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Recent advances in CMV tropism, latency, and diagnosis during aging

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Abstract

Human cytomegalovirus (CMV) is one of the largest viruses known to cause human diseases. Chronic CMV infection, as defined by anti-CMV IgG serology, increases with age and is highly prevalent in older adults. It has complex biology with significant immunologic and health consequences. This article aims to summarize research findings presented at the 6th International Workshop on CMV and Immunosenescence that relate to advances in the areas of CMV tropism, latency, CMV manipulation of cell metabolism, and T cell memory inflation, as well as novel diagnostic evaluation and translational research of chronic CMV infection in older adults. Information summarized here represents the current state of knowledge in these important fields. Investigators have also identified a number of areas that deserve further and more in-depth investigation, including building more precise parallels between mouse CMV (mCMV) and human CMV (HCMV) research. It is hoped that this article will also stimulate engaging discussion on strategies and direction to advance the science to the next level.

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Acknowledgments

This work is supported in part by NIH grants R01AI108907 and R21-AG-043874 [to S.X.L]; by 1R01AI116851-01A1 [to J.K.], 1R01AI079059 [to F.G.], and 1R01AG048021 [to J.N-Z., coI F.G.]; and by funding from the Milstein Medical Asian American Partnership (MMAAP) Foundation (www.mmaapf.org) [to S.X.L.].

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  1. Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, JHAAC, Room 1A.38A, 5501 Hopkins Bayview Circle, Baltimore, MD, 21224, USA

    Sean X. Leng, Jeremy Kamil, John G. Purdy, Niels A. Lemmermann, Matthias J. Reddehase & Felicia D. Goodrum

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  1. Sean X. Leng
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  2. Jeremy Kamil
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  3. John G. Purdy
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  4. Niels A. Lemmermann
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  5. Matthias J. Reddehase
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Correspondence to Sean X. Leng.

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Leng, S.X., Kamil, J., Purdy, J.G. et al. Recent advances in CMV tropism, latency, and diagnosis during aging. GeroScience 39, 251–259 (2017). https://doi.org/10.1007/s11357-017-9985-7

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