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Impact of home-based aerobic exercise on the physical capacity of overweight patients with chronic kidney disease

  • Nephrology - Original Paper
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Abstract

Background

Home-based exercise has been shown to provide benefits in terms of physical capacity in the general population, but has been scarcely investigated in patients with chronic kidney disease (CKD).

Aims

To evaluate the impact of a home-based aerobic training on the cardiopulmonary and functional capacities of overweight non-dialysis-dependent patients with CKD (NDD-CKD).

Methods

Twenty-nine sedentary patients (55.1 ± 11.6 years, BMI = 31.2 ± 6.1 kg/m2, eGFR = 26.9 ± 17.4 mL/min/1.73 m2) were randomly assigned to a home-based exercise group (n = 14) or to a control group (n = 15) that remained without performing exercise. Aerobic training was performed three times per week for 12 weeks. A cardiopulmonary exercise test, functional capacity and clinical parameters were evaluated.

Results

A significant increase, ranging from 8.3 to 17 %, was observed in the cardiopulmonary capacity parameters, such as maximal ventilation (p = 0.005), VO2peak (p = 0.049), ventilatory threshold (p = 0.040) and respiratory compensation point (p < 0.001), of the exercise group. A simultaneous improvement in the functional capacity tests [6-min walk test (p < 0.001), time up and go test (p < 0.001), arm curl test (p < 0.001), sit and stand test (p < 0.001), 2-min step test (p < 0.001) and back scratch test (p = 0.042)] was also found in patients who were submitted to the exercise. Exercised patients experienced a decrease in systolic and diastolic blood pressure, average 10.6 % (p < 0.001) and 9.2 % (p = 0.007), respectively, and a trend toward improved renal function (p = 0.1). No change in any parameter was found in the control group during the follow-up.

Conclusion

The home-based aerobic exercise program was feasible, safe and effective for the improvement in the cardiopulmonary and functional capacities of overweight NDD-CKD patients.

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Acknowledgments

This study was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo–Fapesp (2009/14786-0), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Oswaldo Ramos Foundation and Centro de Estudos em Psicobiologia e Exercício/Associação de Fundo e Incentivo à Pesquisa.

Conflict of interest

The authors have no conflicts of interest to disclose.

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Authors and Affiliations

  1. Division of Nephrology, Federal University of São Paulo, Rua Pedro de Toledo, 282, São Paulo, SP, 04039-000, Brazil

    Danilo Takashi Aoike, Maria Ayako Kamimura, Adriano Ammirati & Lilian Cuppari

  2. Nutrition Program, Federal University of São Paulo, São Paulo, SP, Brazil

    Flavia Baria, Maria Ayako Kamimura, Marco Túlio de Mello & Lilian Cuppari

  3. Department of Psychobiology, Federal University of São Paulo, São Paulo, SP, Brazil

    Marco Túlio de Mello

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  1. Danilo Takashi Aoike
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  2. Flavia Baria
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  3. Maria Ayako Kamimura
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  5. Marco Túlio de Mello
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  6. Lilian Cuppari
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Correspondence to Lilian Cuppari.

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Aoike, D.T., Baria, F., Kamimura, M.A. et al. Impact of home-based aerobic exercise on the physical capacity of overweight patients with chronic kidney disease. Int Urol Nephrol 47, 359–367 (2015). https://doi.org/10.1007/s11255-014-0894-8

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