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Impact of oral cadmium intoxication on levels of different essential trace elements and oxidative stress measures in mice: a response to dose

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Abstract

The study evaluated the effect of oral intoxication of cadmium and the possible causes of oxidative stress and its preferential accumulation in different organs as well as sub-sequential effects in mice. Twenty-four Swiss albino male mice were divided into three groups viz., normal control group without cadmium chloride (CdCl2), whereas a daily dose of 0.5 and 1.2 mg of CdCl2 was orally administered for a period of a week to dose group 1 (DG-1) and dose group 2 (DG-2), respectively. A significant increase in the severity of cadmium toxicity was observed in animals as evidenced by aggravation in liver enzymes viz., serum alanine aminotransferase and aspartate transaminase, whereas lower levels of antioxidative stress markers in liver and kidney tissues of treated mice were observed as compared to normal control group. A significant depletion of calcium levels in liver tissues of DG-1 (217.36 ± 1.73 μg/g of wet tissues) and DG-2 (186.41 ± 1.56 μg/g of wet tissues) groups, along with Cd accumulation, was observed. To summarize, the current study would increase our understanding with respect to dose-dependent absorption of Cd and its toxicity led to mortality as well as adverse health effects in the body of mice.

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Acknowledgements

The authors acknowledge the Director, ICAR-National Dairy Research Institute (NDRI) Karnal-132001, (Haryana), India.

Funding

The first author also acknowledges University Grant Commission (UGC) for the financial support in terms of Rajiv Gandhi National Fellowship (RGNF-SRF) and the moral support given by my family during the research work.

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Correspondence to Chand Ram.

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The authors declare that they have no conflicts of interest.

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Responsible editor: Philippe Garrigues

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Kumar, N., Kumari, V., Ram, C. et al. Impact of oral cadmium intoxication on levels of different essential trace elements and oxidative stress measures in mice: a response to dose. Environ Sci Pollut Res 25, 5401–5411 (2018). https://doi.org/10.1007/s11356-017-0868-3

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  • DOI: https://doi.org/10.1007/s11356-017-0868-3

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