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Regulation of mammalian pre-mRNA splicing

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Abstract

In eukaryotes, most protein-coding genes contain introns which are removed by precursor messenger RNA (pre-mRNA) splicing. Alternative splicing is a process by which multiple messenger RNAs (mRNAs) are generated from a single pre-mRNA, resulting in functionally distinct proteins. Recent genome-wide analyses of alternative splicing indicated that in higher eukaryotes alternative splicing is an important mechanism that generates proteomic complexity and regulates gene expression. Mis-regulation of splicing causes a wide range of human diseases. This review describes the current understanding of pre-mRNA splicing and the mechanisms that regulate mammalian pre-mRNA splicing. It also discusses emerging directions in the field of alternative splicing.

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  1. State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China

    JingYi Hui

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Correspondence to JingYi Hui.

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Supported by the Program of “one Hundred Talented people” of the Chinese Academy of Sciences.

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Hui, J. Regulation of mammalian pre-mRNA splicing. SCI CHINA SER C 52, 253–260 (2009). https://doi.org/10.1007/s11427-009-0037-0

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