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Sleep duration and sarcopenia risk: a systematic review and dose-response meta-analysis

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Abstract

Purpose

Present systematic literature review and dose-response meta-analysis were carried out to evaluate the association between sleep duration and sarcopenia risk.

Methods

Related studies were found by searching ISI Web of science databases, Scopus, and PubMed, up to May, 2019. Data were available from four studies. A total odds ratio of 17551 participants in these studies was pooled for the current study.

Results

Pooled outcomes from random effects model demonstrated that lowest category of sleep duration (under 6 h) versus reference category (6–8 h) was significantly related with increased risk of sarcopenia (OR: 1.71 95% CI, 1.11, 2.64). Pooled OR also indicated that highest category (more than 8 h) of sleep duration versus reference category (6–8 h) was significantly associated with increased risk of sarcopenia (OR: 1.52 95% CI, 1.23, 1.88). Moreover, subgroup analysis by sex showed that women were affected by both short and long sleep while men were only affected by long sleep duration. The nonlinear dose-response meta-analysis revealed a U-shaped association between sleep duration and the risk of sarcopenia, with a nadir at 8 h per day. The linear dose-response meta-analysis illustrated that the risk of sarcopenia did not change significantly nor for a 0.5-h increment neither for 1-h increment in sleep duration per day.

Conclusion

The outcomes from this meta-analysis indicate that the public should be made aware of the negative consequences of long and short sleep for sarcopenia especially among women. Further studies should now be undertaken to establish possible links between risk of sarcopenia and sleep duration.

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Abbreviations

CI:

Confidence interval

GH:

Growth hormone

HPA:

Hypothalamo-pituitary-adrenal

IGF-1:

Insulin-like growth factor-1

OR:

Odds ratio

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Authors and Affiliations

  1. Department of Physiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Ali Pourmotabbed & Atefeh Babaei

  2. Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Ali Pourmotabbed & Habibolah Khazaie

  3. Students’ Scientific Research Center (SSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran

    Ehsan Ghaedi

  4. Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

    Ehsan Ghaedi

  5. Department of Clinical Nutrition, School of Nutrition and Food Science, Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran

    Hamed Mohammadi

  6. Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Cyrus Jalili

  7. The Early Life Research Unit, Academic Division of Child Health, Obstetrics and Gynaecology, and Nottingham Digestive Disease Centre and Biomedical Research Centre, The School of Medicine, University of Nottingham, Nottingham, NG7 2UH, UK

    Michael E. Symonds

  8. Halal Research Center of IRI, Food and Drug Administration of Iran, Tehran, Iran

    Sajjad Moradi

  9. Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

    Sajjad Moradi

  10. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Maryam Miraghajani

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  1. Ali Pourmotabbed
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Pourmotabbed, A., Ghaedi, E., Babaei, A. et al. Sleep duration and sarcopenia risk: a systematic review and dose-response meta-analysis. Sleep Breath 24, 1267–1278 (2020). https://doi.org/10.1007/s11325-019-01965-6

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