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Formula for predicting OSA and the Apnea–Hypopnea Index in Koreans with suspected OSA using clinical, anthropometric, and cephalometric variables

  • Sleep Breathing Physiology and Disorders • Original Article
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Abstract

Purpose

This study developed formulas to predict obstructive sleep apnea (OSA) and the Apnea–Hypopnea Index (AHI) in Korean patients with suspected OSA using clinical, anthropometric, and cephalometric variables.

Methods

We evaluated relevant variables in 285 subjects with suspected OSA. These included demographic characteristics, sleep-related symptoms, medical history, clinical scales, anthropometric measurements including facial surface measurements, and cephalometric measurements. All participants underwent full-night laboratory polysomnography. The prediction formula for the probability of OSA was created by logistic regression analysis and confirmed by the bootstrap resampling technique. The formula for predicting the AHI was developed using multiple linear regression analysis.

Results

The probability of having OSA was as follows: p = 1 / (1 + exponential (exp)−f), where f = −16.508 + 1.445 × loudness of snoring 4 + 0.485 × loudness of snoring 3 + 0.078 × waist circumference + 0.209 × subnasale-to-stomion distance + 0.183 × thickness of the uvula (UTH) supine + 0.041 × age. The AHI prediction formula was as follows: −112.606 + 3.516 × body mass index + 0.683 × mandibular plane–hyoid supine + 10.915 × loudness of snoring 4 + 6.933 × loudness of snoring 3 + 1.297 × UTH supine + 0.272 × age.

Conclusion

This is the first study to establish formulas to predict OSA and the AHI in Koreans with suspected OSA using cephalometric and other variables. These results will contribute to prioritizing the order in which patients with suspected OSA are referred for polysomnography.

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Author notes

  1. Seon Tae Kim and Kee Hyung Park contributed equally to this work.

Authors and Affiliations

  1. Department of Otolaryngology, Gil Medical Center, College of Medicine, Gachon University, Incheon, Republic of Korea

    Seon Tae Kim

  2. Department of Neurology, Gil Medical Center, College of Medicine, Gachon University, Incheon, Republic of Korea

    Kee Hyung Park

  3. Department of Otorhinolaryngology, School of Medicine, Catholic University of Daegu, Daegu, Republic of Korea

    Seung-Heon Shin

  4. Department of Neurology, School of Medicine, Catholic University of Daegu, Daegu, Republic of Korea

    Ji-Eun Kim

  5. Department of Psychiatry, Bucheon St. Mary’s Hospital, College of Medicine, Catholic University of Korea, Bucheon, Republic of Korea

    Chi-Un Pae

  6. Department of Preventive Medicine, College of Medicine, Gachon University, Incheon, Republic of Korea

    Kwang-Pil Ko

  7. Department of Radiology, Gil Medical Center, Gachon University, College of Medicine, Incheon, Republic of Korea

    Hee Young Hwang

  8. Department of Psychiatry, Gil Medical Center, College of Medicine, Gachon University, 1198, Guwol-dong, Namdong-Gu, Incheon, 21565, Republic of Korea

    Seung-Gul Kang

Authors
  1. Seon Tae Kim
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  2. Kee Hyung Park
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Corresponding author

Correspondence to Seung-Gul Kang.

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Funding

The National Research Foundation of Korea (NRF) provided the financial support in the form of Basic Science Research Program funding (NRF-2011-0013991, NRF-2013R1A1A2059105). The sponsor had no role in the design or conduct of this research.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Conflict of interest

The authors declare that they have no competing interests.

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Kim, S.T., Park, K.H., Shin, SH. et al. Formula for predicting OSA and the Apnea–Hypopnea Index in Koreans with suspected OSA using clinical, anthropometric, and cephalometric variables. Sleep Breath 21, 885–892 (2017). https://doi.org/10.1007/s11325-017-1506-5

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  • DOI: https://doi.org/10.1007/s11325-017-1506-5

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