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Distribution of Latent Herpes Simplex Virus Type-1 and Varicella Zoster Virus DNA in Human Trigeminal Ganglia

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Abstract

Trigeminal ganglia removed at autopsy from immunocompetent individuals without cutaneous signs of herpesvirus infection were fixed, cut into 5-μm sections, and screened at 100-μm intervals (20 adjacent sections) by PCR for latent herpes simplex type 1(HSV-1) and varicella zoster virus (VZV) DNA. Sections that contained >5 neurons with nuclei stained by hematoxylin/eosin revealed HSV-1 DNA in most samples and VZV DNA in approximately 50% of samples. HSV-1 and VZV DNA were distributed throughout each latently infected ganglion.

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Authors and Affiliations

  1. Departments of Neurology, University of Colorado Health Sciences Center, 4200 E. 9th Avenue, Mail Stop B182, Denver, CO , 80262, USA

    Randall J. Cohrs, James J. Laguardia & Donald Gilden

  2. Departments of Microbiology, University of Colorado Health Sciences Center, 4200 E. 9th Avenue, Mail Stop B182, Denver, CO , 80262, USA

    Donald Gilden

  3. Department of Neurology, Southern Illinois University School of Medicine, First Street 701 N, Springfield, IL, 62794-9637, USA

    James J. Laguardia

Authors
  1. Randall J. Cohrs
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  2. James J. Laguardia
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  3. Donald Gilden
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Correspondence to Randall J. Cohrs.

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Cohrs, R.J., Laguardia, J.J. & Gilden, D. Distribution of Latent Herpes Simplex Virus Type-1 and Varicella Zoster Virus DNA in Human Trigeminal Ganglia. Virus Genes 31, 223–227 (2005). https://doi.org/10.1007/s11262-005-1799-5

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  • DOI: https://doi.org/10.1007/s11262-005-1799-5

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