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Polyprenylated acylphloroglucinols from the fruits of Hypericum henryi

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Abstract

Hyphenrones R–X (1–7), seven new polyprenylated acylphloroglucinols derivatives, were isolated from the fruits of Hypericum henryi, together with eight know analogues. Compounds 1 and 2 were elucidated to possess complex caged skeleton, while compounds 3–6 shared a common 3,9-epoxy moiety deriving from the normal polyprenylated acylphloroglucinols with a bicyclo[3.3.1]nonane-2,4,9-trione core. The new structures were elucidated on the basis of the interpretation of nuclear magnetic resonance (NMR) data, circular dichroism (CD) comparison, and single-crystal X-ray diffraction. In the bioassay, several compounds exhibited inhibitory activities against human tumor cell lines in vitro.

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Authors and Affiliations

  1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China

    Yang Liao, Shu-Ya Yang, Xiao-Nian Li, Xing-Wei Yang & Gang Xu

  2. University of Chinese Academy of Sciences, Beijing, 100049, China

    Yang Liao & Shu-Ya Yang

Authors
  1. Yang Liao
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  2. Shu-Ya Yang
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  3. Xiao-Nian Li
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  4. Xing-Wei Yang
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  5. Gang Xu
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Corresponding author

Correspondence to Gang Xu.

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The authors contributed equally to this work.

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Liao, Y., Yang, SY., Li, XN. et al. Polyprenylated acylphloroglucinols from the fruits of Hypericum henryi . Sci. China Chem. 59, 1216–1223 (2016). https://doi.org/10.1007/s11426-016-0052-4

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  • DOI: https://doi.org/10.1007/s11426-016-0052-4

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