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Fast-Specific Tomography Imaging via Cerenkov Emission

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Abstract

Purpose

Development of more tumor-specific radiopharmaceuticals is not enough; to understand the disease, we must study data modeling. Although fluoro-18-deoxyglucose positron emission tomography can map a multi-peak distribution of trace radioisotopes, optical tomography should also be able to redirect the distribution.

Procedures

Multi-view image acquisition of small animals injected with 2-deoxy-2-[18F]fluoro-d-glucose began with X-ray computed tomography scanning and Cerenkov luminescence imaging. After fusion processing, utilization of the geometric row scaling and L 1/2 regularization operator effectively generates in vivo Cerenkov luminescence tomography images with the SP3 forward model.

Results

The identification is confirmed by the comparison between tumor-specific tomography from Cerenkov emission and the radioactivity measured in vitro.

Conclusion

The proposed technique can quickly localize the mobility of radionuclides and uptake by organs, which provides an imaging methodology in oncology.

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Acknowledgments

This paper is supported by the National Basic Research Program of China (973 Program) under grant no. 2011CB707700; the Knowledge Innovation Project of the Chinese Academy of Sciences under grant no. KGCX2-YW-907; the National Natural Science Foundation of China under grant nos. 81027002, 81071205, and 30970778; the Fellowship for Young International Scientists of the Chinese Academy of Sciences under grant no. 2010Y2GA03; and the Chinese Academy of Sciences Visiting Professorship for Senior International Scientists under grant no. 2010T2G36.

Conflict of Interest Statement

None.

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Authors and Affiliations

  1. Intelligent Medical Research Center, Institute of Automation, Chinese Academy of Sciences, Room 931, Automation Building, No.95 Zhongguancun East Road, Beijing, 100190, China

    Jianghong Zhong, Chenghu Qin, Xin Yang, Zhe Chen, Xiang Yang & Jie Tian

Authors
  1. Jianghong Zhong
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  2. Chenghu Qin
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  3. Xin Yang
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  4. Zhe Chen
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  5. Xiang Yang
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  6. Jie Tian
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Corresponding author

Correspondence to Jie Tian.

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Zhong, J., Qin, C., Yang, X. et al. Fast-Specific Tomography Imaging via Cerenkov Emission. Mol Imaging Biol 14, 286–292 (2012). https://doi.org/10.1007/s11307-011-0510-6

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