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Aerobic exercise in adults with chronic kidney disease (CKD): a meta-analysis

  • Nephrology - Review
  • Published:
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Abstract

Purpose

Patients with chronic kidney disease (CKD) are frail and have high risk of cardiovascular disease. This study was performed to assess the effects of aerobic exercise training in adults with CKD.

Methods

MEDLINE, EMBASE, CENTRAL, Web of Science were searched up to December 2018 to identify eligible randomized controlled trials (RCTs) that studied aerobic exercise in adults with CKD. Primary outcomes include oxygen consumption at peak exercise (VO2 peak), exercise capacity, blood pressure, heart rate, and health-related quality of life (HRQoL). Statistical analysis was performed using Review Manager 5.2.1 software.

Results

Thirty-one trials, containing 1305 adults with CKD, were included. The most used aerobic exercise program was characterized as moderate intensity (15/31), 3 times/week frequency (22/31), 30 min duration (9/31) and 3 months follow-up (12/31). Significant improvement was observed in cardiorespiratory function (VO2 peak) (P < 0.0001), exercise duration (P < 0.0001), HDL-C (P = 0.03) and pain (P = 0.007), physical role (P = 0.03), general health (P = 0.007) of HRQoL after aerobic exercise in patients with CKD. A marginal difference was observed in HR max (P = 0.07). However, no statistical difference was noticed in exercise capacity, blood pressure, resting heart rate, serum lipid and serum creatinine between aerobic training group and control. No subgroup differences were altered in all outcomes when studies were divided based on intensity of exercise training, the treatment of dialysis or the length of intervention.

Conclusions

Aerobic exercise training could benefit adult CKD patients in increasing cardiorespiratory function, exercise duration, HDL-C level and improve health quality of life.

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Authors and Affiliations

  1. Division of Nephrology, Department of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China

    Gaiqin Pei, Yi Tang & Wei Qin

  2. Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu, China

    Long Ge

  3. West China School of Medicine, Sichuan University, Chengdu, Sichuan, China

    Gaiqin Pei, Li Tan & Jiaxing Tan

Authors
  1. Gaiqin Pei
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  2. Yi Tang
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  3. Li Tan
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  4. Jiaxing Tan
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  5. Long Ge
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  6. Wei Qin
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Correspondence to Wei Qin.

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Pei, G., Tang, Y., Tan, L. et al. Aerobic exercise in adults with chronic kidney disease (CKD): a meta-analysis. Int Urol Nephrol 51, 1787–1795 (2019). https://doi.org/10.1007/s11255-019-02234-x

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  • DOI: https://doi.org/10.1007/s11255-019-02234-x

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