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Dietary resveratrol prevents Alzheimer’s markers and increases life span in SAMP8

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Abstract

Resveratrol is a polyphenol that is mainly found in grapes and red wine and has been reported to be a caloric restriction (CR) mimetic driven by Sirtuin 1 (SIRT1) activation. Resveratrol increases metabolic rate, insulin sensitivity, mitochondrial biogenesis and physical endurance, and reduces fat accumulation in mice. In addition, resveratrol may be a powerful agent to prevent age-associated neurodegeneration and to improve cognitive deficits in Alzheimer’s disease (AD). Moreover, different findings support the view that longevity in mice could be promoted by CR. In this study, we examined the role of dietary resveratrol in SAMP8 mice, a model of age-related AD. We found that resveratrol supplements increased mean life expectancy and maximal life span in SAMP8 and in their control, the related strain SAMR1. In addition, we examined the resveratrol-mediated neuroprotective effects on several specific hallmarks of AD. We found that long-term dietary resveratrol activates AMPK pathways and pro-survival routes such as SIRT1 in vivo. It also reduces cognitive impairment and has a neuroprotective role, decreasing the amyloid burden and reducing tau hyperphosphorylation.

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Acknowledgments

We thank the Language Advisory Service of the University of Barcelona for revising the manuscript. This study was supported by grants SAF-2009-13093, BFU 2010/22149, SAF-2011-23631, and SAF-2012 from the “Ministerio de Educación y Ciencia,” 2009/SGR00893 from the “Generalitat de Catalunya,” 610RT0405 from the Programa Iberoamericano de Ciencia y Tecnologia para el Desarrollo (CYTED), and the Fundación MAPFRE (Spain).

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Authors and Affiliations

  1. Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Institut de Biomedicina (IBUB), Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Av. Joan XXIII s/n., 08028, Barcelona, Spain

    David Porquet, Sergi Bayod, Alberto Vicente, Anna M. Canudas, Antoni Camins, Mercè Pallàs & Jaume del Valle

  2. Departament de Fisiologia, Facultat de Farmàcia, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Universitat de Barcelona, Av. Joan XXIII s/n., 08028, Barcelona, Spain

    Jordi Vilaplana & Carme Pelegrí

  3. Institut d’Investigacions Biomèdiques de Barcelona (IIBB), CSIC, IDIBAPS, Barcelona, Spain

    Coral Sanfeliu

  4. Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA

    Gemma Casadesús

  5. Grup de Neuroplasticitat i Regeneració, Institut de Neurociències i Departament de Biologia Cel·lular, Fisiologia i Immunologia, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain

    Jaume del Valle

  6. Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Universitat de Barcelona, Avd. Diagonal, 643-08028, Barcelona, Spain

    Mercè Pallàs

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  1. David Porquet
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  2. Gemma Casadesús
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  3. Sergi Bayod
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  4. Alberto Vicente
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  8. Coral Sanfeliu
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  9. Antoni Camins
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  10. Mercè Pallàs
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  11. Jaume del Valle
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Correspondence to Mercè Pallàs.

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Porquet, D., Casadesús, G., Bayod, S. et al. Dietary resveratrol prevents Alzheimer’s markers and increases life span in SAMP8. AGE 35, 1851–1865 (2013). https://doi.org/10.1007/s11357-012-9489-4

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  • DOI: https://doi.org/10.1007/s11357-012-9489-4

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