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New potent accelerator of neurite outgrowth from Lawsonia inermis flower under non-fasting condition

  • Original Paper
  • Biologically Active Natural Products from Microorganisms and Plants
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Abstract

The methanolic extract of Lawsonia inermis L. (henna) showed accelerative effects on nerve growth factor-induced neurite outgrowth in PC12 cells under non-fasting conditions. To elucidate the active constituents responsible for the neuronal differentiation, we conducted a search of the constituents and examined their accelerative effects on neurite outgrowth in PC12 cells. We isolated a new acetophenone glycoside, inermioside A, which exerted a significant accelerative effect on neurite outgrowth. We also confirmed the activities of nine known compounds, including quercetin and lalioside. In addition, we found that quercetin, one of the active constituents, increased Vav3 mRNA expression.

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Authors and Affiliations

  1. Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan

    Yoshimi Oda, Souichi Nakashima, Seikou Nakamura, Mamiko Yano, Masanori Akiyama, Kayo Imai, Tomohito Kimura, Akiko Nakata, Miyuki Tani & Hisashi Matsuda

  2. N. T. H Co., Ltd., 1-8-11 4F Sky-ebisu Bldg., Ebisu, Shibuya-ku, Tokyo, 150-0013, Japan

    Yoshimi Oda & Souichi Nakashima

Authors
  1. Yoshimi Oda
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  2. Souichi Nakashima
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  3. Seikou Nakamura
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  4. Mamiko Yano
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  5. Masanori Akiyama
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  6. Kayo Imai
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  7. Tomohito Kimura
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  8. Akiko Nakata
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  9. Miyuki Tani
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  10. Hisashi Matsuda
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Correspondence to Souichi Nakashima.

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Oda, Y., Nakashima, S., Nakamura, S. et al. New potent accelerator of neurite outgrowth from Lawsonia inermis flower under non-fasting condition. J Nat Med 70, 384–390 (2016). https://doi.org/10.1007/s11418-016-0974-4

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  • DOI: https://doi.org/10.1007/s11418-016-0974-4

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