Summary
Mcl-1 is one member of the Bcl-2 family that has a very short protein half-life. Since its identification in 1993, a great number of studies have implicated that Mcl-1 plays an important role in various cell survival pathways. However, not until recently did the molecular mechanism by which Mcl-1 antagonizes apoptosis have begun to be elucidated. Mcl-1 is rapidly degraded in response to cell death signals and is immediately re-induced by survival stimuli. These results indicate that Mcl-1 plays an apical role in many cell death and survival regulatory programs.
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Acknowledgements
This work was supported in part by an intramural fund from Academia Sinica, and by grants NHRI-EX93-9119BN, NSC 92-3112-B-001-016 from National Health Research Institutes and the National Science Council of Taiwan to H.-F. Yang-Yen.
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Yang-Yen, HF. Mcl-1: a highly regulated cell death and survival controller. J Biomed Sci 13, 201–204 (2006). https://doi.org/10.1007/s11373-005-9064-4
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DOI: https://doi.org/10.1007/s11373-005-9064-4