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Synthesis of Fe3O4@SiO2@polymer nanoparticles for controlled drug release

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Abstract

Novel multifunctional nanoparticles containing a magnetic Fe3O4@SiO2 sphere and a biocompatible block copolymer poly(ethylene glycol)-b-poly(aspartate) (PEG-b-PAsp) were prepared. The silica coated on the superparamagnetic core was able to achieve a magnetic dispersivity, as well as to protect Fe3O4 against oxidation and acid corrosion. The PAsp block was grafted to the surface of Fe3O4@SiO2 nanoparticles by amido bonds, and the PEG block formed the outermost shell. The anticancer agent doxorubicin (DOX) was loaded into the hybrid nanoparticles via an electrostatic interaction between DOX and PAsp. The release rate of DOX could be adjusted by the pH value.

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Authors and Affiliations

  1. Key Laboratory of Functional Polymer Materials, Ministry of Education; Institute of Polymer Chemistry, Nankai University, Tianjin, 300071, China

    ChengLin Wu, Huan He, HongJun Gao, Gan Liu, RuJiang Ma, YingLi An & LinQi Shi

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  1. ChengLin Wu
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  2. Huan He
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  3. HongJun Gao
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  4. Gan Liu
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  5. RuJiang Ma
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  6. YingLi An
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  7. LinQi Shi
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Correspondence to LinQi Shi.

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Wu, C., He, H., Gao, H. et al. Synthesis of Fe3O4@SiO2@polymer nanoparticles for controlled drug release. Sci. China Chem. 53, 514–518 (2010). https://doi.org/10.1007/s11426-010-0084-1

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  • DOI: https://doi.org/10.1007/s11426-010-0084-1

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