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Determination of new prediction formula for nasal continuous positive airway pressure in Turkish patients with obstructive sleep apnea syndrome

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Abstract

Background

Race/ethnicity may play an important role in determining body size, severity of obstructive sleep apnea syndrome (OSAS), and effective continuous positive airway pressure (CPAP) (Peff). Turkey is composed of different ethnic groups. Therefore, the aims of this study were to determine new prediction formula for CPAP (Ppred) in Turkish OSAS patients, validate performance of this formula, and compare with Caucasian and Asian formulas.

Methods

Peff of 250 newly diagnosed moderate-to-severe OSAS patients were calculated by in-laboratory manual titration. Correlation and multiple linear regression analysis were used to model effects of ten anthropometric and polysomnographic variables such as neck circumference (NC) and oxygen desaturation index (ODI) on Peff. New formula was validated in different 130 OSAS patients and compared with previous formulas.

Results

The final prediction formula was \( {\text{Ppred}} = \left( {0.{148} \times {\text{NC}}} \right) + \left( {0.0{38} \times {\text{ODI}}} \right) \). When Peff of control group was assessed, it was observed that mean Peff was 8.39 ± 2.00 cmH2O and Ppred was 8.23 ± 1.22 cmH2O. Ppred was within ±3 cmH2O of Peff in 96.2% patients. Besides, Peff was significantly correlated with new formula, and prediction formulas developed for Caucasian and Asian populations (r = 0.651, p < 0.001, r = 0.648, p < 0.001, and r = 0.622, p < 0.001, respectively).

Conclusions

It is shown that level of CPAP can be successfully predicted from our prediction formula, using NC and ODI and validated in Turkish OSAS patients. New equation correlates with other formulas developed for Caucasian and Asian populations. Our simple formula including ODI, marker of intermittent hypoxia, may be used easily in different populations.

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Conflict of interest

The authors declare that they have no conflicts of interest.

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Authors and Affiliations

  1. Department of Chest Diseases, Sleep Laboratory, Ege University School of Medicine, 35100, Bornova, Izmir, Turkey

    Ozen K. Basoglu & Mehmet Sezai Tasbakan

Authors
  1. Ozen K. Basoglu
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  2. Mehmet Sezai Tasbakan
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Correspondence to Ozen K. Basoglu.

Additional information

The manuscript was presented as an abstract at Sleep and Breathing Conference 2011, Prague.

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Basoglu, O.K., Tasbakan, M.S. Determination of new prediction formula for nasal continuous positive airway pressure in Turkish patients with obstructive sleep apnea syndrome. Sleep Breath 16, 1121–1127 (2012). https://doi.org/10.1007/s11325-011-0612-z

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  • DOI: https://doi.org/10.1007/s11325-011-0612-z

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