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Quantitative Effects of Contrast Enhanced CT Attenuation Correction on PET SUV Measurements

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Abstract

Purpose

The presence of contrast materials on computed tomography (CT) images can cause problems in the attenuation correction of positron emission tomography (PET) images. These are because of errors converting the CT attenuation of contrast to 511-keV attenuation and by the change in tissue enhancement over the duration of the PET emission scan. Newer CT-based attenuation correction (CTAC) algorithms have been developed to reduce these errors.

Methods

To evaluate the effectiveness of the modified CTAC technique, we performed a retrospective analysis on 20 patients, comparing PET images using unenhanced and contrast-enhanced CT scans for attenuation correction. A phantom study was performed to simulate the effects of contrast on radiotracer concentration measurements.

Results

There was a maximum difference in calculated radiotracer concentrations of 5.9% within the retrospective data and 7% within the phantom data.

Conclusion

Using a CTAC algorithm that de-emphasizes high-density areas, contrast-enhanced CT can be used for attenuation mapping without significant errors in quantitation.

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Authors and Affiliations

  1. Department of Radiology, Nuclear Medicine Section, Duke University Medical Center, Durham, NC, 27710, USA

    Tira Bunyaviroch, Timothy G. Turkington, Terence Z. Wong, John W. Wilson & R. Edward Coleman

  2. GE Healthcare Technologies, Milwaukee, WI, USA

    James G. Colsher

Authors
  1. Tira Bunyaviroch
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  2. Timothy G. Turkington
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  3. Terence Z. Wong
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  4. John W. Wilson
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  5. James G. Colsher
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  6. R. Edward Coleman
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Correspondence to Tira Bunyaviroch.

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Bunyaviroch, T., Turkington, T.G., Wong, T.Z. et al. Quantitative Effects of Contrast Enhanced CT Attenuation Correction on PET SUV Measurements. Mol Imaging Biol 10, 107–113 (2008). https://doi.org/10.1007/s11307-007-0126-z

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  • DOI: https://doi.org/10.1007/s11307-007-0126-z

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