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Catalyst-free tandem Michael addition-cyclization reactions in aqueous media for the synthesis of benzimidazo[1,2-a]pyrimidinone derivatives

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Abstract

The catalyst-free reactions of Baylis-Hillman alcohols (1a-i) with 2-aminobenzimidazole (2) in THF-H2O (1:4) were developed for the convenient and greener synthesis of benzimidazo[1,2-a]pyrimidinone derivatives (3a-i). The pesticidal activities of 3a-i were examined to investigate a new biological activity of the imidazo[1,2-a]pyrimidinone-type compounds.

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Authors and Affiliations

  1. Beijing National Laboratory (BNLMS), CAS Key Laboratory for Molecular Recognition and Function, Chinese Academy of Sciences, Beijing, 100190, China

    ChuanLi Ren, Yan Wang, Dong Wang, YongJun Chen & Li Liu

  2. Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China

    ChuanLi Ren, Yan Wang, Dong Wang, YongJun Chen & Li Liu

Authors
  1. ChuanLi Ren
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  2. Yan Wang
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  3. Dong Wang
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  4. YongJun Chen
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  5. Li Liu
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Correspondence to Li Liu.

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Ren, C., Wang, Y., Wang, D. et al. Catalyst-free tandem Michael addition-cyclization reactions in aqueous media for the synthesis of benzimidazo[1,2-a]pyrimidinone derivatives. Sci. China Chem. 53, 1492–1496 (2010). https://doi.org/10.1007/s11426-010-4033-9

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  • DOI: https://doi.org/10.1007/s11426-010-4033-9

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