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Anti-hyperlipidemic constituents from the bark of Shorea roxburghii

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Abstract

The methanol extract from the bark of Shorea roxburghii (Dipterocarpaceae, “Phayom” in Thai) was found to suppress plasma triglyceride elevation in olive oil-treated mice, and also to inhibit pancreatic lipase activity (IC50 = 31.6 μg/ml). From the extract, two new 3-acetyl-4-phenyl-3,4-dihydroisocoumarins, phayomphenols A1 (1) and A2 (2) were isolated, together with 22 known compounds. The structures of 1 and 2 were elucidated on the basis of chemical and spectroscopic evidence, including X-ray crystallographic analysis. Among the isolates, several oligostilbenoids, including (−)-hopeaphenol (3) and (+)-isohopeaphenol (4), showed inhibitory effects on plasma triglyceride elevation at a dose of 200 mg/kg p.o. and pancreatic lipase inhibitory activity (IC50 = 32.9 and 26.5 μM, respectively).

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Acknowledgments

This work was supported by High-tech Research Center Project for Private Universities: matching fund subsidy from MEXT (The Ministry of Education, Culture, Sports, Science and Technology), 2007-2011 and also supported by a Grant-in Aid for Scientific Research by JSPS (Japan Society for the Promotion of Science).

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Authors and Affiliations

  1. Pharmaceutical Research and Technology Institute, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka, 577-8502, Japan

    Toshio Morikawa, Saowanee Chaipech, Kiyofumi Ninomiya, Masayuki Yoshikawa, Takao Hayakawa & Osamu Muraoka

  2. Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan

    Hisashi Matsuda, Makoto Hamao, Yohei Umeda, Hiroki Sato, Haruka Tamura & Masayuki Yoshikawa

  3. Faculty of Science and Technology, Rajamangala University of Technology Srivijaya, Thungsong, Nakhonsithammarat, 80110, Thailand

    Yutana Pongpiriyadacha

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  1. Toshio Morikawa
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  2. Saowanee Chaipech
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  3. Hisashi Matsuda
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Correspondence to Osamu Muraoka.

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Morikawa, T., Chaipech, S., Matsuda, H. et al. Anti-hyperlipidemic constituents from the bark of Shorea roxburghii . J Nat Med 66, 516–524 (2012). https://doi.org/10.1007/s11418-011-0619-6

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  • DOI: https://doi.org/10.1007/s11418-011-0619-6

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