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Inhibitory effect of extracts from Brazilian medicinal plants on the adhesion of Candida albicans to buccal epithelial cells

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Abstract

Plants are known to produce a plethora of secondary metabolites which are recognized as a useful source of new drugs or drug leads. Extracts and fractions of Schinus terebinthifolius Raddi (Anacardiaceae), Piper regnellii C.D.C. (Piperaceae), Rumex acetosa L. (Polygonaceae), and Punica granatum L. (Punicaceae) were assessed for their antifungal activity against eight clinical isolates of C. albicans. They were also evaluated for their effect on the adhesion of these C. albicans isolates to buccal epithelial cells (BECs). The ethyl acetate fraction from the leaves of S. terebinthifolius showed promising activity, inhibiting the growth of three C. albicans isolates at 7.8 μg ml−1 and significantly inhibiting their adhesion to BEC at 15 μg ml−1 . In addition, this fraction did not show cytotoxic activity against murine macrophages. The results show the potential of the plant extracts studied as a source of new antifungal compounds. Further studies are necessary for isolation and characterization of the active compounds of these plants.

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Acknowledgements

We would like to thank the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) from Brazil for financial support. The authors also thank EPAGRI from Itajaí, SC, Brazil, for providing and identifying some of the plant species and also thanks to Prof. Dr. Daniel Barcellos Falkenberg of the Department of Botany of UFSC who identified the species.

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Authors and Affiliations

  1. Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil

    Susana Johann, Daniele L. Silva, Cleide V. B. Martins & Maria A. Resende

  2. Laboratório de Química de Produtos Naturais, Centro de Pesquisa René Rachou, Fiocruz, Av. Augusto de Lima, 1715 Barro Preto Cx. Postal 1743, CEP 30190-002, Belo Horizonte, MG, Brazil

    Susana Johann & Carlos L. Zani

  3. Centro de Engenharias e Ciências Exatas, Universidade Estadual do Oeste do Paraná, Toledo, PR, Brazil

    Cleide V. B. Martins

  4. Departamento de Química, Universidade Federal de Santa Catarina, Florianopolis, SC, Brazil

    Moacir G. Pizzolatti

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  1. Susana Johann
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  2. Daniele L. Silva
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  3. Cleide V. B. Martins
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  4. Carlos L. Zani
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  5. Moacir G. Pizzolatti
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  6. Maria A. Resende
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Correspondence to Susana Johann.

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Johann, S., Silva, D.L., Martins, C.V.B. et al. Inhibitory effect of extracts from Brazilian medicinal plants on the adhesion of Candida albicans to buccal epithelial cells. World J Microbiol Biotechnol 24, 2459–2464 (2008). https://doi.org/10.1007/s11274-008-9768-5

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  • DOI: https://doi.org/10.1007/s11274-008-9768-5

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