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Compression leggings modestly affect cardiovascular but not cerebrovascular responses to heat and orthostatic stress in young and older adults

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Abstract

We tested the hypothesis that wearing commercially available compression leggings would attenuate postural reductions in mean arterial blood pressure (MAP) and cerebral perfusion during heat stress, particularly in older adults. Six older (70 years ± 4) and six younger (29 years ± 4) males were heated (esophageal temperature raised 0.5°C) in a water-perfused suit whilst wearing compression or control leggings (>1 week apart, randomized order). Blood flow velocity in the middle cerebral artery (MCAv), blood pressure (photoplethysmography), total peripheral resistance (TPR; ModelFlow) and the partial pressure of end-tidal carbon dioxide were measured continuously before and during 3-min standing in each thermal state. When supine, compression leggings did not change any cardiorespiratory variables in either age group or thermal condition (P > 0.05). Upon standing, wearing compression leggings delayed (~15%; P = 0.044) the maximal drop (nadir) in MAP irrespective of age or thermal condition. During the last minute of standing, wearing compression leggings in normothermia increased TPR (+16%) in older participants but dropped TPR (−8%) in younger participants (P = 0.004 compression × age group). When standing and heated, wearing compression leggings lowered TPR in older and younger participants (~43%; P < 0.01) without changing MAP or MCAv (P > 0.05). In older adults, when standing, compression leggings maintained MAP by elevating TPR. In contrast, under combined heat and orthostatic stress, wearing compression leggings dropped TPR in both older and younger adults, though MAP and MCAv were maintained.

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References

  • Aaslid R, Markwalder TM, Nornes H (1982) Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries. J Neurosurg 57:769–774

    Article  PubMed  CAS  Google Scholar 

  • Agu O, Hamilton G, Baker D (1999) Graduated compression stockings in the prevention of venous thromboembolism. Br J Surg 86:992–1004

    Article  PubMed  CAS  Google Scholar 

  • Ainslie PN, Cotter JD, George KP, Lucas S, Murrell C, Shave R, Thomas KN, Williams MJA, Atkinson G (2008) Elevation in cerebral blood flow velocity with aerobic fitness throughout healthy human ageing. J Physiol 586:4005–4010

    Article  PubMed  CAS  Google Scholar 

  • Bell M, White MJ (2005) Cardiovascular responses to external compression of human calf muscle vary during graded metaboreflex stimulation. Exp Physiol 90:383–391

    Article  PubMed  Google Scholar 

  • Bogert LWJ, van Lieshout JJ (2005) Non-invasive pulsatile arterial pressure and stroke volume changes from the human finger. Exp Physiol 90:437–446

    Article  PubMed  Google Scholar 

  • Brignole M, Alboni P, Benditt DG, Bergfeldt L, Blanc J-J, Thomsen PEB, van Dijk JG, Fitzpatrick A, Hohnloser S, Janousek J, Kapoor W, Kenny RA, Kulakowski P, Masotti G, Moya A, Raviele A, Sutton R, Theodorakis G, Ungar A, Wieling W, The Task Force on Syncope, European Society of Cardiology (2004) Guidelines on management (diagnosis and treatment) of syncope—update 2004. Eur Heart J 25:2054–2072

    Article  PubMed  Google Scholar 

  • Corcondilas A, Koroxenidis GT, Shepherd JT (1964) Effect of a brief contraction of forearm muscles on forearm blood flow. J Appl Physiol 19:142–146

    PubMed  CAS  Google Scholar 

  • Crandall CG, Wilson TE, Marving J, Vogelsang TW, Kjaer A, Hesse B, Secher NH (2008) Effects of passive heating on central blood volume and ventricular dimensions in humans. J Physiol 586:293–301

    Article  PubMed  CAS  Google Scholar 

  • Denq JC, Opfer-Gehrking TL, Giuliani M, Felten J, Convertino VA, Low PA (1997) Efficacy of compression of different capacitance beds in the amelioration of orthostatic hypotension. Clin Auton Res 7:321–326

    Article  PubMed  CAS  Google Scholar 

  • Donaldson GC, Keatinge WR, Saunders RD (2003) Cardiovascular responses to heat stress and their adverse consequences in healthy and vulnerable human populations. Int J Hyperthermia 19:225–235

    Article  PubMed  CAS  Google Scholar 

  • Ferrari AU, Radaelli A, Centola M (2003) Invited review: aging and the cardiovascular system. J Appl Physiol 95:2591–2597

    PubMed  Google Scholar 

  • Fu Q, Witkowski S, Levine BD (2004) Vasoconstrictor reserve and sympathetic neural control of orthostasis. Circulation 110:2931–2937

    Article  PubMed  Google Scholar 

  • Ganzeboom KS, Colman N, Reitsma JB, Shen WK, Wieling W (2003) Prevalence and triggers of syncope in medical students. Am J Cardiol 91:1006–1008

    Article  PubMed  Google Scholar 

  • Hardy JD, DuBois EF (1937) Regulation of heat loss from the human body. Proc Natl Acad Sci USA 23:624–631

    Article  PubMed  CAS  Google Scholar 

  • Harms MP, Wesseling KH, Pott F, Jenstrup M, Van Goudoever J, Secher NH, Van Lieshout JJ (1999) Continuous stroke volume monitoring by modelling flow from non-invasive measurement of arterial pressure in humans under orthostatic stress. Clin Sci (Lond) 97:291–301

    Article  CAS  Google Scholar 

  • Imholz BPM, Wieling W, van Montfrans GA, Wesseling KH (1998) Fifteen years experience with finger arterial pressure monitoring: assessment of the technology. Cardiovasc Res 38:605–616

    Article  PubMed  CAS  Google Scholar 

  • Jellema WT, Wesseling KH, Groeneveld AB, Stoutenbeek CP, Thijs LG, van Lieshout JJ (1999) Continuous cardiac output in septic shock by simulating a model of the aortic input impedance: a comparison with bolus injection thermodilution. Anesthesiology 90:1317–1328

    Article  PubMed  CAS  Google Scholar 

  • Krediet CT, Go-Schön IK, Kim YS, Linzer M, Van Lieshout JJ, Wieling W (2007) Management of initial orthostatic hypotension: lower body muscle tensing attenuates the transient arterial blood pressure decrease upon standing from squatting. Clin Sci 113:401–407

    Article  PubMed  Google Scholar 

  • Lakatta EG (1993a) Cardiovascular regulatory mechanisms in advanced age. Physiol Rev 73:413–467

    PubMed  CAS  Google Scholar 

  • Lakatta EG (1993b) Deficient neuroendocrine regulation of the cardiovascular system with advancing age in healthy humans. Circulation 87:631–636

    PubMed  CAS  Google Scholar 

  • Leonetti P, Audat F, Girard A, Laude D, Lefrère F, Elghozi J (2004) Stroke volume monitored by modeling flow from finger arterial pressure waves mirrors blood volume withdrawn by phlebotomy. Clin Auton Res 14:176–181

    Article  PubMed  Google Scholar 

  • Lucas RAI, Cotter JD, Morrison S, Ainslie PN (2008) The effects of aging and passive heating on cardiorespiratory and cerebrovascular responses to orthostatic stress in humans. Exp Physiol 93:1104–1117

    Article  PubMed  CAS  Google Scholar 

  • Lucas SJE, Tzeng YC, Galvin SD, Thomas KN, Ogoh S, Ainslie PN (2010) Influence of changes in blood pressure on cerebral perfusion and oxygenation. Hypertension 55:698–705

    Article  PubMed  CAS  Google Scholar 

  • Matsukawa K, Kobayashi T, Nakamoto T, Murata J, Komine H, Noso M (2004) Noninvasive evaluation of cardiac output during postural change and exercise in humans: comparison between the modelflow and pulse dye-densitometry. Jpn J Physiol 54:153–160

    Article  PubMed  CAS  Google Scholar 

  • Mayrovitz HN, Larsen PB (1997) Effects of compression bandaging on leg pulsatile blood flow. Clin Physiol 17:105–117

    Article  PubMed  CAS  Google Scholar 

  • Minson CT, Wladkowski SL, Cardell AF, Pawelczyk JA, Kenney WL (1998) Age alters the cardiovascular response to direct passive heating. J Appl Physiol 84:1323–1332

    PubMed  CAS  Google Scholar 

  • Minson CT, Wladkowski SL, Pawelczyk JA, Kenney WL (1999) Age, splanchnic vasoconstriction, and heat stress during tilting. Am J Physiol Regul Integr Comp Physiol 276:R203–R212

    CAS  Google Scholar 

  • Platts SH, Tuxhorn JA, Ribeiro LC, Stenger MB, Lee SMC, Meck JV (2009) Compression garments as countermeasures to orthostatic intolerance. Aviat Space Environ Med 80:437–442

    Article  PubMed  Google Scholar 

  • Remmen JJ, Aengevaeren WRM, Verheugt FWA, van ver Werf T, Luijten HE, Bos A, Jansen RWMM (2002) Finapres arterial pulse wave analysis with modelflow is not a reliable non-invasive method for assessment of cardiac output. Clin Sci 103:143–149

    Article  PubMed  Google Scholar 

  • Romero-Ortuno R, Cogan L, Fan C, Kenny R (2010) Intolerance to initial orthostasis relates to systolic BP changes in elders. Clin Auton Res 20:39–45

    Article  PubMed  Google Scholar 

  • Shi X, Schaller FA, Tierney N, Chanthavong P, Chen S, Raven PB, Smith ML (2008) Physically active lifestyle enhances vagal-cardiac function but not central autonomic neural interaction in elderly humans. Exp Biol Med 233:209–218

    Article  CAS  Google Scholar 

  • Shiraki K, Sagawa S, Yousef MK, Konda N, Miki K (1987) Physiological responses of aged men to head-up tilt during heat exposure. J Appl Physiol 63:576–581

    PubMed  CAS  Google Scholar 

  • Sparrow RA, Hardy JG, Fentem PH (1995) Effect of antiembolism compression hosiery on leg blood-volume. Br J Surg 82:53–59

    Article  PubMed  CAS  Google Scholar 

  • Sugiyama Y, Matsukawa T, Shamsuzzaman AS, Okada H, Watanabe T, Mano T (1996) Delayed and diminished pressor response to muscle sympathetic nerve activity in the elderly. J Appl Physiol 80:869–875

    PubMed  CAS  Google Scholar 

  • Thomas KN, Cotter JD, Galvin SD, Williams MJA, Willie CK, Ainslie PN (2009) Initial orthostatic hypotension is unrelated to orthostatic tolerance in healthy young subjects. J Appl Physiol 107:506–517

    Article  PubMed  Google Scholar 

  • Thomas KN, Burgess KR, Basnyat R, Lucas SJE, Cotter JD, Fan J-L, Peebles KC, Lucas RAI, Ainslie PN (2010) Initial orthostatic hypotension at high altitude. High Alt Med Biol 11:163–167

    Article  PubMed  Google Scholar 

  • Tschakovsky ME, Sheriff DD (2004) Immediate exercise hyperemia: contributions of the muscle pump vs. rapid vasodilation. J Appl Physiol 97:739–747

    Article  PubMed  Google Scholar 

  • Vaddadi G, Lambert E, Corcoran SJ, Esler MD (2007) Postural syncope: mechanisms and management. Med J Aust 187:299–304

    PubMed  Google Scholar 

  • Wieling W, Van Lieshout JJ (1997) Maintenance of postural normotension in humans. In: Low PA (ed) Clinical autonomic disorders—evaluation and management. Lippincott-Raven, Philadelphia, pp 73–82

    Google Scholar 

  • Wieling W, Veerman DP, Dambrink JH, Imholz BP (1992) Disparities in circulatory adjustment to standing between young and elderly subjects explained by pulse contour analysis. Clin Sci 83:149–155

    PubMed  CAS  Google Scholar 

  • Wieling W, Harms MP, ten Harkel AD, van Lieshout JJ, Sprangers RL (1996) Circulatory response evoked by a 3 s bout of dynamic leg exercise in humans. J Physiol 494:601–611

    PubMed  CAS  Google Scholar 

  • Wieling W, Krediet CTP, van dijk N, Linzer M, Tschakovsky ME (2007) Initial orthostatic hypotension: review of a forgotten condition. Clin Sci 112:157–165

    Article  PubMed  Google Scholar 

  • Williamson JW, Mitchell JH, Olesen HL, Raven PB, Secher NH (1994) Reflex increase in blood-pressure induced by leg compression in man. J Physiol 475:351–357

    PubMed  CAS  Google Scholar 

  • Wilson TE, Cui J, Zhang R, Witkowski S, Crandall CG (2002) Skin cooling maintains cerebral blood flow velocity and orthostatic tolerance during tilting in heated humans. J Appl Physiol 93:85–91

    PubMed  Google Scholar 

  • Wilson TE, Tollund C, Yoshiga CC, Dawson EA, Nissen P, Secher NH, Crandall CG (2007) Effects of heat and cold stress on central vascular pressure relationships during orthostasis in humans. J Physiol 585:279–285

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Physiology, University of Otago, Dunedin, New Zealand

    Rebekah Ann Isabel Lucas & Philip N. Ainslie

  2. School of Physical Education, University of Otago, Dunedin, New Zealand

    Rebekah Ann Isabel Lucas, Shawnda A. Morrison & James D. Cotter

  3. Department of Human Kinetics, Faculty of Health and Social Development, University of British Columbia Okanagan, Kelowna, Canada

    Philip N. Ainslie

  4. Institute of Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, USA

    Rebekah Ann Isabel Lucas

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  1. Rebekah Ann Isabel Lucas
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  2. Philip N. Ainslie
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  3. Shawnda A. Morrison
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  4. James D. Cotter
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Correspondence to Rebekah Ann Isabel Lucas.

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Lucas, R.A.I., Ainslie, P.N., Morrison, S.A. et al. Compression leggings modestly affect cardiovascular but not cerebrovascular responses to heat and orthostatic stress in young and older adults. AGE 34, 439–449 (2012). https://doi.org/10.1007/s11357-011-9250-4

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  • DOI: https://doi.org/10.1007/s11357-011-9250-4

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