoate (PFOA) was the dominant PFC contaminant in the serum samples, with a median concentration of 6.72 ng/mL, followed by perfluorooctane sulfonate (PFOS) with a median concentration of 2.07 ng/mL. Other PFCs were detected at much lower concentrations, with median concentrations ranging from 0.02 to 0.87 ng/mL. Statistically, no significant (P>0.05) gender differences were observed for any of the PFCs. Significant (P<0.01) positive correlations were found between age and serum concentrations of the target PFCs, except for perfluorobutane sulfonate (R = −0.16, P = 0.01), perfluorohexanoic acid (R = 0.08, P = 0.22), and perfluoroheptanoic acid (R = −0.11, P = 0.10). Based on the one-compartment pharmacokinetic model, the total daily intakes of PFOA and PFOS for the general population in Shenzhen were calculated as 0.63 and 0.20 ng/kg body weight/day, respectively.
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References
Organization for Economic Co-operation and Development. Cooperation on existing chemicals. Hazard assessment of perfluorooctane sulfonate (PFOS) and its salts, ENV/JM/RD17/FINAL, Paris, 2002
Kissa E. Fluorinated Surfactants and Repellents. 2nd ed. Marcel Dekker: New York, 2001
Giesy J P, Kannan K. Global distribution of perfluorooctane sulfonate in wildlife. Environ Sci Technol, 2001, 35: 1339–1342
Martin J W, Whittle D M, Muir D C G, et al. Perfluoroalkyl contaminants in a food web from Lake Ontario. Environ Sci Technol, 2004, 38: 5379–5385
Lau C, Anitole K, Hodes C, et al. Perfluoroalkyl acids: A review of monitoring and toxicological findings. Toxicol Sci, 2007, 99: 366–394
Martin J W, Smithwick M M, Braune B M, et al. Identification of long-chain perfluorinated acids in biota from the Canadian Arctic. Environ Sci Technol, 2004, 38: 373–380
3M Company. Phase-out plan for POSF-based products, U.S. Environmental Protection Agency Public Docket AR-226-0588. U.S. EPA, St.Paul, MN, 2000
United States Environmental Protection Agency. Perfluorooctane sulfonate: proposed significant new use rule. Fed Reg, 2000, 65: 62319–62333
European Union. Directive 2006/122/ECOF of the European Parliament and of the Council of 12 December 2006. Official J Eur Union, L/372/32-34, 2006
Environment Canada. Order Adding Toxic Substances to Schedule 1 to the Canadian Environmental Protection Act, 1999. Can Gaz Part II. 2006, 140: 2147–2153
Stockholm Convention on Persistent Organic Pollutants. Governments unite to step-up reduction on global DDT reliance and add nine new chemicals under international treaty. Geneva: Stockholm Convention Secretariat, 8 May 2009. http://chm.pops.int/Convention/Pressrelease/COP4Geneva8May2009/tabid/542/language/en-US/Default.aspx
So M K, Taniyasu S, Yamashita N, et al. Perfluorinated compounds in coastal waters of Hong Kong, South China, and Korea. Environ Sci Technol, 2004, 38: 4056–4063
Ju X, Jin Y, Sasaki K, et al. Perfluorinated surfactants in surface, subsurface water and microlayer from Daliao coastal waters in China. Environ Sci Technol, 2008, 42: 3538–3542
Bao J, Liu W, Liu L, et al. Perfluorinated compounds in urban river sediments from Guangzhou and Shanghai of China. Chemosphere, 2010, 80: 123–130
Liu W, Jin Y, Quan X, et al. Perfluorosulfonates and perfluorocar boxylates in snow and rain in Dalian, China. Environ Int, 2009, 35: 737–742
Li X, Yeung L W Y, Taniyasu S, et al. Perfluorooctane sulfonate and related fluorochemicals in the Amur Tiger (Panthera tigris altaica) from China. Environ Sci Technol, 2008, 42: 7078–7083
Yeung L W Y, So M K, Jiang G, et al. Perfluorooctanesulfonate and related fluorochemicals in human blood samples from China. Environ Sci Technol, 2006, 40: 715–720
Jin Y, Saito N, Harada K, et al. Historical trends in human serum levels of perfluorooctanoate and perfluorooctane sulfonate in Shenyang, China. Tohoku J Exp Med, 2007, 212: 63–70
Fromme H, Schlummer M, Moller A, et al. Exposure of an adult population to perfluorinated substances using duplicate diet portions and biomonitoring data. Environ Sci Technol, 2007, 41: 7928–7933
Holzer J, Midasch O, Rauchfuss K, et al. Biomonitoring of perfluorinated compounds in children and adults exposed to perfluorooctanoate-contaminated drinking water. Environ Health Perspect, 2008, 116: 651–657
Emmett E A, Shofer F S, Zhang H, et al. Community exposure to perfluorooctanoate: relationships between serum concentrations and exposure sources. J Occup Environ Med, 2006, 48: 759–770
Shoeib M, Harner T, Wilford B H, et al. Perfluorinated sulfonamides in indoor and outdoor air and indoor dust: Occurrence, partitioning, and human exposure. Environ Sci Technol, 2005, 39: 6599–6606
Fromme H, Tittlemier S A, Völkel W, et al. Perfluorinated compounds-exposure assessment for the general population in western countries. Int J Hyg Environ Health, 2009, 212: 239–270
U.S. Environmental Protection Agency. Provisional Health Advisories for perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), 2009. http://www.epa.gov/waterscience/criteria/drinking/pha-PFOA_PFOS.pdf
Mak Y L, Taniyasu S, Yeung L W Y, et al. Perfluorinated compounds in tap water from China and several other countries. Environ Sci Technol, 2009, 43: 4824–4829
Jin Y, Liu W, Sato I, et al. PFOS and PFOA in environmental and tap water in China. Chemosphere, 2009, 77: 605–611
Post G B, Louis J B, Cooper K R, et al. Occurrence and potential significance of perfluorooctanoic acid (PFOA) detected in New Jersey public drinking water systems. Environ Sci Technol, 2009, 43: 4547–4554
Hansen K J, Clemen L A, Ellefson M E, et al. Compound-specific, quantitative characterization of organic fluorochemicals in biological matrices. Environ Sci Technol, 2001, 35: 766–770
Thompson J, Lorber M, Toms L M L, et al. Use of simple pharmacokinetic modeling to characterize exposure of Australians to perfluorooctanoic acid and perfluorooctane sulfonic acid. Environ Int, 2010, 36: 390–397
Bao J, Liu W, Liu L, et al. Perfluorinated compounds in the environment and the blood of residents living near fluorochemical plants in Fuxin of China. Environ Sci Technol, doi: 10.1021/es102610x
Olsen G W, Burris J M, Ehresman D J, et al. Half-life of serum elimination of perfluorooctanesulfonate, perfluorohexanesulfonate, perfluorooctanoate in retired fluorochemical production workers. Environ Health Perspect, 2007, 115: 1298–1305
Kannan K, Corsolini S, Falandysz J, et al. Perfluorooctanesulfonate and related fluorochemicals in human blood from several countries. Environ Sci Technol, 2004, 38: 4489–4495
Calafat A M, Kuklenyik Z, Reidy J A, et al. Serum concentrations of 11 polyfluoroalkyl compounds in the US population: Data from the National Health and Nutrition Examination Survey (NHANES) 1999–2000. Environ Sci Technol, 2007, 41: 2237–2242
Olsen G W, Church T R, Miller J P, et al. Perfluorooctane sulfonate and other fluorochemicals in the serum of American Red Cross adult blood donors. Environ Health Perspect, 2003, 111: 1892–1901
Corsolini S, Kannan K. Perfluorooctanesulfonate and related fluorochemicals in several organisms including humans from Italy. Organohalogen Compd, 2004, 66: 4079–4085
Harada K, Saito N, Inoue K, et al. The influence of time, sex and geographical factors on levels of perfluorooctane sulfonate in human serum over the last 25 years. J Occup Health, 2004, 46: 141–147
Liu J Y, Li J G, Luan Y, et al. Geographical distribution of perfluorinated compounds in human blood from Liaoning Province, China. Environ Sci Technol, 2009, 43: 4044–4048
Zhang T, Wu Q, Sun H W, et al. Perfluorinated compounds in whole blood samples from infants, children, and adults in China. Environ Sci Technol, 2010, 44: 4341–4347
Toms L M L, Calafat A M, Kato K, et al. Polyfluoroalkyl chemicals in pooled blood serum from infants, children, and adults in Australia. Environ Sci Technol, 2009, 43: 4194–4199
Midasch O, Schettgen T, Angerer J. Pilot study on PFOS and PFOA of the German general population. Int J Hyg Environ Health, 2006, 209: 489–496
Kärrman A, Van Bavel B, Järnberg U, et al. Levels of perfluoroalkylated compounds in whole blood from Sweden. Organohalogen Compd, 2004, 66: 4058–4062
Kärrman A, Mueller J F, Van Bavel B, et al. Levels of 12 perfluorinated chemicals in pooled Australian serum, collected 2002–2003, in relation to age, gender, and region. Environ Sci Technol, 2006, 40: 3742–3748
Calafat A M, Wong L Y, Kuklenyik Z, et al. Polyfluoroalkyl chemicals in the, U.S. population: data from the National Health and Nutrition Examination Survey (NHANES) 2003–2004 and comparisons with NHANES 1999–2000. Environ Health Perspect, 2007, 115: 1596–1602
Fromme H, Midasch O, Twardella D, et al. Occurrence of perfluorinated substances in an adult German population in southern Bavaria. Int Arch Occup Environ Health, 2007, 80: 313–319
Kärrman A, Ericson I, Van Bavel B, et al. Exposure of perfluorinated chemicals through lactation: Levels of matched human milk and serum and a temporal trend, 1996–2004, in Sweden. Environ Health Perspect, 2007, 115: 226–230
Harada K, Inoue K, Morikawa A, et al. Renal clearance of perfluorooctane sulfonate and perfluorooctanoate in humans and their species-specific excretion. Environ Res, 2005, 99: 253–261
Olsen G W, Chang S C, Noker P E, et al. A comparison of the pharmacokinetics of perfluorobutanesulfonate (PFBS) in rats, monkeys, and humans. Toxicology, 2009, 256: 65–74
Inoue K, Okada F, Ito R, et al. Perfluorooctane sulfonate (PFOS) and related perfluorinated compounds in human maternal and cord blood samples: assessment of PFOS exposure in a susceptible population during pregnancy. Environ Health Perspect, 2004, 112: 1204–1207
General Administration of Sport of China. Bulletin of the Second National Fitness Survey of China, 2005
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Li, X., Zhang, J., Liu, W. et al. Serum levels of perfluorinated compounds in the general population in Shenzhen, China. Chin. Sci. Bull. 56, 3092 (2011). https://doi.org/10.1007/s11434-011-4616-7
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DOI: https://doi.org/10.1007/s11434-011-4616-7