Abstract
The present study was designed to investigate possible relationships between the genotypes of hepatitis B virus (HBV) and the HBV-specific cytotoxic T lymphocyte (CTL) responses. HBV genotypes, HBV specific CTL HBV DNA and other markers of HBV infection were determined in 138 patients with chronic hepatitis B. The results showed that the patients infected with genotype C (n=62) had a significantly lower HBV-specific CTL response than those who were infected with HBV genotype B (P<0.01). HBV DNA titer was higher in patients infected with HBV genotype C than in those infected with HBV genotype B (P<0.01). Both alanine aminotransferase (ALT) and total bilirubin (TBIL) were higher in HBV genotype C infected patients than in those infected with genotype B (P<0.01 and <0.05, respectively). These results suggest that compared with CHB patients infected with HBV genotype B, the higher HBV DNA level and more severe liver damages in the patients infected with genotype C of HBV may be associated with genotype C of the virus.
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References
Sugauchi F, Chutaputti A, Orito E, et al. Hepatitis B virus genotypes and clinical manifestation among hepatitis B carriers in Thailand. J Gastroenterol Hepatol, 2002, 17: 671–676 12100612, 10.1046/j.1440-1746.2002.02754.x
Lindh M, Horal P, Dhillon A P, et al. Hepatitis B virus DNA levels, precore mutations, genotypes and histological activity in chronic hepatitis B. J Viral Hepat, 2000, 7: 258–267 10886534, 10.1046/j.1365-2893.2000.00236.x, 1:STN:280:DC%2BD3cvntVCnuw%3D%3D
Kao J H. Hepatitis B virus genotypes and hepatocellular carcinoma in Taiwan. Intervirology, 2003, 46: 400–407 14688459, 10.1159/000074999
Hagiwara S, Kudo M, Minami Y, et al. Clinical significance of the genotype and core promoter/pre-core mutations in hepatitis B virus carriers. Intervirology, 2006, 49: 200–206 16407657, 10.1159/000090789, 1:CAS:528:DC%2BD28XksFKgurc%3D
Zhuang H. Advances in epidemiologic research of hepatitis B (in chinese). Foreign Medical Sciences, Epidemiology and Infectious Diseases, 2004, 31: 133–135
Chinese Society of Infectious Diseases and parasitology and Chinese Society of Hepatology of Chinese Medical Association. The programme of prevention and cure for viral hepatitis. Chin J Hepatol, (in chinese) 2000, 8: 324–329
Deng H, Chong Y T, Han X Y, et al. Changes of antigen-specific cytotoxic T lymp hocytes during acuteflare-ups in chronic hepatitis B patients (in Chinese). Chin J Hepatol, 2006, 14: 721–724 1:CAS:528:DC%2BD2sXhtVyktbnF
Chen Y, Li L J. Advances in research of cell immune responses of specific cytotoxic T lymphocytes in hepatitis B virus infection (in chinese). Foreign Medical Sciences, Epidemiology and Infectious Diseases, 2004, 31: 27–30
Hao Y H, Yang D L. Advances in research of the mechanism of specific cytotoxic T lymphocytes clear intracellular hepatitis B virus (in Chinese). Chin J Cell Mol Immunol, 2005, 21(Suppl): 128–129
Rehemann B. Intrahepatic T cells in hepatitis B viral control versus liver cell injury. J Exp Med, 2000, 191: 1263–1268 10.1084/jem.191.8.1263
Bertoletti A, Ferrari C. Kinetics of the immune response during HBV and HCV infection. Hepatology, 2003, 38: 4–13 12829979, 10.1053/jhep.2003.50310, 1:CAS:528:DC%2BD3sXlvFajurw%3D
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Gu, X., Yang, X., Wang, D. et al. Comparison and significance of specific and non-specific cellular immunity in patients with chronic hepatitis B caused by infection with genotypes B or C of hepatitis B virus. SCI CHINA SER C 52, 719–723 (2009). https://doi.org/10.1007/s11427-009-0098-0
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DOI: https://doi.org/10.1007/s11427-009-0098-0