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Per- and polyfluoroalkyl substances in human breast milk and current analytical methods

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Abstract

Per- and polyfluoroalkyl substances (PFASs) have since become a major health concern as they have been reportedly found in human tissues, blood and breast milk. The main aim of the study was to review the current data on PFASs in human breast milk, including the challenges of analysis as well as the possible modes of transfer from maternal blood. In this paper, previously published data on the concentrations of PFASs in human breast milk from around the world were reviewed and summarised. Eligible studies with reference lists published before 1 June 2017 were included by searching several databases (including Scopus, ScienceOpen and SciFinder). From this search, studies with the number of participants in each study ranging from 2 to 1237 were identified. The review indicated that based on the structural profiles and concentration levels, there was variation in the geographical distribution of these compounds in breast milk. Although there are no recorded investigations on the modes of transfer from maternal blood to breast milk, literature suggests that the PFASs tend to be transferred through binding to various proteins. The review also examined the different sample preparation and analytical methods employed to measure the concentrations of PFASs in human breast milk. This showed that solid phase extraction was the most common extraction method. After extraction, liquid chromatography coupled with tandem mass spectrometry was the most common analysis method. Since several of these methods were initially dedicated to monitoring PFASs in food and water, they demonstrate some limitations with regard to specificity and sensitivity to human fluids. Additionally, there are currently no published records of certified reference materials and/or proficiency scheme devoted to standardising PFAS concentrations in breast milk.

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References

  • Agency for Toxic Substances and Disease Registry (ATSDR) (2015) Draft Toxicological Profile of Perfluoroalkyls, U.S. Department of Health and Human Services, Public Health Service

  • Alexander BH, Olsen GW, Burris JM, Mandel JH, Mandel JS (2003) Mortality of employees of a perfluorooctanesulphonyl fluoride manufacturing facility. Occup Environ Med 60:722–729

    CAS  Google Scholar 

  • Andersen ME, Butenhoff JL, Chang SH, Farrar DG, Kennedy GL Jr, Lau C, Olsen GW, Seed J, Wallace KB (2008) Perfluoroalkyl acids and related chemistries--toxicokinetics and modes of action. Toxicol Sci 102(1):3–14

    CAS  Google Scholar 

  • Apelberg B, Goldman L, Calafat A (2007) Determinants of fetal exposure to polyfluoroalkyl compounds in Baltimore, Maryland. Environ Sci Tech 41(11):3891–3897

    CAS  Google Scholar 

  • Barbarossa A, Masetti R, Gazzotti T, Zama D, Astolfi A, Veyrand B, Pession A, Pagliuca G (2013) Perfluoroalkyl substances in human milk: a first survey in Italy. Environ Int 51:27–30

    CAS  Google Scholar 

  • Beare-Rogers J, Dieffenbacher A, Holm JV (2001) Lexicon of lipid nutrition (IUPAC technical report). Pure Appl Chem 73(4):685–744

    CAS  Google Scholar 

  • Beesoon S, Webster GM, Shoeib M, Harner T, Benskin JP, Martin JW (2011) Isomer profiles of perfluorochemicals in matched maternal, cord, and house dust samples: manufacturing sources and transplacental transfer. Environ Health Perspect 119(11):1659–1664

    CAS  Google Scholar 

  • Bernsmann T, Fürst P (2008) Determination of perfluorinated compounds in human milk. Organohalogen Compd 70:718–721

    CAS  Google Scholar 

  • Bhhatarai B, Gramatica P (2010) Prediction of aqueous solubility, vapor pressure and critical micelle concentration for aquatic partitioning of perfluorinated chemicals. Environ Sci Tech 45:8120–8128

    Google Scholar 

  • Biegel L, Hurrt M, Frame S, O’Connor J, Cook J (2001) Mechanisms of extrahepatic tumor induction by peroxisome proliferators in male CD rats. Toxicol Sci 60:44–55

    CAS  Google Scholar 

  • Black RF (1996) Transmission of HIV-1 in the breast-feeding process. J Am Diet Assoc 96:267–274

    CAS  Google Scholar 

  • Brink A, Lutz U, Volkel W, Lutz WK (2006) Simultaneous determination of O6-methyl-20-deoxyguanosine, 8-oxo-7,8-dihydro-20-deoxyguanosine, and 1,N6-etheno-20-deoxyadenosine in DNA using on-line sample preparation by HPLC column switching coupled to ESI-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci 830:255–261

    CAS  Google Scholar 

  • Buck RC, Franklin J, Berger U, Conder JM, Cousins IT, de Voogt P, Jensen AA, Kannan K, Mabury SA, van Leeuwen SPJ (2011) Perfluoroalkyl and polyfluoroalkyl substances in the environment: terminology, classification, and origins. Integr Environ Assess Manag 7(4):513–541

    CAS  Google Scholar 

  • Butenhoff JL, Olsen GW, Pfahles-Hutchens A (2006) The applicability of biomonitoring data for perfluorooctanesulfonate to the environmental public health continuum. Environ Health Perspect 114(11):1776–1782

    CAS  Google Scholar 

  • Calafat AM, Needham LL, Kuklenyik Z, Reidy JA, Tully JS, Aguilar-Villalobos M et al (2006) Perfluorinated chemicals in selected residents of the American continent. Chemosphere 63:490–496

    CAS  Google Scholar 

  • Casey KA (2005) Chlorpyrifos in human breast milk? dissertation, University of Tennessee

  • ChemicalBook (2012) Product Chemical Properties Available at: ChemicalBook https://www.chemicalbook.com/ProductList_En.aspx?kwd=perfluorooctanoic%20acid

  • Ding G, Peijnenburg WJGM (2013) Physicochemical properties and aquatic toxicity of poly- and perfluorinated compound. Crit Rev Environ Sci Technol 43(6):598–678

    CAS  Google Scholar 

  • Dufková V, Čabala R, Maradová D, Štícha M (2009) A fast derivatization procedure for gas chromatographic analysis of perfluorinated organic acids. J Chromatogr A 1216(49):8659–8664

    Google Scholar 

  • Dufková V, Čabala R, Ševčík V (2012) Determination of C 5–C 12 perfluoroalkyl carboxylic acids in riverwater samples in the Czech Republic by GC–MS after SPE preconcentration. Chemosphere 87(5):463–469

    Google Scholar 

  • ECHA – European Chemicals Agency (2015). Opinion of the Committee for Risk Assessment on an Annex XV dossier proposing restrictions of the manufacture, placing on the market or use of a substance within the EU. Screening assessment perfluorooctanoic acid , its salts, and its precursors. ECHA/RAC/RES-O-0000006229-70-02/F. https://echa.europa.eu/documents/10162/3d13de3a-de0d-49ae-bfbd-749aea884966

  • Enke CG (2007) A predictive model for matrix and analyte effects in electrospray ionization of singly-charged ionic analytes. Anal Chem 69:4885–4893

    Google Scholar 

  • EPA (Environmental Protection Agency) (2012). Perfluorooctanoic Acid (PFOA) and Fluorinated Telomers. Available: http://www.epa.gov/oppt/pfoa/ (Accessed 19 September 2017)

  • Ericson I, Marti-Cid R, Nadal M, Van Bavel B, Lindstrom G, Domingo JL (2008) Human exposure to perfluorinated chemicals through the diet: intake of perfluorinated compounds in foods from the Catalan (Spain) market. J Agric Food Chem 56:1787–1794

    CAS  Google Scholar 

  • Fang X, Zhang L, Feng Y, Zhao Y, Dai J (2008) Immunotoxic effects of perfluorononanoic acid on BALB/c mice. Toxicol Sci 105(2):312–321

    CAS  Google Scholar 

  • Fromme H, Tittlemier SA, Völkel W, Wilhelm M, Twardella D (2010) Perfluorinated comounds-exposure assessment for the general population in western countries. Int J Hyg Environ Health 212:239–270

    Google Scholar 

  • Fujii S, Polprasert C, Tanaka S, Lien NPH, Qiu Y (2007) New POPs in the water environment: distribution, bioaccumulation and treatment of perfluorinated compounds – a review paper. J Water Supply Res Technol 56(5):313–326

    CAS  Google Scholar 

  • Fujii Y, Yan J, Harada KH, Hitomi T, Yang H, Wang P, Koizumi A (2012) Levels and profiles of long-chain perfluorinated carboxylic acids in human breast milk and infant formulas in East Asia. Chemosphere 86(3):315–321

    CAS  Google Scholar 

  • Furdui V, Stock N, Ellis DA, Butt CM, Whittle M, Crozier PW, Reiner EJ, Muir DCG, Mabury S (2007) Spatial distribution of perfluoroalkyl contaminants in lake trout from the Great Lakes. Environ Sci Tech 41:1554–1559

    CAS  Google Scholar 

  • German Federal Environmental Agency (2009) Do without per- and polyfluorinated chemicals and prevent their discharge into the environment

  • Giesy JP, Naile JE, Khim JS, Jones PD, Newsted JL (2010) Aquatic toxicology of Perfluorinated chemicals. In: Whitacre DM (ed) Reviews of environmental contamination and toxicology, vol 202. Springer Science and Business Media, Berlin, pp 1–52

    Google Scholar 

  • Gu C, Jiang G, Szilasie R, Hassan S, Zhang A, Sanders M (2010) Sensitive and accurate quantitation of perfluorinated compounds in human breast milk using selected reaction monitoring assays by LC/ MS/ MS. Thermo fisher scientific. San Jose, CA

  • Guerranti C, Perra G, Corsolini S, Focardi SE (2013) Pilot study on levels of perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) in selected foodstuffs and human milk from Italy. Food Chem 140:197–203

    CAS  Google Scholar 

  • Guzmán MM, Clementini C, Pérez-Cárceles MD, Rejón SJ, Cascone A, Martellini T, Guerranti C, Cincinelli A (2016) Perfluorinated carboxylic acids in human breast milk from Spain and estimation of infant's daily intake. Sci Total Environ 544:595–600

    Google Scholar 

  • Haddow JE, Palomaski GE, Allan WC, Williams JR, Knight GJ, Gagnon J, O’Heir CE, Mitchell ML, Hermos RJ, Waisbren SE (1999) Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N Engl J Med 341:549–555

    CAS  Google Scholar 

  • Hamm MP, Cherry NM, Chan E, Martin JW, Burstyn I (2010) Maternal exposure to perfluorinated acids and fetal growth. J Expo Sci Environ Epidemiol 20:589–597

    CAS  Google Scholar 

  • Han X, Snow TA, Kemper RA, Jepson GW (2003) Binding of perfluorooctanoic acid to rat and human plasma proteins. Chem Res Toxicol 16:775–781

    CAS  Google Scholar 

  • Hanssen L, Rollin H, Øyvind Odland J, Moeb MK, Sandangerab TM (2010) Perfluorinated compounds in maternal serum and cord blood from selected areas of South Africa: results of a pilot study. J Environ Monit 12:1355–1361

    CAS  Google Scholar 

  • Harada K, Saito N, Sasaki K, Inoue K, Koizumi A (2003) Perfluorooctane sulfonate contamination of drinking water in the Tama River, Japan: estimated effects on resident serum levels. Bull Environ Contam Toxicol 71:31–36

    CAS  Google Scholar 

  • Haug LS, Thomsen C, Becher G (2009) A sensitive method for determination of a broad range of perfluorinated compounds in serum suitable for large-scale human biomonitoring. J Chromatogr A 1216(3):385–393

    CAS  Google Scholar 

  • Haug LS, Huber S, Schlabach M, Becher G, Thomsen C (2011) Investigation on per- and polyfluorinated compounds in paired samples of house dust and indoor air from Norwegian homes. Environ Sci Tech 45:7991–7998

    CAS  Google Scholar 

  • Haynes, W.M. (ed.) (2015) CRC Handbook of Chemistry and Physics. 95th Edition. CRC press LLC, Boca Raton, p. 3–436

  • Hinderliter PM, Mylchreest E, Gannon SA, Butenhoff JL, Kennedy GL (2005) Perfluorooctanoate: placental and lactational transport pharmacokinetics in rats. Toxicology 211:139–148

    CAS  Google Scholar 

  • Hoffman K, Vieira V, Webster T, White R (2009) Exposure to polyfluoroalkyl chemicals and attention deficit hyperactivity disorder in U.S. children aged 12-15 years. Abstracts: ISEE 21st annual conference, Dublin, Ireland, Aug 25-29, 2009: poster presentation. Epidemiology 20 (6): S70

  • Hölzer J, Midasch O, Rauchfuss K, Kraft M, Reupert R, Angerer J, Kleeschulte P, Marschall N, Wilhelm M (2008) Biomonitoring of perfluorinated compounds in children and adults exposed to perfluorooctanoate-contaminated drinking water. Environ Health Perspect 116:651–657

    Google Scholar 

  • Houde M, Czub G, Small JM, Backus S, Wang XW, Alaee M, Muir DCG (2008) Fractionation and bioaccumulation of perfluorooctane sulfonate (PFOS) isomers in a Lake Ontario food web. Environ Sci Technol 42:9397–9403

    CAS  Google Scholar 

  • Hu J, Yu J (2010) An LC-MS-MS method for the determination of perfluorinated surfactants in environmental matrices. Chromatographia 72:411–416

    CAS  Google Scholar 

  • Inoue K, Okada F, Ito R (2004) Perfluorooctane sulfonate (PFOS) and related perfluorinated compounds in human maternal and cord blood samples: assessment of PFOS exposure in a susceptible population during pregnancy. Environ Health Perspect 112(11):1204–1207

    CAS  Google Scholar 

  • Jennes R (1979) The composition of milk. Semin Perinatol 3(3):225–239

    Google Scholar 

  • Jones PD, Hu W, de Coen W, Newsted JL, Giesy JP (2003) Binding of perfluorinated fatty acids to serum proteins. Environ Toxicol Chem 22:2639–2649

    CAS  Google Scholar 

  • Jones-Lepp TL, Alvarez DA, Petty JD, Huckins JN (2004) Polar organic chemical integrative sampling (POCIS) and LC-ES/ITMS for assessing selected prescription and illicit drugs treated sewage effluent. Arch Environ Contam Toxicol 47:427–439

    CAS  Google Scholar 

  • Kadar H, Veyrand B, Barbarossa A, Pagliuca G, Legrand A, Bosher C et al (2011) Development of an analytical strategy based on liquid chromatography–high resolution mass spectrometry for measuring perfluorinated compounds in human breast milk: application to the generation of preliminary data regarding perinatal exposure in France. Chemosphere 85:473–480

    CAS  Google Scholar 

  • Kang H, Choi K, Lee HS, Kim DH, Park NY, Kim S, Kho Y (2016) Elevated levels of short carbon-chain PFASAs in breast milk among Korean women: current status and potential challenges. Environ Res 148:351–359

    CAS  Google Scholar 

  • Kannan K, Corsolini S, Fillmann G, Kumar KS, Loganathan BG, Mohd MA, Olivero J, Van Wouwe N, Yang JH, Aldous KM (2004) Perfluorooctanesulfonate and related fluorochemicals in human blood from several countries. Environ Sci Tech 38:4489–4495

    CAS  Google Scholar 

  • Kärrman A, Ericson I, van Bavel B, Darnerud PO, Aune M, Glynn A, Lignall S, Lindström G (2007) Exposure of perfluorinated chemicals through lactation: levels of matched human milk and serum and a temporal trend, 1996-2004, in Sweden. Environ Health Perspect 15(2):225–230

    Google Scholar 

  • Kärrman A, Domingo JL, Llebaria X, Nadal M, Bigas E, van Bavel B, Lindström G (2010) Biomonitoring perfluorinated compounds in Catalonia, Spain: concentrations and trends in human liver and milk samples. Environ Sci Pollut Res Int 17:750–758

    Google Scholar 

  • Kim S-K, Lee KT, Kang CS, Tao L, Kannan K, Kim K-R, Kim C-K, Lee JS, Park PS, Yoo WY, Ha JY, Shin Y-S, Lee J-H (2011) Distribution of perfluorochemicals between sera and milk from the same mothers and implications for prenatal and postnatal exposures. Environ Pollut 159:169–174

    CAS  Google Scholar 

  • Kishi R, Araki A, Minatoya M, Hanaoka T, Miyashita C, Itoh S et al (2017) The Hokkaido birth cohort study on environment and Children’s health: cohort profile— updated 2017. Environ Health Prev Med 22:46

    Google Scholar 

  • Kissa E (1994) Fluorinated surfactants. Marcel Dekker, New York

    Google Scholar 

  • Kissa E (2001) Fluorinated surfactants and repellents (2nd edition revised and expanded). Marcel Dekker, New York

    Google Scholar 

  • Kosswig K (2000) Sulfonic Acids, Aliphatic. Ullmann's encyclopedia of industrial chemistry. 7th ed. (1999-2015). John Wiley & Sons. Online Posting Date: Jun 15, New York

    Google Scholar 

  • Kubwabo C, Kosarac I, Lalonde K (2013) Determination of selected perfluorinated compounds and polyfluoroalkyl phosphate surfactants in human milk. Chemosphere 91:771–777

    CAS  Google Scholar 

  • Kuklenyik Z, Reich JA, Tully JS, Needham LL, Calafat AM (2004) Automated solid – phase extraction and measurement of perfluorinated organic acids and amides in human serum and milk. Environ Sci Technol 38:3698–3704

    CAS  Google Scholar 

  • Lankova D, Lacina O, Pulkrabova J, Hajslova J (2013) The determination of perfluoroalkyl substances, brominated flame retardants and their metabolites in human breast milk and infant formula. Talanta 117:318–325

    CAS  Google Scholar 

  • Larsen BS, Kaiser MA (2007) Challenges in perfluorocarboxylic acid measurements. Anal Chem 79:3966–3973

    CAS  Google Scholar 

  • Lau C, Thibodeux J, Hanson R (2006) Effects of perfluorooctanoic acid exposure during pregnancy in the mouse. Toxicol Sci 90(2):510–518

    CAS  Google Scholar 

  • Lau C, Anitole K, Hodes C, Lai D, Pfhales-Hutchens A, Seed J (2007) Perfluoroalkyl acids: a review of monitoring and toxicological findings. Toxicol Sci 99:366–394

    CAS  Google Scholar 

  • Liu JY, Li JG, Zhou PP, Zhao YF, Wu YN (2008) A modified method for determination of perfluoroalkycarboxylic acids and perfluoroalkyl sulfonic acids in human milk by ultra-performance liquid chromatography and tandem mass spectrometry. Organohalogen Compd 70:2332–2335 Accessible at http://www.dioxin20xx.org (Accessed 05 October 2017)

    CAS  Google Scholar 

  • Liu J, Li J, Zhao Y, Wang Y, Zhang Y, Lei Z, Wu Y (2010) The occurrence of perfluorinated alkyl compounds in human milk from different regions of China. Environ Int 36:433–438

    CAS  Google Scholar 

  • Liu J, Li J, Liu Y, Chan HM, Zhao Y, Cai Z, Wu Y (2011) Comparison on gestation and lactation exposure of perfluorinated compounds for newborns. Environ Int 37:1206–1212

    CAS  Google Scholar 

  • Lorca M, Farré M, Picó Y, Teijón ML, Alvarez JC, Barceló D (2010) Infant exposure of perfluorinated compounds: levels in breast milk and commercial baby food. Environ Int 36:584–592

    Google Scholar 

  • Lorenzo M, Farré M, Blasco C, Onghena M, Picó Y, Barceló D (2016) Perfluoroalkyl substances in breast milk, infant formula and baby food from Valencian community (Spain). Environ Nanotechnol Monit Manage 6:108–115

    Google Scholar 

  • Loveless SE, Finlay C, Everds NE, Frame SR, Gillies PJ, O’Connor JC et al (2006) Comparative responses of rats and mice exposed to linear/branched, linear, or branched ammonium perfluorooctanoate (APFO). Toxicology 220(2–3):203–217

    CAS  Google Scholar 

  • Mabury S (2005) Chemical personality of fluorinated organics. Presentation at FLUOROS 2005: International symposium on fluorinated alkyl organics in the environment. Toronto, Canada, available online: http://www.chem.utoronto.ca/symposium/fluoros/pdfs/SAMFluorosTalk1.pdf

  • MacManus-Spencer LA, Tse ML, Herbert PC, Bischel HB, Luthy RG (2010) Binding of perfluorocarboxylates to serum albumin: a comparison of analytical methods. Anal Chem 82(3):974–981

    CAS  Google Scholar 

  • Martin JW, Mabury SA, Solomon KR, Muir DC (2003) Dietary accumulation of perfluorinated acids in juvenile rainbow trout (Oncorhynchus mykiss). Environ Toxicol Chem 22:189–195

    CAS  Google Scholar 

  • Martin JW, Kannan K, Berger U, Pim de Voogt P, Field J, Franklin J, Giesy JP et al (2004) Analytical challenges hamper perfluoroalkyl research. Environ Sci Tech 38:248A–255A

    CAS  Google Scholar 

  • McManaman JL (2014) Lipid transport in the lactating mammary gland. J Mammary Gland Biol Neoplasia 19(1):35–42

    Google Scholar 

  • Mondal D, Hernandez Weldon R, Armstrong BG, Gibson LJ, Lopez-Espinosa MJ, Shin HM, Fletcher T (2014) Breast feeding: a potential excretion route for mothers and implications for infant exposure to perfloroalkyl acids. Environ Health Perspect 122(2):187–192

    Google Scholar 

  • Mosch C, Kiranoglu M, Fromme H, Volkel W (2010) Simultaneous quantitation of perfluoroalkyl acids in human serum and breast milk using on-line sample preparation by HPLC column switching coupled to ESI-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci 878:2652–2658

    CAS  Google Scholar 

  • Nakata A, Saito M, Iwasaki Y, Ito R, Kishi R, Nakazawa H (2009) Migration from quantitative and maternal blood in milk perfluoro compound. Bunseki Kagaku 58(8):653–659

    CAS  Google Scholar 

  • Nelson JW, Hatch EE, Webster TF (2010) Exposure to polyfluoroalkyl chemicals and cholesterol, body weight, and insulin resistance in the general U.S population. Environ Health Perspect 118(2):197–202

    CAS  Google Scholar 

  • Nutrition Information Centre of the University of Stellenbosch (NICUS) (2006) Feeding babies: Birth to 6 months. http://www.sun.ac.za/nicus/. (Accessed 14 March 2017)

  • Ode A, Källén K, Gustafsson P, Rylander L, Jönsson BAG, Olofsson P, Ivarsson SA, Lindh CH, Rignell-Hydbom A (2014) Fetal Exposure to Perfluorinated Compounds and Attention Deficit Hyperactivity Disorder in Childhood. PLoS One 9(4):e95891. https://doi.org/10.1371/journal.pone.0095891

    Article  CAS  Google Scholar 

  • Ohmori K, Kudo N, Katayama K, Kawashima Y (2003) Comparison of the toxicokinetics between perfluorocarboxylic acids with different carbon chain length. Toxicology 184:135–140

    CAS  Google Scholar 

  • Okada E, Sasaki S, Kashino I, Matsuura H, Miyashita C, Kobayashi S et al (2014) Prenatal exposure to perfluoroalkyl acids and allergic diseases in early childhood. Environ Int 65:127–134

    CAS  Google Scholar 

  • Okáľová Z (2014) Determination of perfluorinated organic acids in soil by gas chromatography. Dissertation, University of Prague

  • Olsen GW, Zobel LR (2007) Assessment of lipid, hepatic, and thyroid parameters with serum perfluorooctanoate (PFOA) concentrations in fluorochemical production workers. Int Arch Occup Environ Health 81:231–246

    CAS  Google Scholar 

  • Olsen GW, Church TR, Miller JP, Burris JM, Hansen KJ, Lundberg JK et al (2003) Perfluorooctanesulfonate and other fluorochemicals in the serum of American Red Cross blood donors. Environ Health Perspect 111:1892–1901

    CAS  Google Scholar 

  • Olsen GW, Burris JM, Ehresman DJ, Froehlich JW, Seacat AM, Butenhoff JL (2007) Half-life of serum elimination of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers. Environ Health Perspect 115:1298–1305

    CAS  Google Scholar 

  • Olsen GW, Mair DC, Church TR, Ellefson ME, Reagen WK, Boyd TM et al (2008) Decline in perflorooctanesulfonate and other polyfluoroalkyl chemicals in American Red Cross adult blood donors, 2000–2006. Environ Sci Tech 42(13):4989–4995

    CAS  Google Scholar 

  • Orata F, Quinete N, Wilken RD (2009) Long chain perfluorinated alkyl acids derivatisation and identification in biota and abiota matrices using gas chromatography. Bull Environ Contam Toxicol 83:630–635

    CAS  Google Scholar 

  • Organisation for Economic Co-operation and Development (OECD) (2005) Results of survey on production and use of PFOS, PFAS and PFOA, related substances and products/mixtures containing these substances. ENV/JM/MONO (2005)1. OECD Environment, Health and Safety Publications. Series on Risk Management No. 19

  • Peters T Jr (1985) Serum albumin. Adv Protein Chem 37:161–245

    CAS  Google Scholar 

  • Reagen WK, Ellefson ME, Kannan K, Giesy JP (2008) Comparison of extraction and quantification methods of perfluorinated compounds in human plasma, serum, and whole blood. Anal Chim Acta 628:214–221

    CAS  Google Scholar 

  • Rodriguez CE, Setzer RW, Barton HA (2009) Pharmacokinetic modeling of perfluorooctanoic acid during gestation and lactation in the mouse. Reprod Toxicol 27:373–386

    CAS  Google Scholar 

  • Roosens L, D’Hollander W, Bervoets L, Reynders H, van Campenhout K, Cornelis C, van Den Heuvel R, Koppen G, Covaci A (2010) Brominated flame retardants and perfluorinated chemicals, two groups of persistent contaminants in Belgian human blood and milk. Environ Pollut 158:2546–2552

    CAS  Google Scholar 

  • Savu P (2000) Fluorine-containing polymers, perfluoroalkanesulfonic acids. Kirk-Othmer encyclopedia of chemical technology. (1999-2016). John Wiley & Sons. Online Posting Date: Dec 4, New York

    Google Scholar 

  • Scheringer M, Trudel D, Horowitz L, Wormuth M, Cousins IT, Hungenbühler K (2007) Konsumentenexposition gegenüber PFOS und PFOA. J Environ Chem Ecotoxicol 14:32–36

    Google Scholar 

  • Schiessel D, Krepich S (2017) Analysis of Perflorinated compounds (PFASs) in aqueous matrices, evaluating various online SPE sorbents by LC-MS/MS. The NELAC Institute poster presentation: http://apps.nelac-institute.org/nemc/2017/docs/pdf/Mon%20&%20Thu-Poster-Other-32.05-chiessel.pdf

  • Shoeib M, Harner T, Vlahos P (2006) Perfluorinated chemicals in the Arctic atmosphere. Environ Sci Tech 40:7577–7583

    CAS  Google Scholar 

  • Slotkin TA, MacKillop EA, Meln RL, Thayer KA, Seidler FJ (2008) Developmental Neurotoxicity of Perfluorinated Chemicals Modeled in Vitro. Environ Health Perspect 116(6):716–722

    CAS  Google Scholar 

  • So MK, Yamashita N, Taniyasu S, Jiang Q, Giesy JP, Chen K et al (2006) Health risks in infants associated with exposure to perfluorinated compounds in human breast milk from Zhoushan, China. Environ Sci Tech 40:2924–2929

    CAS  Google Scholar 

  • Stahl T, Heyn J, Thiele H, Hüther J, Failing K, Georgii S, Brunn H (2009) Carryover of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) from soil to plants. Arch Environ Contam Toxicol 57:289–298

    CAS  Google Scholar 

  • Stahl T, Mattern D, Brunn H (2011) Toxicology of perfluorinated compounds. Environ Sci Euro 23:38. https://doi.org/10.1186/2190-4715-23-38

    Article  CAS  Google Scholar 

  • Steenland K, Jin C, MacNeil J, Lally C, Ducatman A, Vieira V, Fletcher T (2009) Predictors of PFOA levels in a community surrounding a chemical plant. Environ Health Perspect 117:103–108

    Google Scholar 

  • Suchenwirth, R. H. R., Jurling, H., Huppmann, R., Bucking, M. (2006) Perfluorierte Alkyl-Substanzen (PFAS) in der Muttermilch. Bericht des NLGA. Online: /http://www.nlga.niedersachsen.deS (Accessed 14 March 2017)

  • Sun TF, Xiang L, Chen L, Xiao T, Mo CH, Li YW, Cai QY, Hu GC, He DC (2017) Research progresses of determination of perfluorinated compounds in environmental water and solid samples. Chin J Anal Chem 45(4):601–610

    CAS  Google Scholar 

  • Sündstrom M, Ehresman DJ, Bignert A, Butenhoff JL, Olsen GW, Chang SC et al (2011) A temporal trend study (1972–2008) of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in pooled human milk samples from Stockholm, Sweden. Environ Int 37:178–183

    Google Scholar 

  • Taniyasu S, Kannan K, So MK, Gulkowska A, Sinclair E, Okazawa T, Yamashita N (2005) A method for the analysis of fluorotelomer alcohols, fluorotelomer acids, and short- and long-chain perfluorinated acids in water and biota. J Chromatogr A 1093:89–97

    CAS  Google Scholar 

  • Tao L, Kannan K, Wong CM, Arcaro AF, Butenhoff JL (2008a) Perfluorinated compounds in human milk from Massachusetts, U.S.A. Environ Sci Tech 42:3096–3101

    CAS  Google Scholar 

  • Tao L, Ma J, Kunisue T, Libelo EL, Tanabe S, Kannan K (2008b) Perfluorinated compounds in human breast milk from several Asian countries, and in infant formula and dairy milk from the United States. Environ Sci Tech 42:8597–8602

    CAS  Google Scholar 

  • Thibodeaux JR, Hanson RG, Rogers JM, Grey BE, Barbee BD, Richards JH, Butenhoff JL, Stevenson LA, Lau C (2003) Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. I: maternal and prenatal evaluations. Toxicol Sci 74:369–381

    CAS  Google Scholar 

  • Thomsen C, Haug LS, Stigum H, Frøshaug M, Broadwell SL, Becher G (2010) Changes in concentrations of perfluorinated compounds, polybrominated diphenyl ethers, and polychlorinated biphenyls in Norwegian breast-milk during twelve months of lactation. Environ Sci Tech 44:9550–9556

    CAS  Google Scholar 

  • Tittlemier SA, Pepper K, Seymour C, Moisey J, Bronson R, Cao XL, Dabeka RW (2007) Dietary exposure of Canadians to perfluorinated carboxylates and perfluorooctane sulfonate via consumption of meat, fish, fast foods, and food items prepared in their packaging. J Agric Food Chem 55:3203–3210

    CAS  Google Scholar 

  • Trojanowicz M, Koc M (2013) Recent developments in methods for analysis of perfluorinated persistent pollutants. Microchim Acta 180:957–971

    CAS  Google Scholar 

  • Trojanowicz M, Musijowski J, Koc M, Donten MA (2011) Determination of total organic fluorine (TOF) in environmental samples using flow-injection and chromatographic methods. Anal Methods 3:1039–1045

    CAS  Google Scholar 

  • van Leeuwen SPJ, de Boer J (2007) Extraction and clean-up strategies for the analysis of poly- and perfluoroalkyl substances in environmental and human matrices. J Chromatogr A 1153:172–185

    Google Scholar 

  • van Leeuwen SPJ, Swart K, van der Veen I, de Boer J (2008) Significant improvements in the analysis of perfluorinated compounds in water and fish: Results from an interlaboratory method evaluation study Institute for Environmental Studies Report 2008

  • Villagrasa M, de Alda ML, Barceló D (2006) Environmental analysis of fluorinated alkyl substances by liquid chromatography-(tandem) mass spectrometry: a review. Anal Bioanal Chem 386:953–972

    CAS  Google Scholar 

  • Villaverde-de-Sáa E, Racamonde I, Quintana JB, Rodil R, Cela R (2012) Ion-pair sorptive extraction of perfluorinated compounds from water with low-cost polymeric materials: polyethersulfone vs polydimethylsiloxane. Anal Chim Acta 740:50–57

    Google Scholar 

  • Völkel W, Genzel-Boroviczény O, Demmelmair H, Gebauer C, Koletzko B, Twardella D et al (2007) Perfluorooctane sulphonate (PFOS) and perfluorooctanoic acid (PFOA) in human breast milk: results of a pilot study. Int J Hyg Environ Health 211:440–446

    Google Scholar 

  • Wang C, Lü Y, Chen H, Tan L, Teng E (2014) Simultaneous analysis of 14 short- and long-chain perfluorinated compounds in water by liquid chromatography-tandem mass spectrometry using solid phase extraction. Chin J Chromatogr 32(9):919–925

    CAS  Google Scholar 

  • Whitworth KW, Haug LS, Baird DD, Becher G, Hoppin JA, Skjaerven R, Thomsen C, Eggesbo M, Travlos G, Wilson R, Longnecker MP (2012) Perfluorinated compounds and subfecundity in pregnant women. Epidemiology 23(2):257–263

    Google Scholar 

  • Wolf CJ, Fenton S, Schmid J, Catalafat AM, Kuklenyik Z, Bryant A, Thibodeaux J, Das KP, White SS, Lau CS, Abbott BD (2007) Developmental toxicity of perfluorooctanoic acid in the CD-1 mouse after cross-foster and restricted gestational exposures. Toxicol Sci 95(2):462–473

    CAS  Google Scholar 

  • Wolf CJ, Zehr RD, Schmid JE, Lau C, Abbott BD (2010) Developmental effects of perfluorononanoic acid in the mouse are dependent on peroxisome proliferator-activated receptor-alpha. PPAR Res. https://doi.org/10.1155/2010/282896

  • Xiao F, Hanson RA, Golovko SA, Golovko MY, Arnold WA (2018) PFOA and PFOS are generated from zwitterionic and cationic precursor compounds during water disinfection with chlorine or ozone. Environ Sci Tech Let 5(6):382–388

    CAS  Google Scholar 

  • Yamashita N, Kannan K, Taniyasu S, Horii Y, Okazawa T, Petrick G, Gamo T (2004) Analysis of perfluorinated acids at parts-per-quadrillion levels in seawater using liquid chromatography-tandem mass spectrometry. Environ Sci Tech 38(21):5522–5528

    CAS  Google Scholar 

  • Yusa V, Ye X, Calafat AM (2012) Methods for the determination of biomarkers of exposure to emerging pollutants in human specimens. Trends Anal Chem 38:129–142

    CAS  Google Scholar 

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Authors and Affiliations

  1. Sefako Makgatho Health Sciences University, Pretoria, South Africa

    Linda R. Macheka-Tendenguwo, Joshua O. Olowoyo & Liziwe L. Mugivhisa

  2. Agricultural Research Council-OVR, Pretoria, South Africa

    Ovokeroye A. Abafe

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  1. Linda R. Macheka-Tendenguwo
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  2. Joshua O. Olowoyo
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  3. Liziwe L. Mugivhisa
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  4. Ovokeroye A. Abafe
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Correspondence to Linda R. Macheka-Tendenguwo.

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Macheka-Tendenguwo, L.R., Olowoyo, J.O., Mugivhisa, L.L. et al. Per- and polyfluoroalkyl substances in human breast milk and current analytical methods. Environ Sci Pollut Res 25, 36064–36086 (2018). https://doi.org/10.1007/s11356-018-3483-z

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