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Protective effects of Allium hirtifolium Boiss extract on cadmium-induced renal failure in rats

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Abstract

Cadmium (Cd), as a toxic metal, can accumulate in kidneys and induce renal failure. This study was undertaken to evaluate the protective effects of Allium hirtifolium Boiss bulbs against Cd-induced renal failure in rats. Thirty-six rats were divided into 6 groups: group 1, 2, and 3 received vehicle, Cd (100 mg/L/day by drinking water), and AhB extract (200 mg/kg/day; orally), respectively. Groups 4, 5, and 6 were Cd groups which treated AhB extract (50, 100, and 200 mg/kg/day, respectively). After 2 weeks, renal function and oxidative stress markers were determined by using colorimetric methods. Our findings showed that Cd caused a significant increase in creatinine (Cr; p<0.05), uric acid (p<0.01), BUN (p<0.05), serum levels, lipid peroxidation (LPO; p<0.01), and nitric oxide (NO; p<0.01); the depletion of the total antioxidant capacity (TAC; p<0.01) and total thiol molecules (TTM; p<0.001); and structural alterations in the renal tissue. Following AhB extract administration, a remarkable improvement was observed in the functional and oxidative stress markers of renal tissue.

This study suggests that AhB may prevent progression of Cd-induced renal failure via improvement of oxidative/antioxidant balance in renal tissue.

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Acknowledgements

Financial support for this work was provided by vice-chancellor for research and technology, Hamadan University of Medical Sciences, Hamadan, Iran (Grant No. 9412257444).

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Authors and Affiliations

  1. Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran

    Dara Dastan, Sedigheh Karimi, Amir Larki-Harchegani & Amir Nili-Ahmadabadi

  2. Department of Pharmacognosy and Pharmaceutical Biotechnology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran

    Dara Dastan

  3. Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, P.O. Box 8678-3-65178, Hamadan, Iran

    Sedigheh Karimi, Amir Larki-Harchegani & Amir Nili-Ahmadabadi

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  1. Dara Dastan
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  2. Sedigheh Karimi
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  4. Amir Nili-Ahmadabadi
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Correspondence to Amir Nili-Ahmadabadi.

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Dastan, D., Karimi, S., Larki-Harchegani, A. et al. Protective effects of Allium hirtifolium Boiss extract on cadmium-induced renal failure in rats. Environ Sci Pollut Res 26, 18886–18892 (2019). https://doi.org/10.1007/s11356-019-04656-7

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